Pentylenetetrazole
Research News and Information

Sunday, November 22, 2009

Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport.

4 Sep 2009 Astrocytes are critical participants in synapse development and function, but their role in synaptic plasticity is unclear. Eph receptors and their ephrin ligands have been suggested to regulate neuron-glia interactions, and EphA4-mediated ephrin ... Read more...

Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling.

24 Aug 2009 Inhibitory interneurons are crucially important for cerebral cortex function and behavior. The mechanisms controlling inhibitory interneuron diversification and allocation to distinct cortical areas remain poorly understood. GDNF (glial cell ... Read more...

Benzothiazole incorporated barbituric acid derivatives: synthesis and anticonvulsant screening.

30 Jul 2009 A series of 1-(6-substituted-1,3-benzothiazol-2-yl)-3-(substituted phenyl)hexahydro-2,4,6-pyrimidinetriones 4a-t were synthesized starting from substituted anilines. These compounds contained two active anticonvulsant pharmacophores, benzothiazole ... Read more...

Latest indexed articles for 'Pentylenetetrazole'

These are the very latest articles for this heading:

• Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport. 4 Sep 2009
• Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling. 24 Aug 2009
• Benzothiazole incorporated barbituric acid derivatives: synthesis and anticonvulsant screening. 30 Jul 2009
• Synthesis of novel 2,5-disubstituted 1,3,4-thiadiazoles for their potential anticonvulsant activity: pharmacophoric model studies. 30 Jul 2009
• The role of polar phytocomplexes on anticonvulsant effects of leaf extracts of Lippia alba (Mill.) N.E. Brown chemotypes. 29 Jun 2009
• Effects of pentylenetetrazol-induced brief convulsive seizures on spatial memory and fear memory. 28 Jun 2009
• Anticonvulsant, anxiolytic, and sedative properties of the roots of Nauclea latifolia Smith in mice. 25 Jun 2009
• Pharmacological inhibition of inducible nitric oxide synthase attenuates the development of seizures in mice. 22 Jun 2009
• Central action of Araucaria angustifolia seed lectin in mice. 11 Jun 2009
• Topiramate and vitamin e modulate the electroencephalographic records, brain microsomal and blood antioxidant redox system in pentylentetrazol-induced seizure of rats. 8 Jun 2009
• Detection of transgenerational spermatogenic inheritance of adult male acquired CNS gene expression characteristics using a Drosophila systems model. 31 May 2009
• Postnatal caffeine treatment affects differently two pentylenetetrazol seizure models in rats. 31 May 2009
• Adenosine A2A receptor deficient mice are partially resistant to limbic seizures. 31 May 2009
• The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration. 26 May 2009
• Levetiracetam decreases the seizure activity and blood-brain barrier permeability in pentylenetetrazole-kindled rats with cortical dysplasia. 19 May 2009
• Hyperthermic seizures and hyperthermia in immature rats modify the subsequent pentylenetetrazole-induced seizures. 13 May 2009
• Additive anticonvulsant effects of creatine supplementation and physical exercise against pentylenetetrazol-induced seizures. 20 Apr 2009
• Antagonists of group I metabotropic glutamate receptors and cortical afterdischarges in immature rats. 17 Apr 2009
• Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models. 7 Apr 2009
• Effects of acute and repeated zolpidem treatment on pentylenetetrazole-induced seizure threshold and on locomotor activity: comparison with diazepam. 30 Mar 2009

See a longer list of these articles.

Technical information about 'Pentylenetetrazole'

Definition: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.

Chemical name: 5H-Tetrazolo(1,5-a)azepine, 6,7,8,9-tetrahydro-

Registry Number: 54-95-5

Descriptor UI: D010433

Alternative terms: Pentylenetetrazole; Pentylenetetrazol; Pentetrazole; Leptazole; Pentamethylenetetrazole; Cardiazol; Corasol; Korazole; Korazol; Corazol; Corazole; Pentazol; Metrazol; Metrazole;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Convulsants; GABA Antagonists;

Tree Number: D03.383.066.600;