Peptide Fragments - Toxicity
Research News and Information

Monday, November 23, 2009

Two disaccharides and trimethylamine N-oxide affect Abeta aggregation differently, but all attenuate oligomer-induced membrane permeability.

20 Sep 2009 Interaction between aggregates of amyloid beta protein (Abeta) and membranes has been hypothesized by many to be a key event in the mechanism of neurotoxicity associated with Alzheimer's disease (AD). Proposed membrane-related mechanisms of ... Read more...

Protective effect of pyrroloquinoline quinone against Abeta-induced neurotoxicity in human neuroblastoma SH-SY5Y cells.

18 Aug 2009 The neurotoxicity of aggregated beta-amyloid (Abeta) has been implicated as a critical cause in the pathogenesis of Alzheimer's disease (AD). It can cause neurotoxicity in AD by evoking a cascade of oxidative damage-dependent apoptosis to neurons. ... Read more...

Essential involvement of the NMDA receptor in ethanol preconditioning-dependent neuroprotection from amyloid-betain vitro.

17 Aug 2009 In several epidemiological studies, moderate ethanol consumption has been associated with reduced risks of cognitive decline or Alzheimer's dementia. Of potential relevance is that brain cultures preconditioned with moderate ethanol concentrations ... Read more...

Latest indexed articles for 'Peptide Fragments - Toxicity'

These are the very latest articles for this heading:

• Two disaccharides and trimethylamine N-oxide affect Abeta aggregation differently, but all attenuate oligomer-induced membrane permeability. 20 Sep 2009
• Protective effect of pyrroloquinoline quinone against Abeta-induced neurotoxicity in human neuroblastoma SH-SY5Y cells. 18 Aug 2009
• Essential involvement of the NMDA receptor in ethanol preconditioning-dependent neuroprotection from amyloid-betain vitro. 17 Aug 2009
• Mechanism of docosahexaenoic acid-induced inhibition of in vitro Abeta1-42 fibrillation and Abeta1-42-induced toxicity in SH-S5Y5 cells. 15 Aug 2009
• Tripchlorolide protects neuronal cells from microglia-mediated beta-amyloid neurotoxicity through inhibiting NF-kappaB and JNK signaling. 13 Aug 2009
• Biological markers in cerebrospinal fluid (CSF) and evaluation of in vitro effect of CSF on PC12 cell line viability in Alzheimer's disease. 30 Jul 2009
• Silibinin attenuates amyloid beta(25-35) peptide-induced memory impairments: implication of inducible nitric-oxide synthase and tumor necrosis factor-alpha in mice. 26 Jul 2009
• Potential protection of curcumin against amyloid beta-induced toxicity on cultured rat prefrontal cortical neurons. 20 Jul 2009
• Influence of residue 22 on the folding, aggregation profile, and toxicity of the Alzheimer's amyloid beta peptide. 6 Jul 2009
• Schisandrin B protects rat cortical neurons against Abeta1-42-induced neurotoxicity. 29 Jun 2009
• AFPep, a novel drug for the prevention and treatment of breast cancer, does not disrupt the estrous cycle or fertility in rats. 29 Jun 2009
• Neuronal TIMP-1 release accompanies astrocytic MMP-9 secretion and enhances astrocyte proliferation induced by beta-amyloid 25-35 fragment. 29 Jun 2009
• Morphology and secondary structure of stable beta-oligomers formed by amyloid peptide PrP(106-126). 28 Jun 2009
• The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta (1-42) peptide. 20 Jun 2009
• Antioxidant effects of epicatechin on the hippocampal toxicity caused by amyloid-beta 25-35 in rats. 15 Jun 2009
• Hibifolin, a flavonol glycoside, prevents beta-amyloid-induced neurotoxicity in cultured cortical neurons. 15 Jun 2009
• Role of amyloid-beta glycine 33 in oligomerization, toxicity, and neuronal plasticity. 8 Jun 2009
• Acteoside protects human neuroblastoma SH-SY5Y cells against beta-amyloid-induced cell injury. 7 Jun 2009
• N-terminal pro-B-type natriuretic peptide and mortality in renal transplant recipients versus the general population. 25 May 2009
• Abeta oligomers and fibrillar aggregates induce different apoptotic pathways in LAN5 neuroblastoma cell cultures. 18 May 2009

See a longer list of these articles.

Technical information about 'Peptide Fragments'

Definition: Partial proteins formed by partial hydrolysis of complete proteins.

Registry Number: 0

Descriptor UI: D010446

Alternative terms: Peptide Fragments; Fragments, Peptide;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists; ultrastructure;

Tree Number: D12.644.541;

History Note: 74