Oligonucleotides, Antisense - Pharmacology
Research News and Information

Sunday, November 22, 2009

Characterization of small RNAs in aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB.

22 Sep 2009 Memory storage and memory-related synaptic plasticity rely on precise spatiotemporal regulation of gene expression. To explore the role of small regulatory RNAs in learning-related synaptic plasticity, we carried out massive parallel sequencing to ... Read more...

Specific inhibition of epithelial Na+ channels by antisense oligonucleotides for the treatment of Na+ hyperabsorption in cystic fibrosis.

30 Aug 2009 BACKGROUND: Cystic fibrosis (CF) respiratory epithelia are characterized by a defect Cl(-) secretion and an increased Na(+) absorption through epithelial Na(+) channels (ENaC). The present study aimed to find an effective inhibitor of human ENaC ... Read more...

Organizer restriction through modulation of Bozozok stability by the E3 ubiquitin ligase Lnx-like.

7 Aug 2009 The organizer anchors the primary embryonic axis, and balance between dorsal (organizer) and ventral domains is fundamental to body patterning. LNX (ligand of Numb protein-X) is a RING finger and four PDZ domain-containing E3 ubiquitin ligase. LNX ... Read more...

Latest indexed articles for 'Oligonucleotides, Antisense - Pharmacology'

These are the very latest articles for this heading:

• Characterization of small RNAs in aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB. 22 Sep 2009
• Specific inhibition of epithelial Na+ channels by antisense oligonucleotides for the treatment of Na+ hyperabsorption in cystic fibrosis. 30 Aug 2009
• Organizer restriction through modulation of Bozozok stability by the E3 ubiquitin ligase Lnx-like. 7 Aug 2009
• Mechanistic study on growth suppression and apoptosis induction by targeting hepatoma-derived growth factor in human hepatocellular carcinoma HepG2 cells. Aug 2009
• Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids. 30 Jul 2009
• In vivo silencing of the Ca(V)3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy. Jul 2009
• Regulation of the cell cycle gene, BTG2, by miR-21 in human laryngeal carcinoma. 29 Jun 2009
• Disc1 regulates foxd3 and sox10 expression, affecting neural crest migration and differentiation. 29 Jun 2009
• SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. 20 Jun 2009
• Oligonucleotide-mediated survival of motor neuron protein expression in CNS improves phenotype in a mouse model of spinal muscular atrophy. 15 Jun 2009
• Delineating bacteriostatic and bactericidal targets in mycobacteria using IPTG inducible antisense expression. 13 Jun 2009
• Lipopolysaccharide-induced inflammatory cytokine production by Schwann's cells dependent upon TLR4 expression. 11 Jun 2009
• MiR-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor. 7 Jun 2009
• Inhibition of ataxia-telangiectasia mutated by antisense oligonucleotide nanoparticles induces radiosensitization of head and neck squamous-cell carcinoma in mice. 30 May 2009
• TTLL3 Is a tubulin glycine ligase that regulates the assembly of cilia. 30 May 2009
• Spleen-specific suppression of TNF-alpha by cationic hydrogel-delivered antisense nucleotides for the prevention of arthritis in animal models. 26 May 2009
• Tumor necrosis factor-receptor-associated factor-4 is a positive regulator of transforming growth factor-beta signaling that affects neural crest formation. 18 May 2009
• A multi-target antisense approach against PDE4 and PDE7 reduces smoke-induced lung inflammation in mice. 18 May 2009
• Gnao1 (G alphaO protein) is a likely genetic contributor to variation in physical dependence on opioids in mice. 17 May 2009
• Syntaxin modulates Kv1.1 through dual action on channel surface expression and conductance. 17 May 2009

See a longer list of these articles.

Technical information about 'Oligonucleotides, Antisense'

Definition: Short fragments of DNA or RNA that are used to alter the function of target RNAs or DNAs to which they hybridize.

Registry Number: 0

Descriptor UI: D016376

Alternative terms: Oligonucleotides, Antisense; Anti-Sense Oligonucleotides; Anti Sense Oligonucleotides; Oligonucleotides, Anti-Sense; Antisense Oligonucleotides;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D13.150.480; D13.444.600.150.640; D13.695.578.424.480; D27.720.470.530.600.150.640;

History Note: 91

Technical Notes: coord IM with THIONUCLEOTIDES (IM or NIM if pertinent)