Pentylenetetrazole - Pharmacology
Research News and Information

Sunday, November 22, 2009

Topiramate and vitamin e modulate the electroencephalographic records, brain microsomal and blood antioxidant redox system in pentylentetrazol-induced seizure of rats.

8 Jun 2009 We investigated the effects of vitamin E and topiramate (TPM) administrations on pentylentetrazol (PTZ)-induced blood and brain toxicity in rats. Forty rats were randomly divided into five equal groups. The first and second groups were used for the ... Read more...

Detection of transgenerational spermatogenic inheritance of adult male acquired CNS gene expression characteristics using a Drosophila systems model.

31 May 2009 Available instances of inheritance of epigenetic transgenerational phenotype are limited to environmental exposures during embryonic and adult gonadal development. Adult exposures can also affect gametogenesis and thereby potentially result in ... Read more...

Hyperthermic seizures and hyperthermia in immature rats modify the subsequent pentylenetetrazole-induced seizures.

13 May 2009 It has been described that febrile seizures during infancy increase risk of subsequent non-febrile seizures during the adulthood. However, latency period between febrile seizure and the onset of the first spontaneous seizure has not been evaluated. ... Read more...

Latest indexed articles for 'Pentylenetetrazole - Pharmacology'

These are the very latest articles for this heading:

• Topiramate and vitamin e modulate the electroencephalographic records, brain microsomal and blood antioxidant redox system in pentylentetrazol-induced seizure of rats. 8 Jun 2009
• Detection of transgenerational spermatogenic inheritance of adult male acquired CNS gene expression characteristics using a Drosophila systems model. 31 May 2009
• Hyperthermic seizures and hyperthermia in immature rats modify the subsequent pentylenetetrazole-induced seizures. 13 May 2009
• Antagonists of group I metabotropic glutamate receptors and cortical afterdischarges in immature rats. 17 Apr 2009
• Preclinical assessment of proconvulsant drug activity and its relevance for predicting adverse events in humans. 14 Mar 2009
• Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice. 12 Feb 2009
• Role of glutamate and GABA transporters in development of pentylenetetrazol-kindling. 22 Jan 2009
• [Seizure activity in the EEG of rats sensitive and resistant to pentylenetetrazol kindling] 30 Dec 2008
• Effects of progesterone on total brain tissue adenosine deaminase activity in experimental epilepsy. 30 Dec 2008
• Anticonvulsant properties of saponins from Ficus platyphylla stem bark. 24 Dec 2008
• Ketogenic diet is antiepileptogenic in pentylenetetrazole kindled mice and decrease levels of N-acylethanolamines in hippocampus. 28 Nov 2008
• Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype. 17 Nov 2008
• Time course of changes in the concentration of kynurenic acid in the brain of pentylenetetrazol-kindled rats. 17 Nov 2008
• Intracranial self-stimulation enhances neurogenesis in hippocampus of adult mice and rats. 5 Nov 2008
• A few facts from the history of selected biological treatment methods in psychiatry. 30 Oct 2008
• JunB is a repressor of MMP-9 transcription in depolarized rat brain neurons. 9 Oct 2008
• Morphine dependence increases the response to a brief pentylenetetrazol administration in rat hippocampal CA1 in vitro. 4 Oct 2008
• Hippocampal-dependent learning requires a functional circadian system. 29 Sep 2008
• Tyrianthinic acids from Ipomoea tyrianthina and their antimycobacterial activity, cytotoxicity, and effects on the central nervous system. 29 Sep 2008
• Different effects of two N-methyl-D-aspartate receptor antagonists on seizures, spontaneous behavior, and motor performance in immature rats. 28 Sep 2008

See a longer list of these articles.

Technical information about 'Pentylenetetrazole'

Definition: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.

Chemical name: 5H-Tetrazolo(1,5-a)azepine, 6,7,8,9-tetrahydro-

Registry Number: 54-95-5

Descriptor UI: D010433

Alternative terms: Pentylenetetrazole; Pentylenetetrazol; Pentetrazole; Leptazole; Pentamethylenetetrazole; Cardiazol; Corasol; Korazole; Korazol; Corazol; Corazole; Pentazol; Metrazol; Metrazole;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Convulsants; GABA Antagonists;

Tree Number: D03.383.066.600;