Neurotoxins
Research News and Information

Saturday, November 21, 2009

Lycopene modulates nitric oxide pathways against 3-nitropropionic acid-induced neurotoxicity.

10 Oct 2009 AIM: The present study has been designed to investigate the involvement of the nitric oxide mechanism in the protective effect of lycopene against 3-nitropropionic acid-induced Huntington's disease-like symptoms in rats. MAIN METHODS: The present ... Read more...

Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord.

29 Sep 2009 Glutamate receptor-mediated excitotoxicity and mitochondrial dysfunction appear to play an important role in motoneuron (MN) degeneration in amyotrophic lateral sclerosis (ALS). In the present study we used an organotypic slice culture of chick ... Read more...

Two disaccharides and trimethylamine N-oxide affect Abeta aggregation differently, but all attenuate oligomer-induced membrane permeability.

20 Sep 2009 Interaction between aggregates of amyloid beta protein (Abeta) and membranes has been hypothesized by many to be a key event in the mechanism of neurotoxicity associated with Alzheimer's disease (AD). Proposed membrane-related mechanisms of ... Read more...

Latest indexed articles for 'Neurotoxins'

These are the very latest articles for this heading:

• Mice with reduced vesicular monoamine storage content display nonmotor features of Parkinson's disease. 12 Oct 2009
• Lycopene modulates nitric oxide pathways against 3-nitropropionic acid-induced neurotoxicity. 10 Oct 2009
• Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord. 29 Sep 2009
• Quiz page October 2009. Tetramine poisoning. Neurologic symptoms in a dialysis patient after ingesting seafood. 29 Sep 2009
• Two disaccharides and trimethylamine N-oxide affect Abeta aggregation differently, but all attenuate oligomer-induced membrane permeability. 20 Sep 2009
• Occupation and risk of parkinsonism: a multicenter case-control study. 30 Aug 2009
• Isolation, complete amino acid sequence and characterization of a previously unreported post-synaptic neurotoxin - AlphaN3, from the venom of Bungarus candidus. 30 Aug 2009
• Acute and chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administrations elicit similar microglial activation in the substantia nigra of monkeys. 30 Aug 2009
• Peptidergic clock neurons in Drosophila: ion transport peptide and short neuropeptide F in subsets of dorsal and ventral lateral neurons. 30 Aug 2009
• Remote spatial memory and the hippocampus: effect of early and extensive training in the radial maze. 25 Aug 2009
• Evaluation of the adeno-associated virus mediated long-term expression of channelrhodopsin-2 in the mouse retina. 19 Aug 2009
• Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons. 15 Aug 2009
• Development of microglia in the chick embryo spinal cord: implications in the regulation of motoneuronal survival and death. 13 Aug 2009
• NOX2 mediates apoptotic death induced by staurosporine but not by potassium deprivation in cerebellar granule neurons. 13 Aug 2009
• Natural lipophilic inhibitors of mitochondrial complex I are candidate toxins for sporadic neurodegenerative tau pathologies. 11 Aug 2009
• A role for SNAP25 in internalization of kainate receptors and synaptic plasticity. 11 Aug 2009
• Structure-neurotoxicity relationships of amyloid beta-protein oligomers. 10 Aug 2009
• GABAergic transmission to gonadotropin-releasing hormone (GnRH) neurons is regulated by GnRH in a concentration-dependent manner engaging multiple signaling pathways. 3 Aug 2009
• Ca2+-dependent functions in peptidoglycan-stimulated mouse dendritic cells. Aug 2009
• Characterisation of K+ currents in the C8-B4 microglial cell line and their regulation by microglia activating stimuli. Aug 2009

See a longer list of these articles.

Technical information about 'Neurotoxins'

Definition: Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept.

Registry Number: 0

Descriptor UI: D009498

Alternative terms: Neurotoxins; Alpha-Neurotoxins; Alpha Neurotoxins; Excitotoxins; Excitotoxin; Excitatory Neurotoxins; Neurotoxins, Excitatory;

Related Mesh Headings: Neurotransmitter Agents;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D27.888.569.504;

History Note: 78

Technical Notes: /antag permitted but consider also ANTITOXINS; coordinate IM with toxin or venom heading which is the source of the neurotoxin (IM or NIM); do not use for neurotoxicity of various chemicals & drugs ( = NERVOUS SYSTEM /drug eff or specific nervous system term /drug eff or nervous system disease heading /chem ind + Category D term /adv eff-pois-tox)