Peptide Fragments - Antagonists & inhibitors
Research News and Information

Sunday, November 22, 2009

Crystallographic analysis of bacterial signal peptidase in ternary complex with arylomycin A2 and a beta-sultam inhibitor.

27 Sep 2009 Bacterial type I signal peptidase (SPase I), an essential membrane-bound endopeptidase with a unique Ser/Lys dyad mechanism, is being investigated as a potential novel antibiotic target. We present here binding and inhibition assays along with ... Read more...

Identification of an antiamyloidogenic substance from mulberry leaves.

24 Aug 2009 Fibrillar aggregates of amyloid beta-peptides are major constituents of the plaques found in the brains of patients with Alzheimer's disease, and have been implicated in the neurotoxicity of Alzheimer's. We previously reported that the methanol ... Read more...

Proteolytic cleavage of protein tyrosine phosphatase mu regulates glioblastoma cell migration.

16 Aug 2009 Glioblastoma multiforme (GBM), the most common malignant primary brain tumor, represents a significant disease burden. GBM tumor cells disperse extensively throughout the brain parenchyma, and the need for tumor-specific drug targets and ... Read more...

Latest indexed articles for 'Peptide Fragments - Antagonists & inhibitors'

These are the very latest articles for this heading:

• Crystallographic analysis of bacterial signal peptidase in ternary complex with arylomycin A2 and a beta-sultam inhibitor. 27 Sep 2009
• Identification of an antiamyloidogenic substance from mulberry leaves. 24 Aug 2009
• Proteolytic cleavage of protein tyrosine phosphatase mu regulates glioblastoma cell migration. 16 Aug 2009
• Oral administration of synthetic retinoid Am80 (Tamibarotene) decreases brain beta-amyloid peptides in APP23 mice. 29 Jun 2009
• Schisandrin B protects rat cortical neurons against Abeta1-42-induced neurotoxicity. 29 Jun 2009
• IRAK4 kinase activity is required for Th17 differentiation and Th17-mediated disease. 29 Jun 2009
• Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M. 29 Jun 2009
• The anticancer activity of lytic peptides is inhibited by heparan sulfate on the surface of the tumor cells. 13 Jun 2009
• Acute modulation of myocardial function by angiotensin 1-7. 10 Jun 2009
• Intrathecal substance P augments morphine-induced antinociception: possible relevance in the production of substance P N-terminal fragments. 7 Jun 2009
• Acteoside protects human neuroblastoma SH-SY5Y cells against beta-amyloid-induced cell injury. 7 Jun 2009
• Myelin basic protein binds to and inhibits the fibrillar assembly of Abeta42 in vitro. 7 Jun 2009
• Rationally designed dehydroalanine (DeltaAla)-containing peptides inhibit amyloid-beta (Abeta) peptide aggregation. 30 May 2009
• Alpha-helix targeting reduces amyloid-beta peptide toxicity. 18 May 2009
• The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection. 16 May 2009
• Amyloid beta protein: Abeta40 inhibits Abeta42 oligomerization. 11 May 2009
• Inhibition of collagen-induced arthritis by DNA vaccines encoding TCR Vbeta5.2 and TCR Vbeta8.2. 3 May 2009
• Anti-amyloid activity of the C-terminal domain of proSP-C against amyloid beta-peptide and medin. 3 May 2009
• Rescue of Abeta(1-42)-induced memory impairment in day-old chick by facilitation of astrocytic oxidative metabolism: implications for Alzheimer's disease. 29 Apr 2009
• Half-site inhibition of dimeric kinesin head domains by monomeric tail domains. 19 Apr 2009

See a longer list of these articles.

Technical information about 'Peptide Fragments'

Definition: Partial proteins formed by partial hydrolysis of complete proteins.

Registry Number: 0

Descriptor UI: D010446

Alternative terms: Peptide Fragments; Fragments, Peptide;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists; ultrastructure;

Tree Number: D12.644.541;

History Note: 74