Peptide Fragments - Genetics
Research News and Information

Sunday, November 22, 2009

DNA beta-amyloid(1-42) trimer immunization for Alzheimer disease in a wild-type mouse model.

26 Oct 2009 CONTEXT: DNA beta-amyloid(1-42) (Abeta42) trimer immunization was developed to produce specific T helper 2 cell (T(H)2)-type antibodies to provide an effective and safe therapy for Alzheimer disease (AD) by reducing elevated levels of Abeta42 ... Read more...

Vaccination with an adenoviral vector encoding the tumor antigen directly linked to invariant chain induces potent CD4(+) T-cell-independent CD8(+) T-cell-mediated tumor control.

29 Sep 2009 Antigen-specific immunotherapy is an attractive strategy for cancer control. In the context of antiviral vaccines, adenoviral vectors have emerged as a favorable means for immunization. Therefore, we chose a strategy combining use of these vectors ... Read more...

Structural basis for differential binding of the interleukin-8 monomer and dimer to the CXCR1 N-domain: role of coupled interactions and dynamics.

20 Sep 2009 Interleukin-8 (IL-8 or CXCL8) plays a critical role in orchestrating the immune response by binding and activating the receptor CXCR1 that belongs to the GPCR class. IL-8 exists as both monomers and dimers, and both bind CXCR1 but with differential ... Read more...

Latest indexed articles for 'Peptide Fragments - Genetics'

These are the very latest articles for this heading:

• DNA beta-amyloid(1-42) trimer immunization for Alzheimer disease in a wild-type mouse model. 26 Oct 2009
• Vaccination with an adenoviral vector encoding the tumor antigen directly linked to invariant chain induces potent CD4(+) T-cell-independent CD8(+) T-cell-mediated tumor control. 29 Sep 2009
• Structural basis for differential binding of the interleukin-8 monomer and dimer to the CXCR1 N-domain: role of coupled interactions and dynamics. 20 Sep 2009
• Striatal expression of a calmodulin fragment improved motor function, weight loss, and neuropathology in the R6/2 mouse model of Huntington's disease. 14 Sep 2009
• N-terminal aliphatic residues dictate the structure, stability, assembly, and small molecule binding of the coiled-coil region of cartilage oligomeric matrix protein. 13 Sep 2009
• The native-like interactions between SNase121 and SNase(111-143) fragments induce the recovery of their native-like structures and the ability to degrade DNA. 13 Sep 2009
• Suppression of ongoing T cell-mediated autoimmunity by peptide-MHC class II dimer vaccination. 12 Sep 2009
• Efficient cross-priming of antiviral CD8+ T cells by antigen donor cells is GRP94 independent. 12 Sep 2009
• Angiotensin-(1-7), an alternative metabolite of the renin-angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat. 12 Sep 2009
• Esculentin-1b(1-18)--a membrane-active antimicrobial peptide that synergizes with antibiotics and modifies the expression level of a limited number of proteins in Escherichia coli. 31 Aug 2009
• Impact of the transfer of sFlt-1 gene fragments on the ERK1/2 pathway of VEGF in vitro. 30 Aug 2009
• Apolipoprotein modulation of streptococcal serum opacity factor activity against human plasma high-density lipoproteins. 23 Aug 2009
• The Saccharomyces cerevisiae vacuolar acid trehalase is targeted at the cell surface for its physiological function. 22 Aug 2009
• Polymorphism of Alzheimer's Abeta17-42 (p3) oligomers: the importance of the turn location and its conformation. 17 Aug 2009
• Structural substrate conditions required for neutral endopeptidase-mediated natriuretic Peptide degradation. 13 Aug 2009
• HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele. 10 Aug 2009
• Self-peptides prolong survival in murine autoimmunity via reduced IL-2/IL-7-mediated STAT5 signaling, CD8 coreceptor, and V alpha 2 down-regulation. 10 Aug 2009
• Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein. 9 Aug 2009
• Modeling an electronic conductor based on natural peptide sequences. 8 Aug 2009
• Antigen specificity of gammadelta T cells depends primarily on the flanking sequences of CDR3delta. 5 Aug 2009

See a longer list of these articles.

Technical information about 'Peptide Fragments'

Definition: Partial proteins formed by partial hydrolysis of complete proteins.

Registry Number: 0

Descriptor UI: D010446

Alternative terms: Peptide Fragments; Fragments, Peptide;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists; ultrastructure;

Tree Number: D12.644.541;

History Note: 74