Nitriles - Pharmacology
Research News and Information

Saturday, November 21, 2009

Inhibition of constitutive and cxc-chemokine-induced NF-kappaB activity potentiates ansamycin-based HSP90-inhibitor cytotoxicity in castrate-resistant prostate cancer cells.

4 Oct 2009 BACKGROUND: We determined how CXC-chemokine signalling and necrosis factor-kappaB (NF-kappaB) activity affected heat-shock protein 90 (Hsp90) inhibitor (geldanamycin (GA) and 17-allylamino-demethoxygeldanamycin (17-AAG)) cytotoxicity in ... Read more...

Assessing the impact of indoor residual spraying on malaria morbidity using a sentinel site surveillance system in Western Uganda.

29 Sep 2009 A single round of indoor residual spraying (IRS) using lambda-cyhalothrin was implemented in a district of Uganda with moderate transmission intensity in 2007. Individual patient data were collected from one health facility within the district 8 ... Read more...

Activation of extracellular signal-regulated kinase in sciatic nerve contributes to neuropathic pain after partial sciatic nerve ligation in mice.

29 Sep 2009 BACKGROUND: The mitogen-activated protein kinase family plays an important role in several types of pain. However, the detailed role of phosphorylated extracellular signal-regulated kinase (pERK) in the region of injured peripheral nerve is poorly ... Read more...

Latest indexed articles for 'Nitriles - Pharmacology'

These are the very latest articles for this heading:

• Inhibition of constitutive and cxc-chemokine-induced NF-kappaB activity potentiates ansamycin-based HSP90-inhibitor cytotoxicity in castrate-resistant prostate cancer cells. 4 Oct 2009
• Assessing the impact of indoor residual spraying on malaria morbidity using a sentinel site surveillance system in Western Uganda. 29 Sep 2009
• Activation of extracellular signal-regulated kinase in sciatic nerve contributes to neuropathic pain after partial sciatic nerve ligation in mice. 29 Sep 2009
• Sevoflurane preconditioning induces rapid ischemic tolerance against spinal cord ischemia/reperfusion through activation of extracellular signal-regulated kinase in rabbits. 29 Sep 2009
• Down-regulation of HLA Class I and NKG2D ligands through a concerted action of MAPK and DNA methyltransferases in colorectal cancer cells. 29 Sep 2009
• Effects of morphine on testosterone levels in rat C6 glioma cells: modulation by anastrozole. 29 Sep 2009
• Growth factor-antagonized rexinoid apoptosis involves permissive PPARgamma/RXR heterodimers to activate the intrinsic death pathway by NO. 6 Sep 2009
• Adaptation and evaluation of the bottle assay for monitoring insecticide resistance in disease vector mosquitoes in the Peruvian Amazon. Sep 2009
• Fyn kinase activity is required for normal organization and functional polarity of the mouse oocyte cortex. 30 Aug 2009
• Early zygotic expression of transcription factors and signal molecules in fully dissociated embryonic cells of Ciona intestinalis: A microarray analysis. 30 Aug 2009
• Oxidative stress induces anti-hepatitis C virus status via the activation of extracellular signal-regulated kinase. 30 Aug 2009
• Long-term potentiation in the rat medial vestibular nuclei depends on locally synthesized 17beta-estradiol. 24 Aug 2009
• Beta-amyloid monomers are neuroprotective. 24 Aug 2009
• TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling. 15 Aug 2009
• Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34+-derived neutrophil progenitors. 8 Aug 2009
• Status of insecticide susceptibility in Anopheles gambiae s.l. from malaria surveillance sites in The Gambia. 3 Aug 2009
• Mechanistic study on growth suppression and apoptosis induction by targeting hepatoma-derived growth factor in human hepatocellular carcinoma HepG2 cells. Aug 2009
• Insecticide-induced changes in protein, RNA, and DNA contents in ovary and fat body of female Nilaparvata lugens (Hemiptera: Delphacidae). 30 Jul 2009
• Dipeptidyl peptidase 2 is an essential survival factor in the regulation of cell quiescence. 30 Jul 2009
• Prolactin induces chitotriosidase expression in human macrophages through PTK, PI3-K, and MAPK pathways. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Nitriles'

Definition: Organic compounds containing the -CN radical. The concept is distinguished from CYANIDES, which denotes inorganic salts of HYDROGEN CYANIDE.

Registry Number: 0

Descriptor UI: D009570

Alternative terms: Nitriles;

Related Mesh Headings: Cyanides;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.626;

Online Note: use CYANIDES to search NITRILES 1966-67

History Note: 68; was see under CYANIDES 1963-67

Technical Notes: organic cpds having -CN radical: differentiate from CYANIDES which are inorganic with -CN