Nitric Oxide Synthase - Antagonists & inhibitors
Research News and Information

Sunday, March 21, 2010

EPR and ENDOR characterization of the reactive intermediates in the generation of NO by cryoreduced oxy-nitric oxide synthase from Geobacillus stearothermophilus.

12 Oct 2009 Cryoreduction EPR/ENDOR/step-annealing measurements with substrate complexes of oxy-gsNOS (3; gsNOS is nitric oxide synthase from Geobacillus stearothermophilus) confirm that Compound I (6) is the reactive heme species that carries out the ... Read more...

Predictors of 30-day mortality in patients with refractory cardiogenic shock following acute myocardial infarction despite a patent infarct artery.

29 Sep 2009 BACKGROUND: Little is known about predictors of survival in patients with persistent shock following acute myocardial infarction (MI) despite a patent infarct artery. METHODS: We examined data from TRIUMPH, a multicenter randomized clinical trial of ... Read more...

Inhibitory effects of honokiol on LPS and PMA-induced cellular responses of macrophages and monocytes.

28 Sep 2009 The regulatory effects of honokiol on the cellular responses of macrophages and monocytes were evaluated. Specifically, we investigated the effects of honokiol with respect to lipopolysaccharide (LPS)-induced cytotoxicity, LPS- or ... Read more...

Latest indexed articles for 'Nitric Oxide Synthase - Antagonists & inhibitors'

These are the very latest articles for this heading:

• EPR and ENDOR characterization of the reactive intermediates in the generation of NO by cryoreduced oxy-nitric oxide synthase from Geobacillus stearothermophilus. 12 Oct 2009
• Predictors of 30-day mortality in patients with refractory cardiogenic shock following acute myocardial infarction despite a patent infarct artery. 29 Sep 2009
• Inhibitory effects of honokiol on LPS and PMA-induced cellular responses of macrophages and monocytes. 28 Sep 2009
• Ghrelin restores the endothelin 1/nitric oxide balance in patients with obesity-related metabolic syndrome. 26 Sep 2009
• Ex-vivo detection of neural events using THz BioMEMS. 30 Aug 2009
• Asymmetric dimethylarginine endogenous inhibition of nitric oxide synthase causes differential vasculature effects. 30 Aug 2009
• Chronic treatment of hydroxytryptamine type 2a receptor antagonist sarpogrelate hydrochloride modulates the vasoreactivity of serotonin in experimental rabbit vein grafts. 30 Aug 2009
• Reflex vasoconstriction in aged human skin increasingly relies on Rho kinase-dependent mechanisms during whole body cooling. 26 Aug 2009
• Nitric oxide regulates lung carcinoma cell anoikis through inhibition of ubiquitin-proteasomal degradation of caveolin-1. 23 Aug 2009
• Nitric oxide and pain: 'Something old, something new'. 19 Aug 2009
• The role of nitric oxide in the development of neurogenic pulmonary edema in spinal cord-injured rats: the effect of preventive interventions. 10 Aug 2009
• Involvement of nitric oxide synthesis in sensitization to the rewarding effects of morphine. 9 Aug 2009
• Intercellular communication of cellular stress monitored by gamma-H2AX induction. Aug 2009
• Vascular endothelial growth factor inhibitors and hypertension: a central role for the kidney and endothelial factors? Aug 2009
• [NO-ergic system activation in the nucleus accumbens during presentation of contextual signals of danger] 30 Jul 2009
• Influence of L-arginine on the nitric oxide concentration and level of oxidative stress during ischemia-reperfusion injury in a rat model. 30 Jul 2009
• Orthostatic responses to nitric oxide synthase inhibition in persons with tetraplegia. 30 Jul 2009
• Vascular smooth muscle modulates endothelial control of vasoreactivity via reactive oxygen species production through myoendothelial communications. 28 Jul 2009
• Sodium tanshinone IIA sulfonate increased intestinal hemodynamics without systemic circulatory changes in healthy newborn piglets. 15 Jul 2009
• Effects of galantamine on L-NAME-induced behavioral impairment in Y-maze task in mice. 13 Jul 2009

See a longer list of these articles.

Technical information about 'Nitric Oxide Synthase'

Definition: An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.

Chemical name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)

Registry Number: EC 1.14.13.39

Descriptor UI: D019001

Alternative terms: Nitric Oxide Synthase; Oxide Synthase, Nitric; Synthase, Nitric Oxide; Nitric-Oxide Synthetase; Nitric Oxide Synthetase; NO Synthase; Nitric-Oxide Synthase;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.682.664.500.772;

History Note: 2006(1990)

Technical Notes: general; prefer specifics