Oligonucleotides
Research News and Information

Monday, November 23, 2009

Development of universal antidotes to control aptamer activity.

2 Oct 2009 With an ever increasing number of people taking numerous medications, the need to safely administer drugs and limit unintended side effects has never been greater. Antidote control remains the most direct means to counteract acute side effects of ... Read more...

Improved detection of chromosomal abnormalities in chronic lymphocytic leukemia by conventional cytogenetics using CpG oligonucleotide and interleukin-2 stimulation: A Belgian multicentric study.

29 Sep 2009 We performed a multicentric study to assess the impact of two different culture procedures on the detection of chromosomal abnormalities in 217 consecutive unselected cases with chronic lymphocytic leukemia (CLL) referred for routine analysis either ... Read more...

Fluorescence of unmodified oligonucleotides: A tool to probe G-quadruplex DNA structure.

29 Sep 2009 Fluorescence of unmodified oligonucleotides has not been exploited for guanine-quadruplex (G-quadruplex) characterization. We observe that G-rich sequences fluoresce more strongly than duplex or single-stranded DNA but much more weakly than ... Read more...

Latest indexed articles for 'Oligonucleotides'

These are the very latest articles for this heading:

• Development of universal antidotes to control aptamer activity. 2 Oct 2009
• Improved detection of chromosomal abnormalities in chronic lymphocytic leukemia by conventional cytogenetics using CpG oligonucleotide and interleukin-2 stimulation: A Belgian multicentric study. 29 Sep 2009
• Fluorescence of unmodified oligonucleotides: A tool to probe G-quadruplex DNA structure. 29 Sep 2009
• Quadruple 9-mer-based protein binding microarray with DsRed fusion protein. 16 Sep 2009
• MMR/c-Abl-dependent activation of ING2/p73alpha signaling regulates the cell death response to N-methyl-N'-nitro-N-nitrosoguanidine. 15 Sep 2009
• A simple ligand that selectively targets CUG trinucleotide repeats and inhibits MBNL protein binding. 6 Sep 2009
• Comparison of the thermodynamics and base-pair dynamics of a full LNA:DNA duplex and of the isosequential DNA:DNA duplex. 6 Sep 2009
• Cu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition reaction in nucleoside, nucleotide, and oligonucleotide chemistry. 30 Aug 2009
• Sensitive and visual detection of adenosine by a rationally designed FokI-based biosensing strategy. 30 Aug 2009
• Proceedings of the 4th Annual Conference of the Oligonucleotide Therapeutics Society, October 15-18, 2008, Boston, Massachusetts, USA. 30 Aug 2009
• Peptide-morpholino conjugate: a promising therapeutic for Duchenne muscular dystrophy. 30 Aug 2009
• Allele-selective inhibition of mutant huntingtin by peptide nucleic acid-peptide conjugates, locked nucleic acid, and small interfering RNA. 30 Aug 2009
• New developments of the various classes of oligonucleotides. Preface. 30 Aug 2009
• Heat-activatable primers for hot-start PCR: oligonucleotide synthesis and basic PCR setup. 30 Aug 2009
• Improved gap-repair cloning method that uses oligonucleotides to target cognate sequences. 30 Aug 2009
• Association of insulin-like growth factor 2 with the insulin-linked polymorphic region in cultured fetal thymus cells. 30 Aug 2009
• Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study. 23 Aug 2009
• Agarose-assisted dip-pen nanolithography of oligonucleotides and proteins. 23 Aug 2009
• 50 nm DNA nanoarrays generated from uniform oligonucleotide films. 23 Aug 2009
• The sensitive and selective optical detection of mercury(II) ions by using a phosphorothioate DNAzyme strategy. 15 Aug 2009

See a longer list of these articles.

Technical information about 'Oligonucleotides'

Definition: Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)

Registry Number: 0

Descriptor UI: D009841

Alternative terms: Oligonucleotides;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D13.695.578.424;

History Note: 74(72)

Technical Notes: 2-12 nucleotides