Parathyroid Hormone - Metabolism
Research News and Information

Sunday, November 22, 2009

The influence of chronic renal failure on drug metabolism and transport.

21 Sep 2009 Chronic renal failure (CRF) has been shown, in animal models and clinical studies, to significantly reduce nonrenal clearance and to alter the bioavailability of predominantly metabolized drugs. Phase II reactions and drug transporters such as ... Read more...

Hyperparathyroidism and vitamin D deficiency predispose to bone loss in renal transplant recipients.

13 Sep 2009 BACKGROUND: Bone disease is common postrenal transplantation resulting in increased fracture rates and morbidity. The cause is multifactorial including hyperparathyroidism, corticosteroids, and possibly calcium and vitamin D deficiencies. The aim of ... Read more...

Sustained cyclic AMP production by parathyroid hormone receptor endocytosis.

21 Aug 2009 Cell signaling mediated by the G protein-coupled parathyroid hormone receptor type 1 (PTHR) is fundamental to bone and kidney physiology. It has been unclear how the two ligand systems--PTH, endocrine and homeostatic, and PTH-related peptide ... Read more...

Latest indexed articles for 'Parathyroid Hormone - Metabolism'

These are the very latest articles for this heading:

• When two keys fit one lock, surprises follow. 29 Sep 2009
• The influence of chronic renal failure on drug metabolism and transport. 21 Sep 2009
• Hyperparathyroidism and vitamin D deficiency predispose to bone loss in renal transplant recipients. 13 Sep 2009
• Sustained cyclic AMP production by parathyroid hormone receptor endocytosis. 21 Aug 2009
• Indirect regulation of PTH by estrogens may require FGF23. 21 Jul 2009
• Short-acting 5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as orally-active calcium-sensing receptor antagonists. 6 Jul 2009
• The relationship between chronic hepatitis B infection and bone mineral, metabolism in peritoneal dialysis patients. 29 Jun 2009
• The gutsy side of bone. 29 Jun 2009
• Peripheral parameters of thyroid hormone action in resistance to thyroid hormone syndrome: a focus on mineral metabolism. 29 Jun 2009
• Human PTH gene regulation in vivo using transgenic mice. 29 Jun 2009
• Hypophosphatemia: the common denominator of all rickets. 4 Jun 2009
• The role of parathyroid hormone-related protein (PTHrP) in the pathophysiology of diabetes mellitus. 30 May 2009
• Vitamin D: emerging new roles in insulin sensitivity. 30 May 2009
• The effect of RANKL and OPG on bone mineral density in pre-dialysis chronic renal failure. 30 May 2009
• Paricalcitol and outcome: a manual on how a vitamin D receptor activator (VDRA) can help us to get down the "U". 30 May 2009
• A theoretical model for simulating effect of parathyroid hormone on bone metabolism at cellular level. 30 May 2009
• The full-length calcium-sensing receptor dampens the calcemic response to 1alpha,25(OH)2 vitamin D3 in vivo independently of parathyroid hormone. 25 May 2009
• Sp proteins and Runx2 mediate regulation of matrix gla protein (MGP) expression by parathyroid hormone. 13 May 2009
• Parathyroid hormone activates TRPV5 via PKA-dependent phosphorylation. 5 May 2009
• Calcimimetic inhibits late-stage cyst growth in ADPKD. 5 May 2009

See a longer list of these articles.

Technical information about 'Parathyroid Hormone'

Definition: A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.

Registry Number: 0

Descriptor UI: D010281

Alternative terms: Parathyroid Hormone; Hormone, Parathyroid; PTH (1-84); Parathyroid Hormone (1-84); Parathormone; Parathyrin; Parathyroid Hormone Peptide (1-34); PTH(1-34); Parathyroid Hormone (1-34);

Related Mesh Headings: Hypoparathyroidism; Parathyroid Hormone-Related Protein;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D06.472.699.590; D12.644.548.587;

History Note: 2004(1963-1981); for PARATHYROID HORMONE PEPTIDE (1-34) use TERIPARATIDE 1997-2007

Technical Notes: /defic: consider also HYPOPARATHYROIDISM