Nicotine
Research News and Information

Saturday, November 21, 2009

Exposure to the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers from 3 populations with different risks of lung cancer.

13 Nov 2009 Native Hawaiian smokers are at higher risk and Japanese-American smokers at lower risk of lung cancer (LC), compared with white smokers, even after accounting for smoking history. Because variation in carcinogen exposure/metabolism may occur ... Read more...

A randomized placebo-controlled clinical trial of 5 smoking cessation pharmacotherapies.

30 Oct 2009 CONTEXT: Little direct evidence exists on the relative efficacies of different smoking cessation pharmacotherapies, yet such evidence is needed to make informed decisions about their clinical use. OBJECTIVE: To assess the relative efficacies of 5 ... Read more...

Chronic nicotine selectively enhances alpha4beta2* nicotinic acetylcholine receptors in the nigrostriatal dopamine pathway.

5 Oct 2009 These electrophysiological experiments, in slices and intact animals, study the effects of in vivo chronic exposure to nicotine on functional alpha4beta2* nAChRs in the nigrostriatal dopaminergic (DA) pathway. Recordings were made in wild-type and ... Read more...

Latest indexed articles for 'Nicotine'

These are the very latest articles for this heading:

• Exposure to the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers from 3 populations with different risks of lung cancer. 13 Nov 2009
• A randomized placebo-controlled clinical trial of 5 smoking cessation pharmacotherapies. 30 Oct 2009
• Chronic nicotine selectively enhances alpha4beta2* nicotinic acetylcholine receptors in the nigrostriatal dopamine pathway. 5 Oct 2009
• Regulation of oxygen sensitivity in adrenal chromaffin cells. 29 Sep 2009
• Varenicline and suicidal behaviour: a cohort study based on data from the General Practice Research Database. 29 Sep 2009
• Smoking cessation: how to advise the patient. 29 Sep 2009
• Time-dependent exposure of nicotine and smoke modulate ultrasubcellular organelle localization of dopamine D1 and D2 receptors in the rat caudate-putamen. 29 Sep 2009
• Nicotine activates the chemosensory cation channel TRPA1. 11 Sep 2009
• Alterations in cholinergic sensitivity of respiratory neurons induced by pre-natal nicotine: a mechanism for respiratory dysfunction in neonatal mice. 10 Sep 2009
• Dopamine enables in vivo synaptic plasticity associated with the addictive drug nicotine. 8 Sep 2009
• Nicotine's Allure. 8 Sep 2009
• Cholinergic agonists regulate JAK2/STAT3 signaling to suppress endothelial cell activation. 7 Sep 2009
• Should the Pharmaceutical Benefits Advisory Committee extend the range of free nicotine replacement therapies available for Aboriginal and Torres Strait Islander people? 5 Sep 2009
• Activation of nicotinic acetylcholine receptors enhances a slow calcium-dependent potassium conductance and reduces the firing of stratum oriens interneurons. 2 Sep 2009
• FDA: Electronic cigarettes may be risky. 31 Aug 2009
• Assessment of attentional function and impulsivity using 5-choice serial reaction time task/3-choice serial reaction time task. 30 Aug 2009
• Gene regulation of alpha4beta2 nicotinic receptors: microarray analysis of nicotine-induced receptor up-regulation and anti-inflammatory effects. 30 Aug 2009
• Conceptual DFT properties-based 3D QSAR: analysis of inhibitors of the nicotine metabolizing CYP2A6 enzyme. 30 Aug 2009
• Sensation seeking as a predictor of treatment compliance and smoking cessation treatment outcomes in heavy social drinkers. 30 Aug 2009
• Treating tobacco dependence in a medical setting. 23 Aug 2009

See a longer list of these articles.

Technical information about 'Nicotine'

Definition: Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Chemical name: Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-

Registry Number: 54-11-5

Descriptor UI: D009538

Alternative terms: Nicotine; Nicotine Tartrate; Tartrate, Nicotine; Nicotine Bitartrate; Bitartrate, Nicotine;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Ganglionic Stimulants; Nicotinic Agonists;

Tree Number: D03.132.760.570; D03.383.725.518;

Technical Notes: /biosyn permitted if by plant