Nicotinic Agonists
Research News and Information

Saturday, March 20, 2010

Main immunogenic region structure promotes binding of conformation-dependent myasthenia gravis autoantibodies, nicotinic acetylcholine receptor conformation maturation, and agonist sensitivity.

2 Nov 2009 The main immunogenic region (MIR) is a conformation-dependent region at the extracellular apex of alpha1 subunits of muscle nicotinic acetylcholine receptor (AChR) that is the target of half or more of the autoantibodies to muscle AChRs in human ... Read more...

Time-dependent exposure of nicotine and smoke modulate ultrasubcellular organelle localization of dopamine D1 and D2 receptors in the rat caudate-putamen.

29 Sep 2009 The correlation of the subcellular localization of dopamine D(1) and D(2) receptors (DA D(1) R, DA D(2) R) with nicotine addiction has not been studied. We demonstrated the ultrasubcellular organelle localization of DA D(1) and D(2) Rs in the ... Read more...

Nicotine activates the chemosensory cation channel TRPA1.

11 Sep 2009 Topical application of nicotine, as used in nicotine replacement therapies, causes irritation of the mucosa and skin. This reaction has been attributed to activation of nicotinic acetylcholine receptors (nAChRs) in chemosensory neurons. In contrast ... Read more...

Latest indexed articles for 'Nicotinic Agonists'

These are the very latest articles for this heading:

• Main immunogenic region structure promotes binding of conformation-dependent myasthenia gravis autoantibodies, nicotinic acetylcholine receptor conformation maturation, and agonist sensitivity. 2 Nov 2009
• Smoking cessation: how to advise the patient. 29 Sep 2009
• Time-dependent exposure of nicotine and smoke modulate ultrasubcellular organelle localization of dopamine D1 and D2 receptors in the rat caudate-putamen. 29 Sep 2009
• Nicotine activates the chemosensory cation channel TRPA1. 11 Sep 2009
• Dopamine enables in vivo synaptic plasticity associated with the addictive drug nicotine. 8 Sep 2009
• Nicotine's Allure. 8 Sep 2009
• Cholinergic agonists regulate JAK2/STAT3 signaling to suppress endothelial cell activation. 7 Sep 2009
• Gene regulation of alpha4beta2 nicotinic receptors: microarray analysis of nicotine-induced receptor up-regulation and anti-inflammatory effects. 30 Aug 2009
• Nicotinic plant poisoning. 30 Aug 2009
• Behavioral interventions in tobacco dependence. 30 Aug 2009
• Sensation seeking as a predictor of treatment compliance and smoking cessation treatment outcomes in heavy social drinkers. 30 Aug 2009
• Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor. 18 Aug 2009
• [Cognitive modifications associated with tobacco smoking] 5 Aug 2009
• Evaluation of alpha7 nicotinic acetylcholine receptor agonists and positive allosteric modulators using the parallel oocyte electrophysiology test station. 30 Jul 2009
• Nicotine replacement therapy during pregnancy: recommended or not recommended? 30 Jul 2009
• Quitting smoking is easy...Mark Twain said so. 30 Jul 2009
• Tobacco treatment and prevention: what works and why. 30 Jul 2009
• Overexpressed alpha7 nicotinic acetylcholine receptor inhibited proinflammatory cytokine release in NIH3T3 cells. 30 Jul 2009
• Functional alpha 7-containing nicotinic receptors of NG2-expressing cells in the hippocampus. 30 Jul 2009
• Interactions of serotonin (5-HT)2 receptor-targeting ligands and nicotine: locomotor activity studies in rats. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Nicotinic Agonists'

Definition: Drugs that bind to and activate nicotinic cholinergic receptors (RECEPTORS, NICOTINIC). Nicotinic agonists act at postganglionic nicotinic receptors, at neuroeffector junctions in the peripheral nervous system, and at nicotinic receptors in the central nervous system. Agents that function as neuromuscular depolarizing blocking agents are included here because they activate nicotinic receptors, although they are used clinically to block nicotinic transmission.

Registry Number: 0

Descriptor UI: D018722

Alternative terms: Nicotinic Agonists; Agonists, Nicotinic; Nicotinic Agonist; Agonist, Nicotinic; Cholinergic Agonist, Nicotinic; Agonist, Nicotinic Cholinergic; Nicotinic Cholinergic Agonist; Cholinergic Agonists, Nicotinic; Agonists, Nicotinic Cholinergic; Nicotinic Cholinergic Agonists;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications;

Tree Number: D27.505.519.625.120.140.700; D27.505.696.577.120.140.700;

History Note: 95

Technical Notes: GEN or unspecified; prefer specifics; DF: NICOTINIC AGON or NICOTINIC AG