Perindopril - Pharmacology
Research News and Information

Sunday, November 22, 2009

Long-term effects of perindopril on left ventricular structure and function in patients with stable coronary artery disease: a conventional and Doppler tissue echocardiographic pilot study.

29 Sep 2009 OBJECTIVES: The aim of this study was to investigate the long-term effects of perindopril on left ventricular (LV) systolic and diastolic function in patients with stable coronary artery disease who had previously undergone coronary artery bypass ... Read more...

The effects of perindopril on aortic elasticity and inflammatory markers in hypertensive patients.

29 Jun 2009 BACKGROUND: Inflammation plays an important role in hypertension and in atherosclerosis. Inflammatory changes induced even in prehypertensive subjects can lead to increased arterial stiffness. The effects of perindopril on both inflammatory and ... Read more...

Decreased muscle ACE activity enhances functional response to endurance training in rats, without change in muscle oxidative capacity or contractile phenotype.

28 Apr 2009 In the present study, we tested the hypothesis that chronic ANG I-converting enzyme (ACE) inhibition could improve the training-induced improvement in endurance exercise performance and that this could be related to enhanced skeletal muscle ... Read more...

Latest indexed articles for 'Perindopril - Pharmacology'

These are the very latest articles for this heading:

• Long-term effects of perindopril on left ventricular structure and function in patients with stable coronary artery disease: a conventional and Doppler tissue echocardiographic pilot study. 29 Sep 2009
• The effects of perindopril on aortic elasticity and inflammatory markers in hypertensive patients. 29 Jun 2009
• Decreased muscle ACE activity enhances functional response to endurance training in rats, without change in muscle oxidative capacity or contractile phenotype. 28 Apr 2009
• [Fixed combination perindopril-amlodipine (Coveram) in the treatment of hypertension and coronary heart disease] 30 Mar 2009
• ACE-inhibitor suppresses the apoptosis induced by endoplasmic reticulum stress in renal tubular in experimental diabetic rats. 17 Mar 2009
• Blood pressure response under chronic antihypertensive drug therapy: the role of aortic stiffness in the REASON (Preterax in Regression of Arterial Stiffness in a Controlled Double-Blind) study. Feb 2009
• Protective effect of perindopril on diabetic retinopathy is associated with decreased vascular endothelial growth factor-to-pigment epithelium-derived factor ratio: involvement of a mitochondria-reactive oxygen species pathway. 31 Jan 2009
• Insight into the mode of action of ACE inhibition in coronary artery disease: the ultimate 'EUROPA' story. 30 Dec 2008
• Blockade of angiotensin II attenuates VEGF-mediated blood-retinal barrier breakdown in diabetic retinopathy. 22 Dec 2008
• The rationale and design of the PERindopril GENEtic association study (PERGENE): a pharmacogenetic analysis of angiotensin-converting enzyme inhibitor therapy in patients with stable coronary artery disease. 8 Dec 2008
• Altered angiotensin-converting enzyme and its effects on the brain in a rat model of Alzheimer disease. 18 Nov 2008
• Cardiovascular outcomes and angiotensin converting enzyme inhibitors: beyond blood pressure control. Editorial to: "Secondary prevention of coronary disease with ACE inhibition--does blood pressure reduction with perindopril explain the benefits in EUROPA?" by Remme et al. 11 Nov 2008
• Molecular mechanism of limbs' postischemic revascularization improved by perindopril in diabetic rats. 3 Nov 2008
• Secondary prevention of coronary disease with ACE inhibition--does blood pressure reduction with perindopril explain the benefits in EUROPA? 16 Oct 2008
• Perindopril attenuates tubular hypoxia and inflammation in an experimental model of diabetic nephropathy in transgenic Ren-2 rats. 23 Sep 2008
• Effects of angiotensin-1 converting enzyme inhibition on oxidative stress and bradykinin receptor expression during doxorubicin-induced cardiomyopathy in rats. 30 Aug 2008
• Functional and partial morphological regression of established renal injury in the obese zucker rat by blockade of the renin-angiotensin system. 26 Aug 2008
• Effect of angiotensin-related antihypertensives on brain neurotransmitter levels in rats. 11 Aug 2008
• Selective reduction in body fat mass and plasma leptin induced by angiotensin-converting enzyme inhibition in rats. 10 Aug 2008
• Perindopril, atenolol, and amlodipine prevent aortic ultrastructural changes in rats exposed to ethanol. 29 Apr 2008

See a longer list of these articles.

Technical information about 'Perindopril'

Definition: An angiotensin-converting enzyme inhibitor. It is used in patients with hypertension and heart failure.

Chemical name: 1H-Indole-2-carboxylic acid, 1-(2-((1-(ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-

Registry Number: 82834-16-0

Descriptor UI: D020913

Alternative terms: Perindopril; Pirindopril; Perstarium; S-9490; S 9490; S9490; S 9490-3; S 9490 3; S 94903; Perindopril Erbumine; Erbumine, Perindopril;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents;

Tree Number: D03.438.473.766;

History Note: 2000; use PERINDOPRIL (NM) 1985-1999