Nicotine - Pharmacology
Research News and Information

Sunday, November 22, 2009

Time-dependent exposure of nicotine and smoke modulate ultrasubcellular organelle localization of dopamine D1 and D2 receptors in the rat caudate-putamen.

29 Sep 2009 The correlation of the subcellular localization of dopamine D(1) and D(2) receptors (DA D(1) R, DA D(2) R) with nicotine addiction has not been studied. We demonstrated the ultrasubcellular organelle localization of DA D(1) and D(2) Rs in the ... Read more...

Nicotine activates the chemosensory cation channel TRPA1.

11 Sep 2009 Topical application of nicotine, as used in nicotine replacement therapies, causes irritation of the mucosa and skin. This reaction has been attributed to activation of nicotinic acetylcholine receptors (nAChRs) in chemosensory neurons. In contrast ... Read more...

Dopamine enables in vivo synaptic plasticity associated with the addictive drug nicotine.

8 Sep 2009 Addictive drugs induce a dopamine signal that contributes to the initiation of addiction, and the dopamine signal influences drug-associated memories that perpetuate drug use. The addiction process shares many commonalities with the synaptic ... Read more...

Latest indexed articles for 'Nicotine - Pharmacology'

These are the very latest articles for this heading:

• Time-dependent exposure of nicotine and smoke modulate ultrasubcellular organelle localization of dopamine D1 and D2 receptors in the rat caudate-putamen. 29 Sep 2009
• Nicotine activates the chemosensory cation channel TRPA1. 11 Sep 2009
• Dopamine enables in vivo synaptic plasticity associated with the addictive drug nicotine. 8 Sep 2009
• Nicotine's Allure. 8 Sep 2009
• Cholinergic agonists regulate JAK2/STAT3 signaling to suppress endothelial cell activation. 7 Sep 2009
• Activation of nicotinic acetylcholine receptors enhances a slow calcium-dependent potassium conductance and reduces the firing of stratum oriens interneurons. 2 Sep 2009
• Gene regulation of alpha4beta2 nicotinic receptors: microarray analysis of nicotine-induced receptor up-regulation and anti-inflammatory effects. 30 Aug 2009
• Conceptual DFT properties-based 3D QSAR: analysis of inhibitors of the nicotine metabolizing CYP2A6 enzyme. 30 Aug 2009
• Characterization of a nicotine-sensitive neuronal population in rat entorhinal cortex. 17 Aug 2009
• Nicotine stimulates PPARbeta/delta expression in human lung carcinoma cells through activation of PI3K/mTOR and suppression of AP-2alpha. 2 Aug 2009
• Overexpressed alpha7 nicotinic acetylcholine receptor inhibited proinflammatory cytokine release in NIH3T3 cells. 30 Jul 2009
• Functional alpha 7-containing nicotinic receptors of NG2-expressing cells in the hippocampus. 30 Jul 2009
• Interactions of serotonin (5-HT)2 receptor-targeting ligands and nicotine: locomotor activity studies in rats. 30 Jul 2009
• Expression of a prometastatic splice variant of osteopontin, OPNC, in human pancreatic ductal adenocarcinoma. 30 Jul 2009
• Nicotine can skew the characterization of the macrophage type-1 (MPhi1) phenotype differentiated with granulocyte-macrophage colony-stimulating factor to the MPhi2 phenotype. 27 Jul 2009
• The facilitatory effects of intermittent theta burst stimulation on corticospinal excitability are enhanced by nicotine. 26 Jul 2009
• The novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB), inhibits nicotine-evoked [(3)H]norepinephrine overflow from rat hippocampal slices. 21 Jul 2009
• Induction of osteopontin expression by nicotine and cigarette smoke in the pancreas and pancreatic ductal adenocarcinoma cells. 13 Jul 2009
• Effect of nicotine on the pelvic afferent nerve activity and bladder pressure in rats. 30 Jun 2009
• Enhanced nicotine reward in adulthood after exposure to nicotine during early adolescence in mice. 30 Jun 2009

See a longer list of these articles.

Technical information about 'Nicotine'

Definition: Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Chemical name: Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-

Registry Number: 54-11-5

Descriptor UI: D009538

Alternative terms: Nicotine; Nicotine Tartrate; Tartrate, Nicotine; Nicotine Bitartrate; Bitartrate, Nicotine;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Ganglionic Stimulants; Nicotinic Agonists;

Tree Number: D03.132.760.570; D03.383.725.518;

Technical Notes: /biosyn permitted if by plant