Nitric Oxide Synthase Type III - Antagonists & inhibitors
Research News and Information

Monday, November 23, 2009

eNOS uncoupling and endothelial dysfunction in aged vessels.

16 Sep 2009 Endothelial nitric oxide synthase (eNOS) uncoupling is a mechanism that leads to endothelial dysfunction. Previously, we reported that shear stress-induced release of nitric oxide in vessels of aged rats was significantly reduced and was accompanied ... Read more...

Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery.

28 Aug 2009 Here we show that ischemia induces sustained contraction of pericytes on microvessels in the intact mouse brain. Pericytes remain contracted despite successful reopening of the middle cerebral artery after 2 h of ischemia. Pericyte contraction ... Read more...

Nitrite enhances RBC hypoxic ATP synthesis and the release of ATP into the vasculature: a new mechanism for nitrite-induced vasodilation.

19 Aug 2009 A role for nitric oxide (NO) produced during the reduction of nitrite by deoxygenated red blood cells (RBCs) in regulating vascular dilation has been proposed. It has not, however, been satisfactorily explained how this NO is released from the RBC ... Read more...

Latest indexed articles for 'Nitric Oxide Synthase Type III - Antagonists & inhibitors'

These are the very latest articles for this heading:

• eNOS uncoupling and endothelial dysfunction in aged vessels. 16 Sep 2009
• Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery. 28 Aug 2009
• Nitrite enhances RBC hypoxic ATP synthesis and the release of ATP into the vasculature: a new mechanism for nitrite-induced vasodilation. 19 Aug 2009
• In vivo human lower extremity saphenous vein bypass grafts manifest flow mediated vasodilation. 10 Aug 2009
• Phasic contractions of rat mesenteric lymphatics increase basal and phasic nitric oxide generation in vivo. 5 Aug 2009
• Transfer of nitric oxide by blood from upstream to downstream resistance vessels causes microvascular dilation. 5 Aug 2009
• Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression. Aug 2009
• Vascular endothelial growth factor inhibitors and hypertension: a central role for the kidney and endothelial factors? Aug 2009
• Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring study. 28 Jul 2009
• Valsartan improves endothelial dysfunction in hypertension: a randomized, double-blind study. 12 Jul 2009
• [Nitrogen monoxide and functional activity of large conductance Ca-activated potassium channels in coronary vessels in rats with limited motor activity] 29 Jun 2009
• Effect of melatonin and vitamin C on expression of endothelial NOS in heart of chronic alcoholic rats. 29 Jun 2009
• Akt1 mediates purinergic-dependent NOS3 activation in thick ascending limbs. 29 Jun 2009
• Basal nitric oxide release attenuates cell migration of HeLa and endothelial cells. 23 Jun 2009
• Lysozyme, a mediator of sepsis that intrinsically generates hydrogen peroxide to cause cardiovascular dysfunction. 17 Jun 2009
• Differential structural and functional changes in penile and coronary arteries from obese Zucker rats. 17 Jun 2009
• Role of gender and estrogen receptors in the rat aorta endothelium-dependent relaxation to red wine polyphenols. 7 Jun 2009
• No evidence for an enhanced role of endothelial nitric oxide in the maintenance of arterial blood pressure in the IUGR sheep fetus. 7 Jun 2009
• LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells. 30 May 2009
• A study of endothelial function and circulating asymmetric dimethylarginine levels in people with Type 1 diabetes without macrovascular disease or microalbuminuria. 30 May 2009

See a longer list of these articles.

Technical information about 'Nitric Oxide Synthase Type III'

Definition: A CALCIUM-dependent, constitutively-expressed form of nitric acid synthase found primarily in ENDOTHELIAL CELLS.

Registry Number: EC 1.14.13.39

Descriptor UI: D052250

Alternative terms: Nitric Oxide Synthase Type III; Nitric Oxide Synthase, Type III; Endothelial Nitric Oxide Synthase; ENOS Enzyme; ECNOS Enzyme; Endothelial Constitutive Nitric Oxide Synthase;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.682.664.500.772.750;

History Note: 2006(1998)