Nucleus Accumbens - Drug effects
Research News and Information

Saturday, November 21, 2009

Selective serotonin receptor stimulation of the medial nucleus accumbens causes differential effects on food intake and locomotion.

29 Sep 2009 Substantial evidence suggests that pharmacological manipulations of neural serotonin pathways influence ingestive behaviors. Despite the known role of the nucleus accumbens in directing appetitive and consummatory behavior, there has been little ... Read more...

Regulation of dynamin 2 and G protein-coupled receptor kinase 2 in rat nucleus accumbens during acute and repeated cocaine administration.

29 Sep 2009 Exposure to cocaine causes many neuroadaptations including alterations in several neurotransmitter receptors and transporters. This study investigated potential mechanisms of cocaine-induced receptor and transporter regulation by measuring levels of ... Read more...

Similar neurons, opposite adaptations: psychostimulant experience differentially alters firing properties in accumbens core versus shell.

28 Sep 2009 The principal components of neuronal excitability include synaptic and intrinsic membrane parameters. While recent studies indicate that cocaine exposure can induce widespread changes in synaptic function in the neural circuits for reward, intrinsic ... Read more...

Latest indexed articles for 'Nucleus Accumbens - Drug effects'

These are the very latest articles for this heading:

• Selective serotonin receptor stimulation of the medial nucleus accumbens causes differential effects on food intake and locomotion. 29 Sep 2009
• Regulation of dynamin 2 and G protein-coupled receptor kinase 2 in rat nucleus accumbens during acute and repeated cocaine administration. 29 Sep 2009
• Similar neurons, opposite adaptations: psychostimulant experience differentially alters firing properties in accumbens core versus shell. 28 Sep 2009
• Antidepressant actions of histone deacetylase inhibitors. 14 Sep 2009
• Neural encoding of cocaine-seeking behavior is coincident with phasic dopamine release in the accumbens core and shell. 2 Sep 2009
• Dopaminergic response to graded dopamine concentration elicited by four amphetamine doses. 30 Aug 2009
• In vivo evidence that constitutive activity of serotonin2C receptors in the medial prefrontal cortex participates in the control of dopamine release in the rat nucleus accumbens: differential effects of inverse agonist versus antagonist. 20 Aug 2009
• Presynaptic action of neurotensin on dopamine release through inhibition of D(2) receptor function. 12 Aug 2009
• Nucleus accumbens neurons exhibit synaptic scaling that is occluded by repeated dopamine pre-exposure. 5 Aug 2009
• Behavioral characterization of amygdala involvement in mediating intra-accumbens opioid-driven feeding behavior. 30 Jul 2009
• Inactivating the activated: identifying functions of specific neural networks. 30 Jul 2009
• P2 receptor-mediated stimulation of the PI3-K/Akt-pathway in vivo. 30 Jul 2009
• Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbens. 27 Jul 2009
• Chronic ethanol treatment potentiates ethanol-induced increases in interstitial nucleus accumbens endocannabinoid levels in rats. 21 Jul 2009
• Upregulation of GLT1 attenuates cue-induced reinstatement of cocaine-seeking behavior in rats. 20 Jul 2009
• Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization. 18 Jul 2009
• In vivo cocaine experience generates silent synapses. 14 Jul 2009
• Antidepressant treatment facilitates dopamine release and drug seeking behavior in a genetic animal model of depression. 13 Jul 2009
• Distinct opioid circuits determine the palatability and the desirability of rewarding events. 11 Jul 2009
• Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. 11 Jul 2009

See a longer list of these articles.

Technical information about 'Nucleus Accumbens'

Definition: Collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the so-called ventral striatum, a composite structure considered part of the basal ganglia.

Descriptor UI: D009714

Alternative terms: Nucleus Accumbens; Accumbens, Nucleus;

Allowable Qualifiers: abnormalities; anatomy & histology; blood supply; cytology; drug effects; embryology; enzymology; growth & development; immunology; injuries; metabolism; microbiology; parasitology; pathology; physiology; physiopathology; radiation effects; radiography; radionuclide imaging; secretion; surgery; transplantation; ultrastructure; ultrasonography; chemistry; virology;

Tree Number: A08.186.211.730.885.287.249.683;

History Note: 91(78); was see under SEPTAL NUCLEI 1978-90