Nucleoside-Phosphate Kinase - Chemistry
Research News and Information

Monday, November 23, 2009

Structure of the nucleotide radical formed during reaction of CDP/TTP with the E441Q-alpha2beta2 of E. coli ribonucleotide reductase.

12 Jan 2009 The Escherichia coli ribonucleotide reductase (RNR) catalyzes the conversion of nucleoside diphosphates to deoxynucleotides and requires a diferric-tyrosyl radical cofactor for catalysis. RNR is composed of a 1:1 complex of two homodimeric subunits: ... Read more...

Knowledge based identification of potent antitubercular compounds using structure based virtual screening and structure interaction fingerprints.

30 Dec 2008 In view of the worldwide spread of multidrug resistance of Mycobacterium tuberculosis, there is an urgent need to discover antitubercular agents with novel structures. Thymidine monophosphate kinase from M. tuberculosis (TMPKmt) is an attractive ... Read more...

Mutational, inhibitory and microcalorimetric analyses of Plasmodium falciparum TMP kinase. Implications for drug discovery.

30 Dec 2008 Plasmodium falciparum thymidylate kinase (PfTMK) can tolerate a range of substrates, which distinguishes it from other thymidylate kinases. The enzyme not only phosphorylates TMP and dUMP but can also tolerate bulkier purines, namely, dGMP, GMP, and ... Read more...

Latest indexed articles for 'Nucleoside-Phosphate Kinase - Chemistry'

These are the very latest articles for this heading:

• Structure of the nucleotide radical formed during reaction of CDP/TTP with the E441Q-alpha2beta2 of E. coli ribonucleotide reductase. 12 Jan 2009
• Knowledge based identification of potent antitubercular compounds using structure based virtual screening and structure interaction fingerprints. 30 Dec 2008
• Mutational, inhibitory and microcalorimetric analyses of Plasmodium falciparum TMP kinase. Implications for drug discovery. 30 Dec 2008
• A protein related to prokaryotic UMP kinases is involved in psaA/B transcript accumulation in Arabidopsis. 25 Nov 2008
• Unique GTP-binding pocket and allostery of uridylate kinase from a gram-negative phytopathogenic bacterium. 23 Nov 2008
• Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy. 27 Oct 2008
• Structural and functional characterization of Escherichia coli UMP kinase in complex with its allosteric regulator GTP. 20 Oct 2008
• The crystal structure of UMP kinase from Bacillus anthracis (BA1797) reveals an allosteric nucleotide-binding site. Jul 2008
• Restoration of the antiviral activity of 3'-azido-3'-deoxythymidine (AZT) against AZT-resistant human immunodeficiency virus by delivery of engineered thymidylate kinase to T cells. 29 Jun 2008
• Gemcitabine pharmacogenomics: deoxycytidine kinase and cytidylate kinase gene resequencing and functional genomics. 10 Jun 2008
• The influence of proline isomerization and off-pathway intermediates on the folding mechanism of eukaryotic UMP/CMP Kinase. 5 Jun 2008
• [Isolation, prokaryotic expression and activity analysis of thymidylate kinase (tmk) gene from Phytoplasma of wheat blue dwarf] 2 Jun 2008
• Molecular characterization, heterologous expression and kinetic analysis of recombinant Plasmodium falciparum thymidylate kinase. 11 May 2008
• Molecular basis for the lack of enantioselectivity of human 3-phosphoglycerate kinase. 5 May 2008
• Molecular modeling and dynamics studies of cytidylate kinase from Mycobacterium tuberculosis H37Rv. 13 Mar 2008
• Human uridine-cytidine kinase phosphorylation of ribavirin: a convenient method for activation of ribavirin for conjugation to proteins. 11 Dec 2007
• Structural and functional investigations of Ureaplasma parvum UMP kinase--a potential antibacterial drug target. 13 Nov 2007
• Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria. 11 Nov 2007
• Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth. 30 Sep 2007
• Enantioselectivity of human AMP, dTMP and UMP-CMP kinases. 8 Jul 2007

See a longer list of these articles.

Technical information about 'Nucleoside-Phosphate Kinase'

Definition: An enzyme that catalyzes reversible reactions of a nucleoside triphosphate, e.g., ATP, with a nucleoside monophosphate, e.g., UMP, to form ADP and UDP. Many nucleoside monophosphates can act as acceptor while many ribo- and deoxyribonucleoside triphosphates can act as donor. EC 2.7.4.4.

Chemical name: ATP:nucleoside-phosphate phosphotransferase

Registry Number: EC 2.7.4.4

Descriptor UI: D009703

Alternative terms: Nucleoside-Phosphate Kinase; Kinase, Nucleoside-Phosphate; Nucleoside Phosphate Kinase; Nucleoside Monophosphate Kinases; Kinases, Nucleoside Monophosphate; Monophosphate Kinases, Nucleoside;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.913.696.650.575;

Online Note: use NUCLEOSIDE-PHOSPHATE KINASE to search NUCLEOSIDE MONOPHOSPHATE KINASES 1977-93

History Note: 94; was NUCLEOSIDE MONOPHOSPHATE KINASES 1977-93 (see under PHOSPHOTRANSFERASES, ATP 1977-90)