Oligonucleotides - Pharmacology
Research News and Information

Monday, November 23, 2009

Development of universal antidotes to control aptamer activity.

2 Oct 2009 With an ever increasing number of people taking numerous medications, the need to safely administer drugs and limit unintended side effects has never been greater. Antidote control remains the most direct means to counteract acute side effects of ... Read more...

Improved detection of chromosomal abnormalities in chronic lymphocytic leukemia by conventional cytogenetics using CpG oligonucleotide and interleukin-2 stimulation: A Belgian multicentric study.

29 Sep 2009 We performed a multicentric study to assess the impact of two different culture procedures on the detection of chromosomal abnormalities in 217 consecutive unselected cases with chronic lymphocytic leukemia (CLL) referred for routine analysis either ... Read more...

Complete regression of advanced primary and metastatic mouse melanomas following combination chemoimmunotherapy.

19 Jul 2009 The development of therapeutic strategies which induce effective cellular antitumor immunity represents an important goal in cancer immunology. Here, we used the unique features of the genetically engineered Hgf-Cdk4(R24C) mouse model to identify a ... Read more...

Latest indexed articles for 'Oligonucleotides - Pharmacology'

These are the very latest articles for this heading:

• Development of universal antidotes to control aptamer activity. 2 Oct 2009
• Improved detection of chromosomal abnormalities in chronic lymphocytic leukemia by conventional cytogenetics using CpG oligonucleotide and interleukin-2 stimulation: A Belgian multicentric study. 29 Sep 2009
• Complete regression of advanced primary and metastatic mouse melanomas following combination chemoimmunotherapy. 19 Jul 2009
• The phospho-dependent dynamin-syndapin interaction triggers activity-dependent bulk endocytosis of synaptic vesicles. 15 Jun 2009
• Modulation of TLR2 protein expression by miR-105 in human oral keratinocytes. 7 Jun 2009
• In-vitro evaluation of anti-factor IXa aptamer on thrombin generation, clotting time, and viscoelastometry. 29 Apr 2009
• Identification and characterization of oligonucleotides that inhibit Toll-like receptor 2-associated immune responses. 28 Apr 2009
• Inactivation of expression of several genes in a variety of bacterial species by EGS technology. 28 Apr 2009
• Hepatitis C virus single-stranded RNA induces innate immunity via Toll-like receptor 7. 15 Apr 2009
• Nitrogen excretion in developing zebrafish (Danio rerio): a role for Rh proteins and urea transporters. 9 Mar 2009
• The essential role of endogenous ghrelin in growth hormone expression during zebrafish adenohypophysis development. 3 Mar 2009
• A novel regulatory B-cell population in sheep Peyer's patches spontaneously secretes IL-10 and downregulates TLR9-induced IFNalpha responses. 2 Mar 2009
• Potent in vivo antiangiogenic effects of GS-101 (5'-TATCCGGAGGGCTCGCCATGCTGCT-3'), an antisense oligonucleotide preventing the expression of insulin receptor substrate-1. 8 Feb 2009
• Human microsatellite DNA mimicking oligodeoxynucleotides down-regulate TLR9-dependent and -independent activation of human immune cells. 5 Feb 2009
• HPMA polymer-based site-specific delivery of oligonucleotides to hepatic stellate cells. 30 Jan 2009
• Regulation of targeted gene repair by intrinsic cellular processes. 30 Jan 2009
• The strand transfer oligonucleotide inhibitors of HIV-integrase. 30 Jan 2009
• RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice. 19 Jan 2009
• Increased cytotoxicity of cisplatin in SK-MEL 28 melanoma cells upon down-regulation of melanoma inhibitor of apoptosis protein. 30 Dec 2008
• G-rich oligonucleotides for cancer treatment. 30 Dec 2008

See a longer list of these articles.

Technical information about 'Oligonucleotides'

Definition: Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)

Registry Number: 0

Descriptor UI: D009841

Alternative terms: Oligonucleotides;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D13.695.578.424;

History Note: 74(72)

Technical Notes: 2-12 nucleotides