p-Chloroamphetamine - Toxicity
Research News and Information

Sunday, November 22, 2009

Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation.

10 Jun 2008 Increased serotonin (5-hydroxytryptamine, 5-HT) release in the hippocampus induced by repeated stress is thought to be critical for the neuroadaptation that alleviates the adverse effects of stressors on emotion and behavior. A failure in this ... Read more...

Serotonergic and noradrenergic lesions suppress the enhancing effect of maternal exercise during pregnancy on learning and memory in rat pups.

15 Nov 2007 The beneficial effects of exercise on learning and memory are well documented but the effects of prenatal exposure to maternal exercise on offspring are not clear yet. Using a two-trial-per-day Morris water maze for five consecutive days, succeeded ... Read more...

The effects of p-chloroamphetamine, methamphetamine and 3,4-methylenedioxymethamphetamine (ecstasy) on the gene expression of cytoskeletal proteins in the rat brain.

27 Feb 2007 Repeated administration of beta-phenylalkylamines is known to produce neuronal changes in the central and peripheral nervous systems of mammals. It is suggested that various components of the cytoskeleton undergo profound alterations after ... Read more...

Latest indexed articles for 'p-Chloroamphetamine - Toxicity'

These are the very latest articles for this heading:

• Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation. 10 Jun 2008
• Serotonergic and noradrenergic lesions suppress the enhancing effect of maternal exercise during pregnancy on learning and memory in rat pups. 15 Nov 2007
• The effects of p-chloroamphetamine, methamphetamine and 3,4-methylenedioxymethamphetamine (ecstasy) on the gene expression of cytoskeletal proteins in the rat brain. 27 Feb 2007
• The acute and long-term neurotoxic effects of MDMA on marble burying behaviour in mice. 27 Feb 2006
• Loss of serotonin transporter protein after MDMA and other ring-substituted amphetamines. 23 Jan 2006
• Rat brain serotonin neurones that express neuronal nitric oxide synthase have increased sensitivity to the substituted amphetamine serotonin toxins 3,4-methylenedioxymethamphetamine and p-chloroamphetamine. 30 Dec 2004
• Endogenously released 5-hydroxytryptamine depresses the spinal monosynaptic reflex via 5-HT1D receptors. 23 Oct 2004
• Increased behavioural activity of rats in forced swimming test after partial denervation of serotonergic system by parachloroamphetamine treatment. 29 Sep 2004
• Long-lasting behavioral sensitization to psychostimulants following p-chloroamphetamine-induced neurotoxicity in mice. 30 Dec 2003
• High-dose fenfluramine administration decreases serotonin transporter binding, but not serotonin transporter protein levels, in rat forebrain. 29 Nov 2003
• p-Methylthioamphetamine and 1-(m-chlorophenyl)piperazine, two non-neurotoxic 5-HT releasers in vivo, differ from neurotoxic amphetamine derivatives in their mode of action at 5-HT nerve endings in vitro. 30 Aug 2002
• Acute melatonin and para-chloroamphetamine interactions on pineal, brain and serum serotonin levels as well as stress hormone levels. Aug 2001
• Novel radiotracers for imaging the serotonin transporter by positron emission tomography: synthesis, radiosynthesis, and in vitro and ex vivo evaluation of (11)C-labeled 2-(phenylthio)araalkylamines. 8 Aug 2000
• Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. 28 Feb 2000
• BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain. 13 Jan 2000
• Radix Angelica Sinensis extracts ameliorate scopolamine- and cycloheximide-induced amnesia, but not p-chloroamphetamine-induced amnesia in rats. 30 Dec 1999
• Effects of serotonin depletion by p-chlorophenylalanine, p-chloroamphetamine or 5,7-dihydroxytryptamine on central dopaminergic neurons: focus on tuberoinfundibular dopaminergic neurons and serum prolactin. 29 Apr 1999
• In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine. 29 Jun 1997
• Lack of neuroprotective effect of sigma receptor ligands in the neurotoxicity of p-chloroamphetamine in rat brain. 29 Oct 1996
• Studies on the mechanism of p-chloroamphetamine neurotoxicity. 23 Oct 1996

See a longer list of these articles.

Technical information about 'p-Chloroamphetamine'

Definition: Chlorinated analog of AMPHETAMINE. Potent neurotoxin that causes release and eventually depletion of serotonin in the CNS. It is used as a research tool.

Chemical name: Benzeneethanamine, 4-chloro-alpha-methyl-

Registry Number: 64-12-0

Descriptor UI: D010133

Alternative terms: p-Chloroamphetamine; p Chloroamphetamine; para-Chloroamphetamine; para Chloroamphetamine; Parachloroamphetamine; p-Chloramphetamine; p Chloramphetamine; Ly-123362; Ly 123362; Ly123362; LY-121860; LY 121860; LY121860;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Serotonin Agents;

Tree Number: D02.092.471.683.152.200;

History Note: 91(75); was see under AMPHETAMINES 1975-90