 |
Neuroprotective Agents - Therapeutic use
Research News and Information
Definition of 'Neuroprotective Agents'Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. Common names: Neuroprotective Agents; Agents, Neuroprotective; Neuroprotectants; Neuroprotective Drugs; Drugs, Neuroprotective |
Saturday, November 21, 2009
Vincristine: Can its therapeutic index be enhanced?
13 Dec 2009 
Vincristine is one of the most widely used and more effective drugs in paediatric oncology. The dose-limiting toxicity of neuropathy, lack of proven neuroprotective measures and an incomplete understanding of the pharmacokinetics and ... Read more...
2 Nov 2009 Caspases play an important role as mediators of cell death in acute and chronic neurological disorders. Although peptide inhibitors of caspases provide neuroprotection, they have to be administered intracerebroventricularly because they cannot cross ... Read more...
Nov 2009 OBJECTIVE: To investigate the incidence of and risk factors for cognitive impairment in a large, well-defined clinical trial cohort of patients with early Parkinson disease (PD). METHODS: The Mini-Mental State Examination (MMSE) was administered ... Read more...
Latest indexed articles for 'Neuroprotective Agents - Therapeutic use'
These are the very latest articles for this heading:
- Vincristine: Can its therapeutic index be enhanced? 13 Dec 2009
- A nanomedicine transports a peptide caspase-3 inhibitor across the blood-brain barrier and provides neuroprotection. 2 Nov 2009
- Incidence of and risk factors for cognitive impairment in an early Parkinson disease clinical trial cohort. Nov 2009
- Disruption of the axon initial segment cytoskeleton is a new mechanism for neuronal injury. 19 Oct 2009
- Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. 17 Oct 2009
- The delayed-start study design.
22 Sep 2009 - A secretory phospholipase A2-mediated neuroprotection and anti-apoptosis. 21 Sep 2009
- Motoneuron transplantation rescues the phenotype of SMARD1 (spinal muscular atrophy with respiratory distress type 1). 21 Sep 2009
- Pharmacologic interventions for stroke: looking beyond the thrombolysis time window into the penumbra with biomarkers, not a stopwatch. 8 Sep 2009
- Topiramate concentrations in neonates treated with prolonged whole body hypothermia for hypoxic ischemic encephalopathy. 8 Sep 2009
- Protective effect of transgenic expression of porcine heat shock protein 70 on hypothalamic ischemic and oxidative damage in a mouse model of heatstroke. Sep 2009
- Neuroprotection in a 6-hydroxydopamine-lesioned Parkinson model using lactoferrin-modified nanoparticles. 30 Aug 2009
- Simvastatin therapy prevents brain trauma-induced increases in beta-amyloid peptide levels. 30 Aug 2009
- Possible neuroprotective effect of brimonidine in a mouse model of ischaemic optic neuropathy. 30 Aug 2009
- Magnesium in acute and chronic brain injury: an update. 30 Aug 2009
- Magnesium in subarachnoid haemorrhage: proven beneficial? 30 Aug 2009
- Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease. 30 Aug 2009
- Be careful what you train for. 30 Aug 2009
- Physical activity: one of the easiest ways to protect the brain? 30 Aug 2009
- The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia. 27 Aug 2009
See a longer list of these articles.
Technical information about 'Neuroprotective Agents'
Definition: Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Registry Number: 0
Descriptor UI: D018696
Alternative terms: Neuroprotective Agents; Agents, Neuroprotective; Neuroprotectants; Neuroprotective Drugs; Drugs, Neuroprotective;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;
Tree Number: D27.505.696.706.548; D27.505.954.427.575;
History Note: 95
Technical Notes: GEN or unspecified; prefer specifics; prevent brain & spinal cord damage in neurol dis