Osteoblasts - Metabolism
Research News and Information

Saturday, November 21, 2009

Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfbeta in osteosarcoma cells.

29 Nov 2009 Bone formation and osteoblast differentiation require the functional expression of the Runx2/Cbfbeta heterodimeric transcription factor complex. Runx2 is also a suppressor of proliferation in osteoblasts by attenuating cell cycle progression in ... Read more...

Osteoblast differentiation is functionally associated with decreased AMP kinase activity.

29 Nov 2009 Osteoblasts, originating from mesenchymal stem cells, play a pivotal role in bone formation and mineralization. Several transcription factors including runt-related transcription factor 2 (Runx2) have been reported to be essential for osteoblast ... Read more...

Membrane-dependent bystander effect contributes to amplification of the response to alpha-particle irradiation in targeted and nontargeted cells.

13 Nov 2009 PURPOSE: Free radicals are believed to play an active role in the bystander response. This study investigated their origin as well as their temporal and spatial impacts in the bystander effect. METHODS AND MATERIALS: We employed a precise ... Read more...

Latest indexed articles for 'Osteoblasts - Metabolism'

These are the very latest articles for this heading:

• Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfbeta in osteosarcoma cells. 29 Nov 2009
• Osteoblast differentiation is functionally associated with decreased AMP kinase activity. 29 Nov 2009
• Membrane-dependent bystander effect contributes to amplification of the response to alpha-particle irradiation in targeted and nontargeted cells. 13 Nov 2009
• Runx2 and bone morphogenic protein 2 regulate the expression of an alternative Lef1 transcript during osteoblast maturation. 30 Oct 2009
• Phosphatidylinositol 3 kinase/Akt signal relay cooperates with smad in bone morphogenetic protein-2-induced colony stimulating factor-1 (CSF-1) expression and osteoclast differentiation. 7 Oct 2009
• Colony-stimulating factor-1 (CSF-1) directly inhibits receptor activator of nuclear factor-{kappa}B ligand (RANKL) expression by osteoblasts. 7 Oct 2009
• Bone formation regulates circulating concentrations of fibroblast growth factor 23. 7 Oct 2009
• Mitochondrial bioenergetics and distribution in living human osteoblasts grown on implant surfaces. 29 Sep 2009
• Increased osteoblast functions in the presence of BMP-7 short peptides for nanostructured biomaterial applications. 29 Sep 2009
• Cocultures of osteoblasts and osteoclasts are influenced by local application of zoledronic acid incorporated in a poly(D,L-lactide) implant coating. 29 Sep 2009
• Mixing conditions for cell scaffolds affect the bone formation induced by bone engineering with human bone marrow stromal cells, beta-tricalcium phosphate granules, and rhBMP-2. 29 Sep 2009
• Osteoblast activity on collagen-GAG scaffolds is affected by collagen and GAG concentrations. 29 Sep 2009
• Flow perfusion culture of human fetal bone cells in large beta-tricalcium phosphate scaffold with controlled architecture. 29 Sep 2009
• Novel carbon fiber composite for hip replacement with improved in vitro and in vivo osseointegration. 29 Sep 2009
• Pulsating fluid flow modulates gene expression of proteins involved in Wnt signaling pathways in osteocytes. 29 Sep 2009
• cAMP activation by PACAP/VIP stimulates IL-6 release and inhibits osteoblastic differentiation through VPAC2 receptor in osteoblastic MC3T3 cells. 29 Sep 2009
• CCL20/CCR6 chemokine/receptor expression in bone tissue from osteoarthritis and rheumatoid arthritis patients: different response of osteoblasts in the two groups. 29 Sep 2009
• Development of biodegradable and injectable macromers based on poly(ethylene glycol) and diacid monomers. 13 Sep 2009
• Asporin competes with decorin for collagen binding, binds calcium and promotes osteoblast collagen mineralization. 12 Sep 2009
• Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transition. 9 Sep 2009

See a longer list of these articles.

Technical information about 'Osteoblasts'

Definition: Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.

Descriptor UI: D010006

Alternative terms: Osteoblasts; Osteoblast;

Related Mesh Headings: Osteoclasts;

Allowable Qualifiers: classification; cytology; drug effects; enzymology; immunology; metabolism; microbiology; parasitology; pathology; physiology; radiation effects; radiography; radionuclide imaging; secretion; transplantation; ultrastructure; ultrasonography; chemistry; virology;

Tree Number: A11.329.629;

History Note: 65(64)