Oxotremorine - Pharmacology
Research News and Information

Tuesday, March 16, 2010

Reliable neuromodulation from circuits with variable underlying structure.

22 Jun 2009 Recent work argues that similar network performance can result from highly variable sets of network parameters, raising the question of whether neuromodulation can be reliable across individuals with networks with different sets of synaptic ... Read more...

Exploring the mechanism of agonist efficacy: a relationship between efficacy and agonist dissociation rate at the muscarinic M3 receptor.

2 Jun 2009 Although there are several empirical approaches that enable the comparison of relative agonist efficacy, the molecular basis that underlies differences in the ability of G protein-coupled receptor agonists to elicit a response is still largely ... Read more...

GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization.

26 May 2009 G protein-coupled receptor kinase 5 (GRK5) deficiency has been linked recently to early Alzheimer disease (AD), but the mechanism by which GRK5 deficiency may contribute to AD pathogenesis remains elusive. Here we report that overexpression of ... Read more...

Latest indexed articles for 'Oxotremorine - Pharmacology'

These are the very latest articles for this heading:

• Reliable neuromodulation from circuits with variable underlying structure. 22 Jun 2009
• Exploring the mechanism of agonist efficacy: a relationship between efficacy and agonist dissociation rate at the muscarinic M3 receptor. 2 Jun 2009
• GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization. 26 May 2009
• Effects of cholinesterase inhibition in supraspinal and spinal neural pathways on the micturition reflex in rats. 28 Mar 2009
• Preconditioning stimuli that augment chromaffin cell secretion. 9 Feb 2009
• Muscarinic inhibition of hippocampal and striatal adenylyl cyclase is mainly due to the M(4) receptor. 2 Feb 2009
• An optical dynamic mass redistribution assay reveals biased signaling of dualsteric GPCR activators. 30 Dec 2008
• Galantamine improves apomorphine-induced deficits in prepulse inhibition via muscarinic ACh receptors in mice. 30 Dec 2008
• Signaling mechanisms mediating muscarinic enhancement of GABAergic synaptic transmission in the spinal cord. 5 Dec 2008
• The muscarinic inhibition of the potassium M-current modulates the action-potential discharge in the vestibular primary-afferent neurons of the rat. 19 Nov 2008
• The glutamatergic nature of TRPV1-expressing neurons in the spinal dorsal horn. 17 Nov 2008
• Neurotransmitter responsiveness during early maturation of neural progenitor cells. 16 Nov 2008
• Nucleus accumbens acetylcholine and food intake: decreased muscarinic tone reduces feeding but not food-seeking. 9 Nov 2008
• Acetylcholine activity in selective striatal regions supports behavioral flexibility. 24 Oct 2008
• Activation of the protein p7OS6K via ERK phosphorylation by cholinergic muscarinic receptors stimulation in human neuroblastoma cells and in mice brain. 31 Aug 2008
• Formation and function of ceramide-enriched membrane platforms with CD38 during M1-receptor stimulation in bovine coronary arterial myocytes. 20 Aug 2008
• Antipsychotic property of a muscarinic receptor agonist in animal models for schizophrenia. 30 Jun 2008
• Methylphenidate-induced increases in vesicular dopamine sequestration and dopamine release in the striatum: the role of muscarinic and dopamine D2 receptors. 28 Jun 2008
• Cellular and synaptic actions of acetylcholine in the lamprey spinal cord. 9 Jun 2008
• Cholinergic modulation of neural activity in the telencephalon of the zebrafish. 21 Apr 2008

See a longer list of these articles.

Technical information about 'Oxotremorine'

Definition: A non-hydrolyzed muscarinic agonist used as a research tool.

Chemical name: 2-Pyrrolidinone, 1-(4-(1-pyrrolidinyl)-2-butynyl)-

Registry Number: 70-22-4

Descriptor UI: D010095

Alternative terms: Oxotremorine; Oxytremorine;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Muscarinic Agonists;

Tree Number: D03.383.773.812.498;

History Note: 73(72)

Technical Notes: a muscarinic agonist used in exper