Neuroprotective Agents
Research News and Information

Saturday, November 21, 2009

Vincristine: Can its therapeutic index be enhanced?

13 Dec 2009 Vincristine is one of the most widely used and more effective drugs in paediatric oncology. The dose-limiting toxicity of neuropathy, lack of proven neuroprotective measures and an incomplete understanding of the pharmacokinetics and ... Read more...

p38SJ, a novel DINGG protein protects neuronal cells from alcohol induced injury and death.

29 Nov 2009 Ethanol induces neuronal cell injury and death by dysregulating several signaling events that are controlled, in part, by activation of MAPK/ERK1/2 and/or inactivation of its corresponding phosphatase, PP1. Recently, we have purified a novel protein ... Read more...

Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosis.

2 Nov 2009 Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease inherited in a small subset of patients. The SOD1(G93A) transgenic mouse models this subset of patients, and studies of this strain have suggested that endoplasmic reticulum (ER) ... Read more...

Latest indexed articles for 'Neuroprotective Agents'

These are the very latest articles for this heading:

• Vincristine: Can its therapeutic index be enhanced? 13 Dec 2009
• p38SJ, a novel DINGG protein protects neuronal cells from alcohol induced injury and death. 29 Nov 2009
• Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosis. 2 Nov 2009
• A nanomedicine transports a peptide caspase-3 inhibitor across the blood-brain barrier and provides neuroprotection. 2 Nov 2009
• Incidence of and risk factors for cognitive impairment in an early Parkinson disease clinical trial cohort. Nov 2009
• Volatile anesthetics attenuate oxidative stress-reduced activity of glutamate transporter type 3. 30 Oct 2009
• Propofol inhibits aquaporin 4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral ischemia/reoxygenation. 30 Oct 2009
• Disruption of the axon initial segment cytoskeleton is a new mechanism for neuronal injury. 19 Oct 2009
• Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. 17 Oct 2009
• Lycopene modulates nitric oxide pathways against 3-nitropropionic acid-induced neurotoxicity. 10 Oct 2009
• mTOR signaling in epileptogenesis: too much of a good thing? 5 Oct 2009
• Neuroprotective role of curcumin in the cerebellum of streptozotocin-induced diabetic rats. Oct 2009
• Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord. 29 Sep 2009
• Differential effects of topiramate on prefrontal glutamatergic transmission when combined with raclopride or clozapine. 29 Sep 2009
• The delayed-start study design. 22 Sep 2009
• A double-blind, delayed-start trial of rasagiline in Parkinson's disease. 22 Sep 2009
• A secretory phospholipase A2-mediated neuroprotection and anti-apoptosis. 21 Sep 2009
• Motoneuron transplantation rescues the phenotype of SMARD1 (spinal muscular atrophy with respiratory distress type 1). 21 Sep 2009
• Evaluation of the protective role of melatonin on the behavioral effects of aluminum in a mouse model of Alzheimer's disease. 17 Sep 2009
• Does high dose methylprednisolone sodium succinate really improve neurological status in patient with acute cervical cord injury?: a prospective study about neurological recovery and early complications. 13 Sep 2009

See a longer list of these articles.

Technical information about 'Neuroprotective Agents'

Definition: Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.

Registry Number: 0

Descriptor UI: D018696

Alternative terms: Neuroprotective Agents; Agents, Neuroprotective; Neuroprotectants; Neuroprotective Drugs; Drugs, Neuroprotective;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D27.505.696.706.548; D27.505.954.427.575;

History Note: 95

Technical Notes: GEN or unspecified; prefer specifics; prevent brain & spinal cord damage in neurol dis