 |
Oxidants - Pharmacology
Research News and Information
Definition of 'Oxidants'Oxidizing agents or electron-accepting molecules in chemical reactions in which electrons are transferred from one molecule to another (OXIDATION-REDUCTION). In vivo, it appears that phagocyte-generated oxidants function as tumor promoters or cocarcinogens rather than as complete carcinogens perhaps because of the high levels of endogenous antioxidant defenses. It is also thought that oxidative damage in joints may trigger the autoimmune response that characterizes the persistence of the rheumatoid disease process. |
Sunday, November 22, 2009
12 Oct 2009 
In Alzheimer's disease (AD), rod-like cofilin aggregates (cofilin-actin rods) and thread-like inclusions containing phosphorylated microtubule-associated protein (pMAP) tau form in the brain (neuropil threads), and the extent of their presence ... Read more...
Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress.
29 Sep 2009 The enhanced oxidative stress associated with type 2 diabetes mellitus contributes to disease pathogenesis. We previously identified plasma membrane-associated ATP-sensitive K+ (KATP) channels of pancreatic beta cells as targets for oxidants. Here, ... Read more...
29 Sep 2009 PURPOSE: To study the effect of hydrogen peroxide (H(2)O(2)) on radiation-induced apoptosis in human prostate cancer PC-3 cells. METHODS AND MATERIALS: At 4h before the irradiation, PC-3 cells were exposed to 10mM ammonium chloride (NH(4)Cl) ... Read more...
Latest indexed articles for 'Oxidants - Pharmacology'
These are the very latest articles for this heading:
- Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations. 12 Oct 2009
- Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress. 29 Sep 2009
- Combination treatment of hydrogen peroxide and X-rays induces apoptosis in human prostate cancer PC-3 cells. 29 Sep 2009
- In vitro translocation of quantum dots and influence of oxidative stress. 2 Sep 2009
- The OsDHODH1 gene is involved in salt and drought tolerance in rice. 30 Aug 2009
- Glutathionylation of p65NF-kappaB correlates with proliferating/apoptotic hepatoma cells exposed to pro- and anti-oxidants. 30 Aug 2009
- Protein phosphatase 5 protects neurons against amyloid-beta toxicity. 15 Aug 2009
- Generation of oxidant response to copper and iron nanoparticles and salts: Stimulation by ascorbate. 12 Aug 2009
- Cytoprotective effect of polypeptide from Chlamys farreri on neuroblastoma (SH-SY5Y) cells following HO exposure involves scavenging ROS and inhibition JNK phosphorylation. Aug 2009
- Hydrogen peroxide induces the activation of the phospholipase C-gamma1 survival pathway in PC12 cells: protective role in apoptosis. 30 Jul 2009
- Subapoptogenic oxidative stress strongly increases the activity of the glycolytic key enzyme glyceraldehyde 3-phosphate dehydrogenase. 30 Jul 2009
- Effects of cotreatment of 12-O-tetradecanoylphorbol-13-acetate and H2O2 on apoptotic regulation via AMP-activated protein kinase-cyclooxygenase-2 signals. 30 Jul 2009
- Multiple mechanisms for hydrogen peroxide-induced apoptosis. 30 Jul 2009
- Green tea catechin controls apoptosis in colon cancer cells by attenuation of H2O2-stimulated COX-2 expression via the AMPK signaling pathway at low-dose H2O2. 30 Jul 2009
- Gallic acid induces neuronal cell death through activation of c-Jun N-terminal kinase and downregulation of Bcl-2. 30 Jul 2009
- Intracellular prooxidant activity of melatonin induces a survival pathway involving NF-kappaB activation. 30 Jul 2009
- Antioxidant and apoptotic effects of korean white ginseng extracted with the same ratio of protopanaxadiol and protopanaxatriol saponins in human hepatoma HepG2 cells. 30 Jul 2009
- Down syndrome critical region 1 enhances the proteolytic cleavage of calcineurin.
29 Jul 2009 - DNA-mediated redox signaling for transcriptional activation of SoxR. 25 Jul 2009
- P-glycoprotein expression in immortalised rat brain endothelial cells: comparisons following exogenously applied hydrogen peroxide and after hypoxia-reoxygenation. 23 Jul 2009
See a longer list of these articles.
Technical information about 'Oxidants'
Definition: Oxidizing agents or electron-accepting molecules in chemical reactions in which electrons are transferred from one molecule to another (OXIDATION-REDUCTION). In vivo, it appears that phagocyte-generated oxidants function as tumor promoters or cocarcinogens rather than as complete carcinogens perhaps because of the high levels of endogenous antioxidant defenses. It is also thought that oxidative damage in joints may trigger the autoimmune response that characterizes the persistence of the rheumatoid disease process.
Registry Number: 0
Descriptor UI: D016877
Alternative terms: Oxidants; Oxidizing Agents; Agents, Oxidizing;
Related Mesh Headings: Antioxidants;
Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists; biosynthesis; physiology;
Tree Number: D27.720.642; D27.888.569.540;
History Note: 92
Technical Notes: /biosyn /physiol permitted