p-Chloroamphetamine
Research News and Information

Sunday, November 22, 2009

Effect of yokukansan, a traditional Japanese medicine, on social and aggressive behaviour of para-chloroamphetamine-injected rats.

30 Aug 2009 OBJECTIVES: Yokukansan, a traditional Japanese medicine, has been approved by the Ministry of Health, Labour, and Welfare of Japan as a remedy for neurosis, insomnia or night crying and irritability in children. It has recently been reported to ... Read more...

Altered postsynaptic-density-levels of caldendrin in the para-chloroamphetamine-induced serotonin syndrome but not in the rat ketamine model of psychosis.

16 Feb 2009 Caldendrin is a synaptic calcium sensor protein that is tightly associated with the postsynaptic density (PSD). Previous work has shown that the association of the protein with the synapse is highly dynamic and is increased in an activity-dependent ... Read more...

Serotonin depletion increases nociception-evoked trigeminal NMDA receptor phosphorylation.

9 Feb 2009 OBJECTIVE: To investigate the effect of serotonin depletion on phosphorylation and expression of NR1 subunit of N-methyl-D-aspartate (NMDA) receptor in trigeminal nucleus caudalis (TNC), and on trigeminal nociception evoked by dural inflammation. ... Read more...

Latest indexed articles for 'p-Chloroamphetamine'

These are the very latest articles for this heading:

• Effect of yokukansan, a traditional Japanese medicine, on social and aggressive behaviour of para-chloroamphetamine-injected rats. 30 Aug 2009
• Altered postsynaptic-density-levels of caldendrin in the para-chloroamphetamine-induced serotonin syndrome but not in the rat ketamine model of psychosis. 16 Feb 2009
• Serotonin depletion increases nociception-evoked trigeminal NMDA receptor phosphorylation. 9 Feb 2009
• An experimental approach to the interrelationship between hyperthyroidism and ejaculation latency time in male rats. 15 Dec 2008
• NMDA receptor blockade maintains correlated motor neuron firing and delays synapse competition at developing neuromuscular junctions. Sep 2008
• Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation. 10 Jun 2008
• Acquisition and retention of enhanced active avoidance are unaffected by interference with serotonergic activity. 3 Feb 2008
• Regulation of extracellular serotonin levels and brain-derived neurotrophic factor in rats with high and low exploratory activity. 2 Dec 2007
• The anxiolytic-like effect of the selective 5-HT6 receptor antagonist SB-399885: the impact of benzodiazepine receptors. 21 Nov 2007
• Serotonergic and noradrenergic lesions suppress the enhancing effect of maternal exercise during pregnancy on learning and memory in rat pups. 15 Nov 2007
• Study into a possible mechanism responsible for the antidepressant-like activity of the selective 5-HT6 receptor antagonist SB-399885 in rats. 30 Oct 2007
• Drugs of abuse specifically sensitize noradrenergic and serotonergic neurons via a non-dopaminergic mechanism. 3 Sep 2007
• Rat behavior after chronic variable stress and partial lesioning of 5-HT-ergic neurotransmission: effects of citalopram. 12 Aug 2007
• Changes in regional long-term oxidative metabolism induced by partial serotonergic denervation and chronic variable stress in rat brain. 9 Aug 2007
• Pharmacokinetic-pharmacodynamic modeling of the effect of fluvoxamine on p-chloroamphetamine-induced behavior. 26 Jul 2007
• CB1-cannabinoid receptors are involved in the modulation of non-synaptic [3H]serotonin release from the rat hippocampus. 12 Jul 2007
• Uncoupling between noradrenergic and serotonergic neurons as a molecular basis of stable changes in behavior induced by repeated drugs of abuse. 28 Jun 2007
• Effects of reserpine and p-chloroamphetamine on 5-HT metabolism and release in the cerebral ganglia of Inachis io (Lepidoptera). 30 May 2007
• The effects of p-chloroamphetamine, methamphetamine and 3,4-methylenedioxymethamphetamine (ecstasy) on the gene expression of cytoskeletal proteins in the rat brain. 27 Feb 2007
• Relationship between limbic and cortical 5-HT neurotransmission and acquisition and reversal learning in a go/no-go task in rats. Oct 2006

See a longer list of these articles.

Technical information about 'p-Chloroamphetamine'

Definition: Chlorinated analog of AMPHETAMINE. Potent neurotoxin that causes release and eventually depletion of serotonin in the CNS. It is used as a research tool.

Chemical name: Benzeneethanamine, 4-chloro-alpha-methyl-

Registry Number: 64-12-0

Descriptor UI: D010133

Alternative terms: p-Chloroamphetamine; p Chloroamphetamine; para-Chloroamphetamine; para Chloroamphetamine; Parachloroamphetamine; p-Chloramphetamine; p Chloramphetamine; Ly-123362; Ly 123362; Ly123362; LY-121860; LY 121860; LY121860;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Serotonin Agents;

Tree Number: D02.092.471.683.152.200;

History Note: 91(75); was see under AMPHETAMINES 1975-90