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Parkinson Disease
Research News and Information
Definition of 'Parkinson Disease'A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75) |
Saturday, November 21, 2009
Nov 2009 
OBJECTIVE: To investigate the incidence of and risk factors for cognitive impairment in a large, well-defined clinical trial cohort of patients with early Parkinson disease (PD). METHODS: The Mini-Mental State Examination (MMSE) was administered ... Read more...
Functional magnetic stimulation in constipation associated with Parkinson's disease.
30 Oct 2009 OBJECTIVE: The aims of this study were: (i) to investigate the effect of functional magnetic stimulation on total colonic transit time in patients with Parkinson's disease; (ii) to compare the changes in dynamic recto-anal behaviour during filling ... Read more...
New biochemical approaches towards understanding the Parkinson's disease-associated kinase, LRRK2.
21 Oct 2009 Some 5 years ago, it was first discovered that mutations in the gene encoding LRRK2 (leucine-rich repeat protein kinase 2) are tightly linked with a subset of familial PD (Parkinson's disease). Before this genetic association, LRRK2 had never been ... Read more...
Latest indexed articles for 'Parkinson Disease'
These are the very latest articles for this heading:
- Incidence of and risk factors for cognitive impairment in an early Parkinson disease clinical trial cohort. Nov 2009
- Functional magnetic stimulation in constipation associated with Parkinson's disease. 30 Oct 2009
- New biochemical approaches towards understanding the Parkinson's disease-associated kinase, LRRK2. 21 Oct 2009
- Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. 21 Oct 2009
- Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease. 20 Oct 2009
- Family history of melanoma and Parkinson disease risk. 18 Oct 2009
- SnapShot: pathogenesis of Parkinson's disease.
14 Oct 2009 - Neuroscience. Fetal cells again? 14 Oct 2009
- Mice with reduced vesicular monoamine storage content display nonmotor features of Parkinson's disease. 12 Oct 2009
- Bilateral subthalamotomy through dbs electrodes: A rescue option for device-related infection. 11 Oct 2009
- Identification of a novel functional deletion variant in the 5'-UTR of the DJ-1 gene. 11 Oct 2009
- Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation. 10 Oct 2009
- Neuroinflammation and Parkinson disease: the silent battleground. 5 Oct 2009
- Driving under low-contrast visibility conditions in Parkinson disease. 4 Oct 2009
- [Dopamine agonist therapy in early Parkinson's disease. A survey of a Cochrane review] 3 Oct 2009
- Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease. 2 Oct 2009
- Dopamine D2 receptor knockout mice develop features of Parkinson disease. 29 Sep 2009
- Modeling Parkinson's disease. 29 Sep 2009
- Microstimulation-induced inhibition as a tool to aid targeting the ventral border of the subthalamic nucleus. 29 Sep 2009
- Identification of the subthalamic nucleus in deep brain stimulation surgery with a novel wavelet-derived measure of neural background activity. 29 Sep 2009
See a longer list of these articles.
Technical information about 'Parkinson Disease'
Definition: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
Descriptor UI: D010300
Alternative terms: Parkinson Disease; Idiopathic Parkinson's Disease; Lewy Body Parkinson Disease; Lewy Body Parkinson's Disease; Primary Parkinsonism; Parkinsonism, Primary; Parkinson Disease, Idiopathic; Parkinson's Disease; Parkinson's Disease, Idiopathic; Parkinson's Disease, Lewy Body; Idiopathic Parkinson Disease; Paralysis Agitans;
Related Mesh Headings: Lewy Bodies;
Allowable Qualifiers: blood; cerebrospinal fluid; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;
Tree Number: C10.228.140.079.862.500; C10.228.662.600.400; C10.574.812;
History Note: 1979(1963)
Technical Notes: drug ther: consider also ANTIPARKINSON AGENTS; /chem ind = PARKINSON DISEASE, SECONDARY/chem ind