Neurotransmitter Agents - Secretion
Research News and Information

Monday, March 22, 2010

A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1.

5 Oct 2009 Multidomain scaffolding proteins organize the molecular machinery of neurotransmitter vesicle dynamics during synaptogenesis and synaptic activity. We find that domains of five active zone proteins converge on an interaction node that centers on the ... Read more...

Asynchronous transmitter release from cholecystokinin-containing inhibitory interneurons is widespread and target-cell independent.

7 Sep 2009 Neurotransmitter release at most central synapses is synchronized to the timing of presynaptic action potentials. Here, we show that three classes of depolarization-induced suppression of inhibition-expressing, cholecystokinin (CCK)-containing, ... Read more...

Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release.

2 Sep 2009 Neurotransmitter release is triggered by cooperative Ca2+-binding to the Ca2+-sensor protein synaptotagmin-1. Synaptotagmin-1 contains two C2 domains, referred to as the C2A and C2B domains, that bind Ca2+ with similar properties and affinities. ... Read more...

Latest indexed articles for 'Neurotransmitter Agents - Secretion'

These are the very latest articles for this heading:

• A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1. 5 Oct 2009
• Asynchronous transmitter release from cholecystokinin-containing inhibitory interneurons is widespread and target-cell independent. 7 Sep 2009
• Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release. 2 Sep 2009
• [TRPV1 receptor as a therapeutical target for the treatment of migraine] 30 Jul 2009
• [Application of botulinum neurotoxin in the treatment of epilepsy] 30 Jul 2009
• Mechanical tension contributes to clustering of neurotransmitter vesicles at presynaptic terminals. 18 Jul 2009
• Adenosine suppresses exocytosis from cone terminals of the salamander retina. 29 Jun 2009
• L-aspartate as an amino acid neurotransmitter: mechanisms of the depolarization-induced release from cerebrocortical synaptosomes. 20 Jun 2009
• Graded synaptic transmission at the Caenorhabditis elegans neuromuscular junction. 13 Jun 2009
• Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release. 30 May 2009
• Pool rules. 30 May 2009
• Calibration of neurotransmitter release from neural cells for therapeutic implants. 30 May 2009
• Synapsin I accelerates the kinetics of neurotransmitter release in mouse motor terminals. 30 May 2009
• Synaptotagmin-IV modulates synaptic function and long-term potentiation by regulating BDNF release. 15 May 2009
• A resting pool of vesicles is responsible for spontaneous vesicle fusion at the synapse. 8 May 2009
• [A reminder of the structure and function of the skeletal neuromuscular junction] 29 Apr 2009
• Resistance to D-tubocurarine of the rat diaphragm as compared to a limb muscle: influence of quantal transmitter release and nicotinic acetylcholine receptors. 29 Apr 2009
• Intrahippocampal infusions of anisomycin produce amnesia: contribution of increased release of norepinephrine, dopamine, and acetylcholine. 27 Apr 2009
• Importin 13 regulates neurotransmitter release at the Drosophila neuromuscular junction. 27 Apr 2009
• Action potential modulates Ca2+-dependent and Ca2+-independent secretion in a sensory neuron. 16 Mar 2009

See a longer list of these articles.

Technical information about 'Neurotransmitter Agents'

Definition: Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.

Registry Number: 0

Descriptor UI: D018377

Alternative terms: Neurotransmitter Agents; Agents, Neurotransmitter; Neuromodulators; Neuromodulator; Neurohormones; Neurotransmitters; Transmitter Substances, Nerve; Substances, Nerve Transmitter; Nerve Transmitter Substances; Neurotransmitter; Neurohumors; Neuroregulators; Neuroregulator;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D27.505.519.625; D27.505.696.577;

History Note: 1998; use explode 1995-1997

Technical Notes: general; prefer specifics