Nitriles
Research News and Information

Sunday, November 22, 2009

Dynamic asymmetric multicomponent resolution: lipase-mediated amidation of a double dynamic covalent system.

12 Oct 2009 The Strecker reaction is one of the most important multicomponent reactions developed, leading to alpha-aminonitriles that are versatile substrates for many synthetic applications. In the present study, this reaction type has been applied to a ... Read more...

Molecular dynamics study of non-nucleoside reverse transcriptase inhibitor 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile (TMC278/rilpivirine) aggregates: correlation between amphiphilic properties of the drug and oral bioavailability.

6 Oct 2009 The non-nucleoside reverse transcriptase inhibitor (NNRTI) TMC278/rilpivirine is an anti-AIDS therapeutic agent with high oral bioavailability despite its high hydrophobicity. Previous studies established a correlation between ability of the drug ... Read more...

Inhibition of constitutive and cxc-chemokine-induced NF-kappaB activity potentiates ansamycin-based HSP90-inhibitor cytotoxicity in castrate-resistant prostate cancer cells.

4 Oct 2009 BACKGROUND: We determined how CXC-chemokine signalling and necrosis factor-kappaB (NF-kappaB) activity affected heat-shock protein 90 (Hsp90) inhibitor (geldanamycin (GA) and 17-allylamino-demethoxygeldanamycin (17-AAG)) cytotoxicity in ... Read more...

Latest indexed articles for 'Nitriles'

These are the very latest articles for this heading:

• Dynamic asymmetric multicomponent resolution: lipase-mediated amidation of a double dynamic covalent system. 12 Oct 2009
• Molecular dynamics study of non-nucleoside reverse transcriptase inhibitor 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile (TMC278/rilpivirine) aggregates: correlation between amphiphilic properties of the drug and oral bioavailability. 6 Oct 2009
• Inhibition of constitutive and cxc-chemokine-induced NF-kappaB activity potentiates ansamycin-based HSP90-inhibitor cytotoxicity in castrate-resistant prostate cancer cells. 4 Oct 2009
• Assessing the impact of indoor residual spraying on malaria morbidity using a sentinel site surveillance system in Western Uganda. 29 Sep 2009
• Genotoxic and oxidative stress-inducing effects of deltamethrin in the erythrocytes of a freshwater biomarker fish species, Channa punctata Bloch. 29 Sep 2009
• Activation of extracellular signal-regulated kinase in sciatic nerve contributes to neuropathic pain after partial sciatic nerve ligation in mice. 29 Sep 2009
• Sevoflurane preconditioning induces rapid ischemic tolerance against spinal cord ischemia/reperfusion through activation of extracellular signal-regulated kinase in rabbits. 29 Sep 2009
• Down-regulation of HLA Class I and NKG2D ligands through a concerted action of MAPK and DNA methyltransferases in colorectal cancer cells. 29 Sep 2009
• Effects of morphine on testosterone levels in rat C6 glioma cells: modulation by anastrozole. 29 Sep 2009
• Interpretation of p-cyanophenylalanine fluorescence in proteins in terms of solvent exposure and contribution of side-chain quenchers: a combined fluorescence, IR and molecular dynamics study. 27 Sep 2009
• Isocyanides inhibit human heme oxygenases at the verdoheme stage. 20 Sep 2009
• Growth factor-antagonized rexinoid apoptosis involves permissive PPARgamma/RXR heterodimers to activate the intrinsic death pathway by NO. 6 Sep 2009
• Adaptation and evaluation of the bottle assay for monitoring insecticide resistance in disease vector mosquitoes in the Peruvian Amazon. Sep 2009
• In vitro degradation of a biodegradable polyurethane foam, based on 1,4-butanediisocyanate: a three-year study at physiological and elevated temperature. 30 Aug 2009
• [Safety and compliance with UFT (tegafur and uracil) alone and in combination with hormone therapy in patients with breast cancer] 30 Aug 2009
• Fyn kinase activity is required for normal organization and functional polarity of the mouse oocyte cortex. 30 Aug 2009
• In vivo quantification of regional dopamine-D3 receptor binding potential of (+)-PHNO: Studies in non-human primates and transgenic mice. 30 Aug 2009
• Early zygotic expression of transcription factors and signal molecules in fully dissociated embryonic cells of Ciona intestinalis: A microarray analysis. 30 Aug 2009
• Oxidative stress induces anti-hepatitis C virus status via the activation of extracellular signal-regulated kinase. 30 Aug 2009
• How to overcome limitations in biotechnological processes - examples from hydroxynitrile lyase applications. 25 Aug 2009

See a longer list of these articles.

Technical information about 'Nitriles'

Definition: Organic compounds containing the -CN radical. The concept is distinguished from CYANIDES, which denotes inorganic salts of HYDROGEN CYANIDE.

Registry Number: 0

Descriptor UI: D009570

Alternative terms: Nitriles;

Related Mesh Headings: Cyanides;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.626;

Online Note: use CYANIDES to search NITRILES 1966-67

History Note: 68; was see under CYANIDES 1963-67

Technical Notes: organic cpds having -CN radical: differentiate from CYANIDES which are inorganic with -CN