Oligonucleotides, Antisense
Research News and Information

Sunday, November 22, 2009

Mitochondrial dysfunction increases allergic airway inflammation.

26 Sep 2009 The prevalence of allergies and asthma among the world's population has been steadily increasing due to environmental factors. It has been described that exposure to ozone, diesel exhaust particles, or tobacco smoke exacerbates allergic inflammation ... Read more...

Characterization of small RNAs in aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB.

22 Sep 2009 Memory storage and memory-related synaptic plasticity rely on precise spatiotemporal regulation of gene expression. To explore the role of small regulatory RNAs in learning-related synaptic plasticity, we carried out massive parallel sequencing to ... Read more...

Specific inhibition of epithelial Na+ channels by antisense oligonucleotides for the treatment of Na+ hyperabsorption in cystic fibrosis.

30 Aug 2009 BACKGROUND: Cystic fibrosis (CF) respiratory epithelia are characterized by a defect Cl(-) secretion and an increased Na(+) absorption through epithelial Na(+) channels (ENaC). The present study aimed to find an effective inhibitor of human ENaC ... Read more...

Latest indexed articles for 'Oligonucleotides, Antisense'

These are the very latest articles for this heading:

• Mitochondrial dysfunction increases allergic airway inflammation. 26 Sep 2009
• Characterization of small RNAs in aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB. 22 Sep 2009
• Specific inhibition of epithelial Na+ channels by antisense oligonucleotides for the treatment of Na+ hyperabsorption in cystic fibrosis. 30 Aug 2009
• Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia. 30 Aug 2009
• Development of antisense-mediated exon skipping as a treatment for duchenne muscular dystrophy. 30 Aug 2009
• p75 neurotrophin receptor is implicated in the ability of neurotrophin-3 to negatively modulate activated ERK1/2 signaling in TrkA-expressing adult sensory neurons. 30 Aug 2009
• Ca(v)1.2 splice variant with exon 9* is critical for regulation of cerebral artery diameter. 26 Aug 2009
• Slow formation of a pseudoknot structure is rate limiting in the productive co-transcriptional folding of the self-splicing Candida intron. 24 Aug 2009
• Less is more: therapeutic exon skipping for Duchenne muscular dystrophy. 23 Aug 2009
• Kinetic optimization of a protein-responsive aptamer beacon. 13 Aug 2009
• Triplet-repeat oligonucleotide-mediated reversal of RNA toxicity in myotonic dystrophy. 8 Aug 2009
• Organizer restriction through modulation of Bozozok stability by the E3 ubiquitin ligase Lnx-like. 7 Aug 2009
• Mechanistic study on growth suppression and apoptosis induction by targeting hepatoma-derived growth factor in human hepatocellular carcinoma HepG2 cells. Aug 2009
• [Mutation-specific treatments for Duchenne muscular dystrophy] 30 Jul 2009
• Nkcc1 (Slc12a2) is required for the regulation of endolymph volume in the otic vesicle and swim bladder volume in the zebrafish larva. 30 Jul 2009
• PAR-1 phosphorylates Mind bomb to promote vertebrate neurogenesis. 30 Jul 2009
• Antisense inhibitors, ribozymes, and siRNAs. 30 Jul 2009
• Oral delivery of siRNA and antisense oligonucleotides. 30 Jul 2009
• Ginkgolide B induces apoptosis via activation of JNK and p21-activated protein kinase 2 in mouse embryonic stem cells. 30 Jul 2009
• Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Oligonucleotides, Antisense'

Definition: Short fragments of DNA or RNA that are used to alter the function of target RNAs or DNAs to which they hybridize.

Registry Number: 0

Descriptor UI: D016376

Alternative terms: Oligonucleotides, Antisense; Anti-Sense Oligonucleotides; Anti Sense Oligonucleotides; Oligonucleotides, Anti-Sense; Antisense Oligonucleotides;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D13.150.480; D13.444.600.150.640; D13.695.578.424.480; D27.720.470.530.600.150.640;

History Note: 91

Technical Notes: coord IM with THIONUCLEOTIDES (IM or NIM if pertinent)