Neuromuscular Junction - Physiology
Research News and Information

Saturday, November 21, 2009

Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/ankyrin/microtubule cytoskeleton.

3 Oct 2009 Loss of spectrin or ankyrin in the presynaptic motoneuron disrupts the synaptic microtubule cytoskeleton and leads to disassembly of the neuromuscular junction (NMJ). Here, we demonstrate that NMJ disassembly after loss of alpha-spectrin can be ... Read more...

Motoneuron transplantation rescues the phenotype of SMARD1 (spinal muscular atrophy with respiratory distress type 1).

21 Sep 2009 Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a fatal form of infantile motoneuron disease. There is currently no effective treatment, although motor neuron replacement is a possible therapeutic strategy. We transplanted ... Read more...

PP2A and GSK-3beta act antagonistically to regulate active zone development.

14 Sep 2009 The synapse is composed of an active zone apposed to a postsynaptic cluster of neurotransmitter receptors. Each Drosophila neuromuscular junction comprises hundreds of such individual release sites apposed to clusters of glutamate receptors. Here, ... Read more...

Latest indexed articles for 'Neuromuscular Junction - Physiology'

These are the very latest articles for this heading:

• Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/ankyrin/microtubule cytoskeleton. 3 Oct 2009
• Motoneuron transplantation rescues the phenotype of SMARD1 (spinal muscular atrophy with respiratory distress type 1). 21 Sep 2009
• PP2A and GSK-3beta act antagonistically to regulate active zone development. 14 Sep 2009
• A new ion channel blooms at the synapse. 8 Sep 2009
• The biomechanics of cycling with a transtibial amputation: Recommendations for prosthetic design and direction for future research. 30 Aug 2009
• WNTs tune up the neuromuscular junction. 30 Aug 2009
• MSC p43 required for axonal development in motor neurons. 24 Aug 2009
• Molecular mechanisms determining conserved properties of short-term synaptic depression revealed in NSF and SNAP-25 conditional mutants. 9 Aug 2009
• Development of the neuromuscular system during asexual propagation in an invertebrate chordate. 30 Jul 2009
• Improved denture retention in patients with retracted tongues. 30 Jul 2009
• A critical step for postsynaptic F-actin organization: regulation of Baz/Par-3 localization by aPKC and PTEN. 30 Jul 2009
• Contribution of occlusal activity to synaptogenesis in masticatory muscles. 30 Jul 2009
• AAGBI guidelines on the use of neuromuscular blockade monitoring. 30 Jul 2009
• Postoperative residual curarisation--facts and fictions. 30 Jul 2009
• Identification of an agrin mutation that causes congenital myasthenia and affects synapse function. 21 Jul 2009
• Deal breaker: semaphorin and specificity in the spinal stretch reflex circuit. 14 Jul 2009
• [The role of cholesterol in exo- and endocytosis of the synaptic vesicles at the frog motor nerve terminal] 29 Jun 2009
• Effects of inserting fluorescent proteins into the alpha1S II-III loop: insights into excitation-contraction coupling. 29 Jun 2009
• Cell type-specific requirements for heparan sulfate biosynthesis at the Drosophila neuromuscular junction: effects on synapse function, membrane trafficking, and mitochondrial localization. 29 Jun 2009
• Current concepts in neuromuscular transmission. 29 Jun 2009

See a longer list of these articles.

Technical information about 'Neuromuscular Junction'

Definition: The synapse between a neuron and a muscle.

Descriptor UI: D009469

Alternative terms: Neuromuscular Junction; Junction, Neuromuscular; Junctions, Neuromuscular; Neuromuscular Junctions; Myoneural Junction; Junction, Myoneural; Junctions, Myoneural; Myoneural Junctions; Nerve-Muscle Preparation; Nerve Muscle Preparation; Nerve-Muscle Preparations; Preparation, Nerve-Muscle; Preparations, Nerve-Muscle;

Related Mesh Headings: Neuromuscular Blocking Agents; Neuromuscular Depolarizing Agents; Receptors, Cholinergic;

Allowable Qualifiers: abnormalities; anatomy & histology; blood supply; cytology; drug effects; embryology; enzymology; growth & development; immunology; injuries; metabolism; microbiology; parasitology; pathology; physiology; physiopathology; radiation effects; radiography; radionuclide imaging; secretion; surgery; ultrastructure; ultrasonography; chemistry; virology; genetics;

Tree Number: A08.800.550.550.550; A08.850.550.550; A11.284.149.165.420.780.550.550;

Online Note: use NEUROMUSCULAR JUNCTION to search MYONEURAL JUNCTION 1966-67

History Note: 68; was MYONEURAL JUNCTION 1963-67

Technical Notes: /drug eff: consider also NEUROMUSCULAR BLOCKING AGENTS or NEUROMUSCULAR DEPOLARIZING AGENTS; neuromusc transm = NEUROMUSCULAR JUNCTION /physiol + NEURAL TRANSMISSION; dis = NEUROMUSCULAR JUNCTION DISEASES