Pain - Drug therapy
Research News and Information

Sunday, November 22, 2009

Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain.

2 Nov 2009 Previous studies of peripheral immune cells have documented that activation of adenosine 2A receptors (A(2A)Rs) decrease proinflammatory cytokine release and increase release of the potent anti-inflammatory cytokine, interleukin-10 (IL-10). Given ... Read more...

Direct evidence for spinal cord involvement in placebo analgesia.

14 Oct 2009 Placebo analgesia is a prime example of the impact that psychological factors have on pain perception. We used functional magnetic resonance imaging of the human spinal cord to test the hypothesis that placebo analgesia results in a reduction of ... Read more...

Discovery of 1-[4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic pain.

6 Oct 2009 We report the synthesis and SAR of a series of novel azaindole CB(2) agonists. 6-Azaindole 18 showed activity in an acute pain model but was inactive in a chronic model. 18 is a Pgp substrate with low brain penetration. The template was redesigned, ... Read more...

Latest indexed articles for 'Pain - Drug therapy'

These are the very latest articles for this heading:

• Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain. 2 Nov 2009
• Direct evidence for spinal cord involvement in placebo analgesia. 14 Oct 2009
• Discovery of 1-[4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic pain. 6 Oct 2009
• Contribution of endogenous opioids to gonadal hormones-induced temporomandibular joint antinociception. 29 Sep 2009
• Antinociceptive effects of epidural administration of hydromorphone in conscious cats. 29 Sep 2009
• Proposed FDA rules on painkillers in U.S. Rile cancer community. 29 Sep 2009
• StatBite: cancer pain. 29 Sep 2009
• Adductor-related groin pain in recreational athletes: role of the adductor enthesis, magnetic resonance imaging, and entheseal pubic cleft injections. 29 Sep 2009
• Commentary. 29 Sep 2009
• Commentary. 29 Sep 2009
• Unexpected urine drug testing results in a hospice patient on high-dose morphine therapy. 29 Sep 2009
• The "1+1" protocol: risks, benefits, and alternatives. 29 Sep 2009
• [Adequate analgesia in the elderly patients. Good pain control cannot be a coincidence] 22 Sep 2009
• Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747). 22 Sep 2009
• Incorporating multiple interventions in meta-analysis: an evaluation of the mixed treatment comparison with the adjusted indirect comparison. 19 Sep 2009
• Improving the management of chronic non-malignant pain and reducing problems associated with prescription opioids. 19 Sep 2009
• Impact of opioid rescue medication for breakthrough pain on the efficacy and tolerability of long-acting opioids in patients with chronic non-malignant pain. 4 Sep 2009
• Self-report of alcohol use for pain in a multi-ethnic community sample. 30 Aug 2009
• Skeletal versus skin traction before definitive management of pediatric femur fractures: a comparison of patient narcotic requirements. 30 Aug 2009
• The course of pain in Bell's palsy: treatment with prednisolone and valacyclovir. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Pain'

Definition: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Descriptor UI: D010146

Alternative terms: Pain; Pain, Burning; Burning Pain; Burning Pains; Pains, Burning; Suffering, Physical; Physical Suffering; Physical Sufferings; Sufferings, Physical; Pain, Migratory; Migratory Pain; Migratory Pains; Pains, Migratory; Pain, Radiating; Pains, Radiating; Radiating Pain; Radiating Pains; Pain, Splitting; Pains, Splitting; Splitting Pain; Splitting Pains; Ache; Aches; Pain, Crushing; Crushing Pain; Crushing Pains; Pains, Crushing;

Related Mesh Headings: Analgesia; Pain Insensitivity, Congenital; Analgesics; Hyperalgesia; Palliative Care;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C10.597.617; C23.888.592.612; C23.888.646; F02.830.816.444; G11.561.600.810.444;

Technical Notes: general; prefer specific precoordinated locational pain terms, like ABDOMINAL PAIN; CHEST PAIN, etc.; / diag: consider also PAIN MEASUREMENT but PAIN / diag is probably PAIN / etiol; / ther: consider also PALLIATIVE CARE ( = pain relief without cure); / physiopathol: PAIN THRESHOLD is also available; chronic pain = PAIN (IM) + CHRONIC DISEASE (NIM): do not equate with PAIN, INTRACTABLE; congenital absence of pain = PAIN INSENSITIVITY, CONGENITAL