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Parkinson Disease - Physiopathology
Research News and Information
Definition of 'Parkinson Disease'A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75) |
Saturday, November 21, 2009
Nov 2009 
OBJECTIVE: To investigate the incidence of and risk factors for cognitive impairment in a large, well-defined clinical trial cohort of patients with early Parkinson disease (PD). METHODS: The Mini-Mental State Examination (MMSE) was administered ... Read more...
Functional magnetic stimulation in constipation associated with Parkinson's disease.
30 Oct 2009 OBJECTIVE: The aims of this study were: (i) to investigate the effect of functional magnetic stimulation on total colonic transit time in patients with Parkinson's disease; (ii) to compare the changes in dynamic recto-anal behaviour during filling ... Read more...
10 Oct 2009 Mutations in the neuronal protein alpha-synuclein cause familial Parkinson disease. Phosphorylation of alpha-synuclein at serine 129 is prominent in Parkinson disease and influences alpha-synuclein neurotoxicity. Here we report that alpha-synuclein ... Read more...
Latest indexed articles for 'Parkinson Disease - Physiopathology'
These are the very latest articles for this heading:
- Incidence of and risk factors for cognitive impairment in an early Parkinson disease clinical trial cohort. Nov 2009
- Functional magnetic stimulation in constipation associated with Parkinson's disease. 30 Oct 2009
- Mice with reduced vesicular monoamine storage content display nonmotor features of Parkinson's disease.
12 Oct 2009 - Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation. 10 Oct 2009
- Neuroinflammation and Parkinson disease: the silent battleground. 5 Oct 2009
- Driving under low-contrast visibility conditions in Parkinson disease. 4 Oct 2009
- Dopamine D2 receptor knockout mice develop features of Parkinson disease. 29 Sep 2009
- Modeling Parkinson's disease. 29 Sep 2009
- Microstimulation-induced inhibition as a tool to aid targeting the ventral border of the subthalamic nucleus. 29 Sep 2009
- Identification of the subthalamic nucleus in deep brain stimulation surgery with a novel wavelet-derived measure of neural background activity. 29 Sep 2009
- The Coalition Against Major Diseases: developing tools for an integrated drug development process for Alzheimer's and Parkinson's diseases. 29 Sep 2009
- Reduction of the postexcitatory cortical inhibition upon paired-click auditory stimulation in patients with Parkinson's disease. 17 Sep 2009
- Cortical correlates of the basic and first harmonic frequency of Parkinsonian tremor. 10 Sep 2009
- Deciphering the tremor enigma. 9 Sep 2009
- Neuroanatomical correlates of impaired decision-making and facial emotion recognition in early Parkinson's disease. 2 Sep 2009
- Advanced time-series analysis of MEG data as a method to explore olfactory function in healthy controls and Parkinson's disease patients. 30 Aug 2009
- Comparison of risk factor profiles in incidental Lewy body disease and Parkinson disease. 30 Aug 2009
- Evidence of subthalamic PGO-like waves during REM sleep in humans: a deep brain polysomnographic study. 30 Aug 2009
- Distinct hippocampal and basal ganglia contributions to probabilistic learning and reversal. 30 Aug 2009
- Mitochondrial morphogenesis, distribution, and Parkinson disease: insights from PINK1. 30 Aug 2009
See a longer list of these articles.
Technical information about 'Parkinson Disease'
Definition: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
Descriptor UI: D010300
Alternative terms: Parkinson Disease; Idiopathic Parkinson's Disease; Lewy Body Parkinson Disease; Lewy Body Parkinson's Disease; Primary Parkinsonism; Parkinsonism, Primary; Parkinson Disease, Idiopathic; Parkinson's Disease; Parkinson's Disease, Idiopathic; Parkinson's Disease, Lewy Body; Idiopathic Parkinson Disease; Paralysis Agitans;
Related Mesh Headings: Lewy Bodies;
Allowable Qualifiers: blood; cerebrospinal fluid; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;
Tree Number: C10.228.140.079.862.500; C10.228.662.600.400; C10.574.812;
History Note: 1979(1963)
Technical Notes: drug ther: consider also ANTIPARKINSON AGENTS; /chem ind = PARKINSON DISEASE, SECONDARY/chem ind