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Neuroprotective Agents - Pharmacology
Research News and Information
Definition of 'Neuroprotective Agents'Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. Common names: Neuroprotective Agents; Agents, Neuroprotective; Neuroprotectants; Neuroprotective Drugs; Drugs, Neuroprotective |
Saturday, November 21, 2009
p38SJ, a novel DINGG protein protects neuronal cells from alcohol induced injury and death.
29 Nov 2009 
Ethanol induces neuronal cell injury and death by dysregulating several signaling events that are controlled, in part, by activation of MAPK/ERK1/2 and/or inactivation of its corresponding phosphatase, PP1. Recently, we have purified a novel protein ... Read more...
2 Nov 2009 Caspases play an important role as mediators of cell death in acute and chronic neurological disorders. Although peptide inhibitors of caspases provide neuroprotection, they have to be administered intracerebroventricularly because they cannot cross ... Read more...
Volatile anesthetics attenuate oxidative stress-reduced activity of glutamate transporter type 3.
30 Oct 2009 BACKGROUND: Volatile anesthetics enhance the activity of glutamate transporter Type 3 (also called excitatory amino acid transporter Type 3, EAAT3), the major neuronal EAAT. In addition to glutamate, EAAT3 can also uptake L-cysteine, the ... Read more...
Latest indexed articles for 'Neuroprotective Agents - Pharmacology'
These are the very latest articles for this heading:
- p38SJ, a novel DINGG protein protects neuronal cells from alcohol induced injury and death. 29 Nov 2009
- A nanomedicine transports a peptide caspase-3 inhibitor across the blood-brain barrier and provides neuroprotection. 2 Nov 2009
- Volatile anesthetics attenuate oxidative stress-reduced activity of glutamate transporter type 3. 30 Oct 2009
- Propofol inhibits aquaporin 4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral ischemia/reoxygenation. 30 Oct 2009
- Disruption of the axon initial segment cytoskeleton is a new mechanism for neuronal injury. 19 Oct 2009
- Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. 17 Oct 2009
- mTOR signaling in epileptogenesis: too much of a good thing?
5 Oct 2009 - Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord. 29 Sep 2009
- Differential effects of topiramate on prefrontal glutamatergic transmission when combined with raclopride or clozapine. 29 Sep 2009
- A repertoire of rhythmic bursting produced by hypoglossal motoneurons in physiological and pathological conditions. 10 Sep 2009
- Pharmacologic interventions for stroke: looking beyond the thrombolysis time window into the penumbra with biomarkers, not a stopwatch. 8 Sep 2009
- Neuroprotective effects of estrogen therapy for cognitive and neurobiological profiles of monkey models of menopause. 30 Aug 2009
- Simvastatin therapy prevents brain trauma-induced increases in beta-amyloid peptide levels. 30 Aug 2009
- Effect of Mg2+ on neural activity of rat cortical and hippocampal neurons in vitro. 30 Aug 2009
- MgSO4 treatment preserves the ischemia-induced reduction in S-100 protein without modification of the expression of endothelial tight junction molecules. 30 Aug 2009
- Desflurane, isoflurane, and sevoflurane provide limited neuroprotection against neonatal hypoxia-ischemia in a delayed preconditioning paradigm. 30 Aug 2009
- Deep hypothermia attenuates microglial proliferation independent of neuronal death after prolonged cardiac arrest in rats. 30 Aug 2009
- Physical activity: one of the easiest ways to protect the brain? 30 Aug 2009
- Neuroprotection by a novel NMDAR functional glycine site partial agonist, GLYX-13. 24 Aug 2009
- Protection of neurons derived from human neural progenitor cells by veratridine. 24 Aug 2009
See a longer list of these articles.
Technical information about 'Neuroprotective Agents'
Definition: Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Registry Number: 0
Descriptor UI: D018696
Alternative terms: Neuroprotective Agents; Agents, Neuroprotective; Neuroprotectants; Neuroprotective Drugs; Drugs, Neuroprotective;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;
Tree Number: D27.505.696.706.548; D27.505.954.427.575;
History Note: 95
Technical Notes: GEN or unspecified; prefer specifics; prevent brain & spinal cord damage in neurol dis