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Oxidative Stress - Physiology
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Definition of 'Oxidative Stress'

A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).

Common names: Oxidative Stress; Oxidative Stresses; Stresses, Oxidative; Stress, Oxidative

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Saturday, November 21, 2009

Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation.

2 Nov 2009 The goal of this study was to elucidate the mechanisms of 17beta-estradiol (E(2)) antioxidant and neuroprotective actions in stroke. The results reveal a novel extranuclear receptor-mediated antioxidant mechanism for E(2) during stroke, as well as a ... Read more...


Oxidative stress disrupts oligodendrocyte maturation.

30 Oct 2009 Periventricular white matter injury (PWMI) is the leading cause of chronic neurologic injury among survivors of preterm birth. The hallmark of PWMI is hypomyelination and a lack of mature, myelinating oligodendrocytes. Oligodendrocytes undergo a ... Read more...


Hypoxia, not the frequency of sleep apnea, induces acute hemodynamic stress in patients with chronic heart failure.

25 Oct 2009 OBJECTIVES: This study was conducted to evaluate whether brain (B-type) natriuretic peptide (BNP) changes during sleep are associated with the frequency and severity of apneic/hypopneic episodes, intermittent arousals, and hypoxia. BACKGROUND: Sleep ... Read more...

 

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Technical information about 'Oxidative Stress'

Definition: A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).

Descriptor UI: D018384

Alternative terms: Oxidative Stress; Oxidative Stresses; Stresses, Oxidative; Stress, Oxidative;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: G03.495.710; G07.700.830.750;

History Note: 95

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