Nociceptors - Physiopathology
Research News and Information

Tuesday, November 24, 2009

Reactive oxygen species derived from NOX1/NADPH oxidase enhance inflammatory pain.

15 Sep 2008 The involvement of reactive oxygen species (ROS) in an augmented sensitivity to painful stimuli (hyperalgesia) during inflammation has been suggested, yet how and where ROS affect the pain signaling remain unknown. Here we report a novel role for ... Read more...

Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy.

7 Sep 2008 The neurotoxic effects of catecholamine metabolites have been implicated in neurodegenerative diseases. As some sensory neurons express tyrosine hydroxylase and monoamine oxidase (MAO), we investigated the potential contribution of catecholamine ... Read more...

Impact of depressive symptoms on visceral sensitivity among patients with different subtypes of irritable bowel syndrome.

30 Aug 2008 The etiology of irritable bowel syndrome (IBS) is complex and multifaceted. Psychosocial factors play a role in such a process. Several reports suggest that IBS patients have increased psychopathology scores as compared with population controls. The ... Read more...

Latest indexed articles for 'Nociceptors - Physiopathology'

These are the very latest articles for this heading:

• Reactive oxygen species derived from NOX1/NADPH oxidase enhance inflammatory pain. 15 Sep 2008
• Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy. 7 Sep 2008
• Botulinum toxin type A treatment of painful focal neuropathies: new evidence for efference of afferents. 30 Aug 2008
• Impact of depressive symptoms on visceral sensitivity among patients with different subtypes of irritable bowel syndrome. 30 Aug 2008
• cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I. 18 Aug 2008
• Genistein, a natural phytoestrogen from soy, relieves neuropathic pain following chronic constriction sciatic nerve injury in mice: anti-inflammatory and antioxidant activity. 6 Aug 2008
• Antinociceptive effects of tumor necrosis factor alpha neutralization in a rat model of antigen-induced arthritis: evidence of a neuronal target. 30 Jul 2008
• Modeling of nociceptor transduction in skin thermal pain sensation. 30 Jul 2008
• [Elektrophysiological methods as diagnostic tools in pain therapy] 30 Jul 2008
• Mechanisms of pain in nonmalignant disease. 30 May 2008
• Recent advances in chronic visceral pain. 30 May 2008
• Tactile-induced ultrasonic vocalization in the rat: a novel assay to assess anti-migraine therapies in vivo. 19 May 2008
• Sex differences in thermal pain sensitivity and sympathetic reactivity for two strains of rat. 14 May 2008
• Ethnic differences in diffuse noxious inhibitory controls. 12 May 2008
• Electrical low-frequency stimulation induces homotopic long-term depression of nociception and pain from hand in man. 10 May 2008
• Inflammation-induced shift in the valence of spinal GABA-A receptor-mediated modulation of nociception in the adult rat. 5 May 2008
• Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. 5 May 2008
• Molecular mechanisms of sensitization of pain-transducing P2X3 receptors by the migraine mediators CGRP and NGF. 4 May 2008
• Involvement of TRPV1 in nociceptive behavior in a rat model of cancer pain. 30 Apr 2008
• Pain perception in the elderly patient. 29 Apr 2008

See a longer list of these articles.

Technical information about 'Nociceptors'

Definition: Peripheral AFFERENT NEURONS which are sensitive to injuries or pain, usually caused by extreme thermal exposures, mechanical forces, or other noxious stimuli. Their cell bodies reside in the DORSAL ROOT GANGLIA. Their peripheral terminals (NERVE ENDINGS) innervate target tissues and transduce noxious stimuli via axons to the CENTRAL NERVOUS SYSTEM.

Descriptor UI: D009619

Alternative terms: Nociceptors; Nociceptor; Pain Receptors; Pain Receptor; Receptors, Pain; Nociceptive Neurons; Neuron, Nociceptive; Neurons, Nociceptive; Nociceptive Neuron;

Allowable Qualifiers: classification; cytology; drug effects; enzymology; immunology; metabolism; microbiology; parasitology; pathology; physiology; radiation effects; radiography; radionuclide imaging; secretion; transplantation; ultrastructure; ultrasonography; chemistry; virology;

Tree Number: A08.663.650.915.875; A08.800.950.875; A11.671.650.915.875;

History Note: 78

Technical Notes: DF: NOCICEPT