Osteoblasts
Research News and Information

Saturday, November 21, 2009

Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation in a new pre-chemotherapeutic osteosarcoma cell line (OS1).

29 Nov 2009 Osteosarcomas are the most prevalent primary bone tumors found in pediatric patients. To understand their molecular etiology, cell culture models are used to define disease mechanisms under controlled conditions. Many osteosarcoma cell lines (e.g., ... Read more...

Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfbeta in osteosarcoma cells.

29 Nov 2009 Bone formation and osteoblast differentiation require the functional expression of the Runx2/Cbfbeta heterodimeric transcription factor complex. Runx2 is also a suppressor of proliferation in osteoblasts by attenuating cell cycle progression in ... Read more...

Osteoblast differentiation is functionally associated with decreased AMP kinase activity.

29 Nov 2009 Osteoblasts, originating from mesenchymal stem cells, play a pivotal role in bone formation and mineralization. Several transcription factors including runt-related transcription factor 2 (Runx2) have been reported to be essential for osteoblast ... Read more...

Latest indexed articles for 'Osteoblasts'

These are the very latest articles for this heading:

• Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation in a new pre-chemotherapeutic osteosarcoma cell line (OS1). 29 Nov 2009
• Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfbeta in osteosarcoma cells. 29 Nov 2009
• Osteoblast differentiation is functionally associated with decreased AMP kinase activity. 29 Nov 2009
• Membrane-dependent bystander effect contributes to amplification of the response to alpha-particle irradiation in targeted and nontargeted cells. 13 Nov 2009
• Novel hypotheses in the etiopathogenesis of bisphosphonate-related osteonecrosis of the jaws. 30 Oct 2009
• Effect of ibuprofen on osteoblast differentiation of porcine bone marrow-derived progenitor cells. 30 Oct 2009
• Osterix enhances BMSC-associated osseointegration of implants. 30 Oct 2009
• Runx2 and bone morphogenic protein 2 regulate the expression of an alternative Lef1 transcript during osteoblast maturation. 30 Oct 2009
• Phosphatidylinositol 3 kinase/Akt signal relay cooperates with smad in bone morphogenetic protein-2-induced colony stimulating factor-1 (CSF-1) expression and osteoclast differentiation. 7 Oct 2009
• Colony-stimulating factor-1 (CSF-1) directly inhibits receptor activator of nuclear factor-{kappa}B ligand (RANKL) expression by osteoblasts. 7 Oct 2009
• Bone formation regulates circulating concentrations of fibroblast growth factor 23. 7 Oct 2009
• Mitochondrial bioenergetics and distribution in living human osteoblasts grown on implant surfaces. 29 Sep 2009
• Micro-organism and cell viability on antimicrobially modified titanium. 29 Sep 2009
• Runx2, osx, and dspp in tooth development. 29 Sep 2009
• Increased osteoblast functions in the presence of BMP-7 short peptides for nanostructured biomaterial applications. 29 Sep 2009
• Cocultures of osteoblasts and osteoclasts are influenced by local application of zoledronic acid incorporated in a poly(D,L-lactide) implant coating. 29 Sep 2009
• Interactions with nanoscale topography: adhesion quantification and signal transduction in cells of osteogenic and multipotent lineage. 29 Sep 2009
• Mixing conditions for cell scaffolds affect the bone formation induced by bone engineering with human bone marrow stromal cells, beta-tricalcium phosphate granules, and rhBMP-2. 29 Sep 2009
• Osteoblast activity on collagen-GAG scaffolds is affected by collagen and GAG concentrations. 29 Sep 2009
• Flow perfusion culture of human fetal bone cells in large beta-tricalcium phosphate scaffold with controlled architecture. 29 Sep 2009

See a longer list of these articles.

Technical information about 'Osteoblasts'

Definition: Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.

Descriptor UI: D010006

Alternative terms: Osteoblasts; Osteoblast;

Related Mesh Headings: Osteoclasts;

Allowable Qualifiers: classification; cytology; drug effects; enzymology; immunology; metabolism; microbiology; parasitology; pathology; physiology; radiation effects; radiography; radionuclide imaging; secretion; transplantation; ultrastructure; ultrasonography; chemistry; virology;

Tree Number: A11.329.629;

History Note: 65(64)