P-Glycoprotein
Research News and Information

Sunday, November 22, 2009

Vincristine: Can its therapeutic index be enhanced?

13 Dec 2009 Vincristine is one of the most widely used and more effective drugs in paediatric oncology. The dose-limiting toxicity of neuropathy, lack of proven neuroprotective measures and an incomplete understanding of the pharmacokinetics and ... Read more...

CD44-positive cells are responsible for gemcitabine resistance in pancreatic cancer cells.

13 Nov 2009 Accumulating evidence suggests that tumors are composed of a heterogeneous cell population with a small subset of cancer stem cells (CSCs) that sustain tumor formation and growth. Recently, there have been efforts to explain drug resistance of ... Read more...

Enhanced MDR1 expression and chemoresistance of cancer stem cells derived from glioblastoma.

30 Oct 2009 We established a cancer stem (CS) cell line, U87CS, by means of spheroid culture of U87MG cells derived from glioblastoma (GBM) in neuronal stem cell medium. U87CS cells presented positive immunohistochemical staining for multidrug resistance (MDR)1 ... Read more...

Latest indexed articles for 'P-Glycoprotein'

These are the very latest articles for this heading:

• Vincristine: Can its therapeutic index be enhanced? 13 Dec 2009
• CD44-positive cells are responsible for gemcitabine resistance in pancreatic cancer cells. 13 Nov 2009
• Enhanced MDR1 expression and chemoresistance of cancer stem cells derived from glioblastoma. 30 Oct 2009
• Synthesis and small-animal positron emission tomography evaluation of [11C]-elacridar as a radiotracer to assess the distribution of P-glycoprotein at the blood-brain barrier. 6 Oct 2009
• Facilitation of drug resistance development by gamma-irradiation in human cancer cells. 29 Sep 2009
• Amplification of the ABCB1 region accompanied by a short sequence of 200bp from chromosome 2 in lung cancer cells. 29 Sep 2009
• The influence of chronic renal failure on drug metabolism and transport. 21 Sep 2009
• Severe cardiac failure in a patient with multiple sclerosis following low-dose mitoxantrone treatment. 20 Sep 2009
• Expression of multidrug resistance proteins in prostate cancer is related with cell sensitivity to chemotherapeutic drugs. 13 Sep 2009
• Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. 4 Sep 2009
• Antitumor immunity and cancer stem cells. 30 Aug 2009
• Novel pepper extract for enhanced P-glycoprotein inhibition. 30 Aug 2009
• Utility of unbound plasma drug levels and P-glycoprotein transport data in prediction of central nervous system exposure. 30 Aug 2009
• Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers. 30 Aug 2009
• Evaluation of the flavonoid oroxylin A as an inhibitor of P-glycoprotein-mediated cellular efflux. 30 Aug 2009
• Thalidomide alters nuclear architecture without ABCB1 gene modulation in drug-resistant myeloma cells. 30 Aug 2009
• Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound. 30 Aug 2009
• A combination of proatherogenic single-nucleotide polymorphisms is associated with increased risk of coronary artery disease and myocardial infarction in Asian Indians. 30 Aug 2009
• MDR1 C3435T polymorphism indicates a different outcome in advanced multiple myeloma. 27 Aug 2009
• ESRD impairs nonrenal clearance of fexofenadine but not midazolam. 18 Aug 2009

See a longer list of these articles.

Technical information about 'P-Glycoprotein'

Definition: A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).

Registry Number: 0

Descriptor UI: D020168

Alternative terms: P-Glycoprotein; P Glycoprotein; PGY-1 Protein; PGY 1 Protein; Multidrug Resistance Protein 1; ATP-Binding Cassette, Sub-Family B, Member 1; P-gp; MDR1 Protein;

Related Mesh Headings: Drug Resistance, Multiple;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.157.530.100.652.500; D12.776.157.530.450.074.500.500.750; D12.776.395.550.020.610.610; D12.776.543.550.192.610.610; D12.776.543.585.100.610.500; D12.776.543.585.450.074.500.500.750;

History Note: 99; use P-GLYCOPROTEIN 1995-98

Technical Notes: P-GLYCOPROTEINS is also available