Pharmacogenetics
Research News and Information

Saturday, November 21, 2009

Response to glucocorticoids and toxicity in childhood acute lymphoblastic leukemia: role of polymorphisms of genes involved in glucocorticoid response.

29 Nov 2009 BACKGROUND: Glucocorticoids (GCs) play a fundamental role in the treatment of pediatric acute lymphoblastic leukemia (ALL), but therapy with these agents often results in a number of severe side effects. The aim of our study was to evaluate the ... Read more...

How will GINA influence participation in pharmacogenomics research and clinical testing?

30 Oct 2009 After a 13-year battle in Congress--longer than it took to map the human genome--the Genetic Information Nondiscrimination Act (GINA) was passed into law on 21 May 2008. Before its passing, Francis Collins, then director of the National Human Genome ... Read more...

MicroRNA expression, survival, and response to interferon in liver cancer.

6 Oct 2009 BACKGROUND: Hepatocellular carcinoma is a common and aggressive cancer that occurs mainly in men. We examined microRNA expression patterns, survival, and response to interferon alfa in both men and women with the disease. METHODS: We analyzed three ... Read more...

Latest indexed articles for 'Pharmacogenetics'

These are the very latest articles for this heading:

• Response to glucocorticoids and toxicity in childhood acute lymphoblastic leukemia: role of polymorphisms of genes involved in glucocorticoid response. 29 Nov 2009
• How will GINA influence participation in pharmacogenomics research and clinical testing? 30 Oct 2009
• Nephropharmacology: drugs and the kidney. 30 Oct 2009
• The pharmacogenetics of statin therapy: when the body aches, the mind will follow. 18 Oct 2009
• An agenda for personalized medicine. 6 Oct 2009
• MicroRNA expression, survival, and response to interferon in liver cancer. 6 Oct 2009
• Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen. 5 Oct 2009
• Hepatic drug transporters, old and new: pharmacogenomics, drug response, and clinical relevance. 29 Sep 2009
• Genomics: Hepatitis C virus gets personal. 15 Sep 2009
• Opportunities and challenges for the NIH--an interview with Francis Collins. Interview by Robert Steinbrook. 14 Sep 2009
• Effects of typical and atypical antipsychotic drugs on gene expression profiles in the liver of schizophrenia subjects. 14 Sep 2009
• Pharmacogenetics in cardiovascular antithrombotic therapy. 13 Sep 2009
• [Serotonin receptor gene polymorphism and analgesic sensitivity] 30 Aug 2009
• [Gene polymorphisms in ATP (purinergic) receptors and pain sensitivity] 30 Aug 2009
• [Implication of genetic polymorphism on neuropathic pain] 30 Aug 2009
• [Side effects of opioid and gene variants] 30 Aug 2009
• [Postoperative pain management following orthognathic surgery in consideration of individual differences--is the antinociceptive effect of fentanyl related to the genotype involving nucleotide at OPRM1?] 30 Aug 2009
• [Genetic polymorphisms and human sensitivity to pain and opioids] 30 Aug 2009
• [How can we cope with wide individual variations in pain intensity and opioid requirements after surgery?] 30 Aug 2009
• [Pharmacodynamics of pain perception and polymorphism] 30 Aug 2009

See a longer list of these articles.

Technical information about 'Pharmacogenetics'

Definition: A branch of genetics which deals with the genetic variability in individual responses to drugs and drug metabolism (BIOTRANSFORMATION).

Descriptor UI: D010597

Alternative terms: Pharmacogenetics; Pharmacogenomics;

Related Mesh Headings: Drug Resistance; Toxicology;

Allowable Qualifiers: classification; economics; education; history; instrumentation; legislation & jurisprudence; manpower; methods; organization & administration; standards; trends; statistics & numerical data; ethics;

Tree Number: H01.158.273.343.750; H01.158.703.052; H02.628.479;

History Note: 70(66)

Technical Notes: SPEC or GEN; prefer specific drug & specific genetic aspect: Manual 28.22.5