Nucleoside-Phosphate Kinase
Research News and Information

Sunday, November 22, 2009

Functional analysis of pyrimidine biosynthesis enzymes using the anticancer drug 5-fluorouracil in Caenorhabditis elegans.

21 Jul 2009 Pyrimidine biosynthesis enzymes function in many cellular processes and are closely associated with pyrimidine antagonists used in cancer chemotherapy. These enzymes are well characterized from bacteria to mammals, but not in a simple metazoan. To ... Read more...

Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase.

21 Jul 2009 Vaccinia virus thymidylate kinase, although similar in sequence to human TMP kinase, has broader substrate specificity and phosphorylates (E)-5-(2-bromovinyl)-dUMP and dGMP. Modified guanines such as glyoxal-dG, 8-oxo-dG, O(6)-methyl-dG, ... Read more...

Gemcitabine-based chemogene therapy for pancreatic cancer using Ad-dCK::UMK GDEPT and TS/RR siRNA strategies.

29 Jun 2009 Gemcitabine is a first-line agent for advanced pancreatic cancer therapy. However, its efficacy is often limited by its poor intracellular metabolism and chemoresistance. To exert its antitumor activity, gemcitabine requires to be converted to its ... Read more...

Latest indexed articles for 'Nucleoside-Phosphate Kinase'

These are the very latest articles for this heading:

• Functional analysis of pyrimidine biosynthesis enzymes using the anticancer drug 5-fluorouracil in Caenorhabditis elegans. 21 Jul 2009
• Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase. 21 Jul 2009
• Gemcitabine-based chemogene therapy for pancreatic cancer using Ad-dCK::UMK GDEPT and TS/RR siRNA strategies. 29 Jun 2009
• The yeast Cdc8 exhibits both deoxythymidine monophosphate and diphosphate kinase activities. 16 Jun 2009
• Rational design and 3D-pharmacophore mapping of 5'-thiourea-substituted alpha-thymidine analogues as mycobacterial TMPK inhibitors. 30 Mar 2009
• Theoretical basis for reducing time-lines to the determination of positive Mycobacterium tuberculosis cultures using thymidylate kinase (TMK) assays. 16 Mar 2009
• Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins. 28 Feb 2009
• The Rv1712 Locus from Mycobacterium tuberculosis H37Rv codes for a functional CMP kinase that preferentially phosphorylates dCMP. 28 Jan 2009
• Structure of the nucleotide radical formed during reaction of CDP/TTP with the E441Q-alpha2beta2 of E. coli ribonucleotide reductase. 12 Jan 2009
• Enzymatic synthesis of TDP-deoxysugars. 30 Dec 2008
• Knowledge based identification of potent antitubercular compounds using structure based virtual screening and structure interaction fingerprints. 30 Dec 2008
• Mutational, inhibitory and microcalorimetric analyses of Plasmodium falciparum TMP kinase. Implications for drug discovery. 30 Dec 2008
• The site for the allosteric activator GTP of Escherichia coli UMP kinase. 7 Dec 2008
• A protein related to prokaryotic UMP kinases is involved in psaA/B transcript accumulation in Arabidopsis. 25 Nov 2008
• Unique GTP-binding pocket and allostery of uridylate kinase from a gram-negative phytopathogenic bacterium. 23 Nov 2008
• Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy. 27 Oct 2008
• Structural and functional characterization of Escherichia coli UMP kinase in complex with its allosteric regulator GTP. 20 Oct 2008
• Myristoylated adenylate kinase-2 of Plasmodium falciparum forms a heterodimer with myristoyltransferase. 6 Oct 2008
• Antiflagellin antibodies recognize the autoantigens Toll-Like Receptor 5 and Pals 1-associated tight junction protein and induce monocytes activation and increased intestinal permeability in Crohn's disease. 13 Sep 2008
• The crystal structure of UMP kinase from Bacillus anthracis (BA1797) reveals an allosteric nucleotide-binding site. Jul 2008

See a longer list of these articles.

Technical information about 'Nucleoside-Phosphate Kinase'

Definition: An enzyme that catalyzes reversible reactions of a nucleoside triphosphate, e.g., ATP, with a nucleoside monophosphate, e.g., UMP, to form ADP and UDP. Many nucleoside monophosphates can act as acceptor while many ribo- and deoxyribonucleoside triphosphates can act as donor. EC 2.7.4.4.

Chemical name: ATP:nucleoside-phosphate phosphotransferase

Registry Number: EC 2.7.4.4

Descriptor UI: D009703

Alternative terms: Nucleoside-Phosphate Kinase; Kinase, Nucleoside-Phosphate; Nucleoside Phosphate Kinase; Nucleoside Monophosphate Kinases; Kinases, Nucleoside Monophosphate; Monophosphate Kinases, Nucleoside;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.913.696.650.575;

Online Note: use NUCLEOSIDE-PHOSPHATE KINASE to search NUCLEOSIDE MONOPHOSPHATE KINASES 1977-93

History Note: 94; was NUCLEOSIDE MONOPHOSPHATE KINASES 1977-93 (see under PHOSPHOTRANSFERASES, ATP 1977-90)