Peptides
Research News and Information

Sunday, November 22, 2009

Cell based therapy for Duchenne muscular dystrophy.

29 Nov 2009 Mutations in the dystrophin gene cause an X-linked genetic disorder: Duchenne muscular dystrophy (DMD). Stem cell therapy is an attractive method to treat DMD because a small number of cells are required to obtain a therapeutic effect. Here, we ... Read more...

Salt dependence of an alpha-helical peptide folding energy landscapes.

15 Nov 2009 We used CD, UV resonance Raman spectroscopy, and molecular dynamics simulation to examine the impact of salts on the conformational equilibria and the Ramachandran Psi angle (un)folding Gibbs free energy landscape coordinate of a mainly polyalanine ... Read more...

A nanomedicine transports a peptide caspase-3 inhibitor across the blood-brain barrier and provides neuroprotection.

2 Nov 2009 Caspases play an important role as mediators of cell death in acute and chronic neurological disorders. Although peptide inhibitors of caspases provide neuroprotection, they have to be administered intracerebroventricularly because they cannot cross ... Read more...

Latest indexed articles for 'Peptides'

These are the very latest articles for this heading:

• Cell based therapy for Duchenne muscular dystrophy. 29 Nov 2009
• Salt dependence of an alpha-helical peptide folding energy landscapes. 15 Nov 2009
• A nanomedicine transports a peptide caspase-3 inhibitor across the blood-brain barrier and provides neuroprotection. 2 Nov 2009
• Role of tryptophan-tryptophan interactions in Trpzip beta-hairpin formation, structure, and stability. Nov 2009
• A library of fluorescent peptides for exploring the substrate specificities of prolyl isomerases. Nov 2009
• Role of hydrophobic and electrostatic interactions in coiled coil stability and specificity. Nov 2009
• Engineered cystine knot peptides that bind alphavbeta3, alphavbeta5, and alpha5beta1 integrins with low-nanomolar affinity. 30 Oct 2009
• Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease. 30 Oct 2009
• Enhanced MDR1 expression and chemoresistance of cancer stem cells derived from glioblastoma. 30 Oct 2009
• Positively selecting peptides: their job does not end in the thymus. 30 Oct 2009
• Design of proteolytically stable RI-anchoring disruptor peptidomimetics for in vivo studies of anchored type I protein kinase A-mediated signalling. 21 Oct 2009
• Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing. 19 Oct 2009
• Grafting neural precursor cells promotes functional recovery in an SCA1 mouse model. 19 Oct 2009
• Dominant role of antigen dose in CD4+Foxp3+ regulatory T cell induction and expansion. 13 Oct 2009
• A solid-state deuterium NMR and sum-frequency generation study of the side-chain dynamics of peptides adsorbed onto surfaces. 12 Oct 2009
• Intramolecular amide stacking and its competition with hydrogen bonding in a small foldamer. 12 Oct 2009
• The effect of sex peptide and calorie intake on fecundity in female Drosophila melanogaster. 12 Oct 2009
• Police find range of drugs after trawling bins used by Tour de France cyclists. 11 Oct 2009
• Fluorine substitutions in an antigenic peptide selectively modulate T-cell receptor binding in a minimally perturbing manner. 10 Oct 2009
• Involvement of interleukin-15 and interleukin-21, two gamma-chain-related cytokines, in celiac disease. 5 Oct 2009

See a longer list of these articles.

Technical information about 'Peptides'

Definition: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.

Registry Number: 0

Descriptor UI: D010455

Alternative terms: Peptides; Polypeptides;

Related Mesh Headings: Amino Acid Sequence;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D12.644;

Technical Notes: general; prefer specifics; fewer than 13 amino acids = oligopeptides; "primary structure" = PROTEIN STRUCTURE, PRIMARY see AMINO ACID SEQUENCE; peptide structure other than primary: coordinate IM with PROTEIN CONFORMATION or its specifics