Neurotoxins - Toxicity
Research News and Information

Sunday, November 22, 2009

Lycopene modulates nitric oxide pathways against 3-nitropropionic acid-induced neurotoxicity.

10 Oct 2009 AIM: The present study has been designed to investigate the involvement of the nitric oxide mechanism in the protective effect of lycopene against 3-nitropropionic acid-induced Huntington's disease-like symptoms in rats. MAIN METHODS: The present ... Read more...

Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord.

29 Sep 2009 Glutamate receptor-mediated excitotoxicity and mitochondrial dysfunction appear to play an important role in motoneuron (MN) degeneration in amyotrophic lateral sclerosis (ALS). In the present study we used an organotypic slice culture of chick ... Read more...

Development of microglia in the chick embryo spinal cord: implications in the regulation of motoneuronal survival and death.

13 Aug 2009 The role of microglia during normal development of the nervous system is still not well understood. In the present study, a chick embryo model was used to examine the development of microglia in the spinal cord and characterize their changes in ... Read more...

Latest indexed articles for 'Neurotoxins - Toxicity'

These are the very latest articles for this heading:

• Mice with reduced vesicular monoamine storage content display nonmotor features of Parkinson's disease. 12 Oct 2009
• Lycopene modulates nitric oxide pathways against 3-nitropropionic acid-induced neurotoxicity. 10 Oct 2009
• Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord. 29 Sep 2009
• Development of microglia in the chick embryo spinal cord: implications in the regulation of motoneuronal survival and death. 13 Aug 2009
• NOX2 mediates apoptotic death induced by staurosporine but not by potassium deprivation in cerebellar granule neurons. 13 Aug 2009
• Natural lipophilic inhibitors of mitochondrial complex I are candidate toxins for sporadic neurodegenerative tau pathologies. 11 Aug 2009
• Structure-neurotoxicity relationships of amyloid beta-protein oligomers. 10 Aug 2009
• An extract of Hydrilla verticillata and associated epiphytes induces avian vacuolar myelinopathy in laboratory mallards. 30 Jul 2009
• Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection. 26 Jul 2009
• Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization. 18 Jul 2009
• Experimental conditions substantially influence botulinum toxin potency testing. 29 Jun 2009
• Contribution of a mitochondrial pathway to excitotoxic neuronal necrosis. 29 Jun 2009
• Possible protection by notoginsenoside R1 against glutamate neurotoxicity mediated by N-methyl-D-aspartate receptors composed of an NR1/NR2B subunit assembly. 29 Jun 2009
• Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease. 26 Jun 2009
• Contribution of in vitro neurotoxicology studies to the elucidation of neurodegenerative processes. 22 Jun 2009
• Hypothermic inhibition of apoptotic pathways for combined neurotoxicity of iron and ascorbic acid in differentiated PC12 cells: reduction of oxidative stress and maintenance of the glutathione redox state. 10 Jun 2009
• Regional differences between grey and white matter in cuprizone induced demyelination. 10 Jun 2009
• Regulated expression of surface AMPA receptors reduces excitotoxicity in auditory neurons. 8 Jun 2009
• Effect of dioxins on regulation of tyrosine hydroxylase gene expression by aryl hydrocarbon receptor: a neurotoxicology study. 4 Jun 2009
• HARMFUL ALGAL BLOOMS: an unexpected deep-sea diver. 30 May 2009

See a longer list of these articles.

Technical information about 'Neurotoxins'

Definition: Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept.

Registry Number: 0

Descriptor UI: D009498

Alternative terms: Neurotoxins; Alpha-Neurotoxins; Alpha Neurotoxins; Excitotoxins; Excitotoxin; Excitatory Neurotoxins; Neurotoxins, Excitatory;

Related Mesh Headings: Neurotransmitter Agents;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D27.888.569.504;

History Note: 78

Technical Notes: /antag permitted but consider also ANTITOXINS; coordinate IM with toxin or venom heading which is the source of the neurotoxin (IM or NIM); do not use for neurotoxicity of various chemicals & drugs ( = NERVOUS SYSTEM /drug eff or specific nervous system term /drug eff or nervous system disease heading /chem ind + Category D term /adv eff-pois-tox)