p38 Mitogen-Activated Protein Kinases
Research News and Information

Sunday, November 22, 2009

p38 MAPK mediated in compressive stress-induced chondrogenesis of rat bone marrow MSCs in 3D alginate scaffolds.

29 Nov 2009 Mesenchymal stem cells (MSCs) are well known to have the capability to form bone and cartilage, and chondrogenesis derived from MSCs is reported to be affected by mechanical stimuli. This research was aimed to study the effects of cyclic compressive ... Read more...

Oxidized low density lipoprotein decreases Rankl-induced differentiation of osteoclasts by inhibition of Rankl signaling.

29 Nov 2009 The role of OxLDL in the generation and progression of atherosclerosis is well admitted. In addition, it is well known that atherosclerosis is often accompanied by perturbations in bone remodeling, resulting in osteoporosis. In the current studies, ... Read more...

p38 Mitogen-activated protein kinase and hematologic malignancies.

30 Oct 2009 CONTEXT: p38 mitogen-activated protein kinase (MAPK) signaling has been implicated in responses ranging from apoptosis to cell cycle, induction of expression of cytokine genes, and differentiation. This plethora of activators conveys the complexity ... Read more...

Latest indexed articles for 'p38 Mitogen-Activated Protein Kinases'

These are the very latest articles for this heading:

• p38 MAPK mediated in compressive stress-induced chondrogenesis of rat bone marrow MSCs in 3D alginate scaffolds. 29 Nov 2009
• Oxidized low density lipoprotein decreases Rankl-induced differentiation of osteoclasts by inhibition of Rankl signaling. 29 Nov 2009
• p38 Mitogen-activated protein kinase and hematologic malignancies. 30 Oct 2009
• The effects of electroacupuncture on TH1/TH2 cytokine mRNA expression and mitogen-activated protein kinase signaling pathways in the splenic T cells of traumatized rats. 30 Oct 2009
• Role of p38 MAPK pathway in induction of iNOS expression in neutrophils and peripheral blood mononuclear cells in patients with squamous cell carcinoma of the oral cavity. 30 Oct 2009
• Involvement of cytosolic phospholipase A2alpha in MMP-9 up-regulation. 30 Oct 2009
• Leptin attenuates hypoxia/reoxygenation-induced activation of the intrinsic pathway of apoptosis in rat H9c2 cells. 30 Oct 2009
• Calpain inhibitors prevent p38 MAPK activation and germ cell apoptosis after heat stress in pubertal rat testes. 30 Oct 2009
• Impaired TNFalpha-induced A20 expression in E1A/Ras-transformed cells. 11 Oct 2009
• The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding. 3 Oct 2009
• Local wound p38 MAPK inhibition attenuates burn-induced cardiac dysfunction. 29 Sep 2009
• T cell receptor signaling induced by an analog peptide of type II collagen requires activation of Syk. 29 Sep 2009
• Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions. 29 Sep 2009
• Alterations in the temporal expression and function of cadherin-7 inhibit cell migration and condensation during chondrogenesis of chick limb mesenchymal cells in vitro. 29 Sep 2009
• Apoptosis and autophagy: Regulation of caspase-9 by phosphorylation. 27 Sep 2009
• Prevention of Clostridium sordellii lethal toxin-induced apoptotic cell death by tauroursodeoxycholic acid. 27 Sep 2009
• Timosaponin B-II inhibits pro-inflammatory cytokine induction by lipopolysaccharide in BV2 cells. 24 Sep 2009
• CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation. 21 Sep 2009
• p38 MAPK-dependent phagocytic encapsulation confers infection tolerance in Drosophila. 15 Sep 2009
• Transcriptional upregulation of mitochondrial uncoupling protein 2 protects against oxidative stress-associated neurogenic hypertension. 15 Sep 2009

See a longer list of these articles.

Technical information about 'p38 Mitogen-Activated Protein Kinases'

Definition: A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes including CELL GROWTH PROCESSES; CELL DIFFERENTIATION; APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated in response to bacterial pathogens.

Registry Number: EC 2.7.1.37

Descriptor UI: D048051

Alternative terms: p38 Mitogen-Activated Protein Kinases; p38 Mitogen Activated Protein Kinases; p38 MAP Kinase; MAP Kinase, p38; p38 Protein Kinase; Protein Kinase, p38; p38 SAPK; Mitogen-Activated Protein Kinase p38; Mitogen Activated Protein Kinase p38; p38 MAPK; MAPK, p38;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.913.696.620.682.700.567.878; D08.811.913.696.620.682.700.646.750.843; D12.644.360.450.835; D12.776.476.450.835;

History Note: 2005(1994)