Pharmacokinetics
Research News and Information

Sunday, March 21, 2010

When to conduct a renal impairment study during drug development: US Food and Drug Administration perspective.

30 Oct 2009 To optimize drug therapy for individuals, it is critical to understand how various intrinsic (e.g., age, gender, race, genetics, organ impairment) and extrinsic factors (e.g., diet, smoking, concomitantly administered drugs) affect drug exposure and ... Read more...

Drug development perspective on pharmacokinetic studies of new drugs in patients with renal impairment.

21 Sep 2009 Severe renal impairment can, through diverse mechanisms, alter the pharmacokinetics (PK) of drugs that are renally eliminated and even of some drugs that are nonrenally eliminated. Consequently, dose adjustment for new molecular entities in patients ... Read more...

A novel model and experimental analysis of hydrophilic and hydrophobic agent release from biodegradable polymers.

13 Sep 2009 Many factors affect the rate of drug release from biodegradable polymers. Here, we focus on investigating the effect of drug type on the degradation of P(DL)LGA 53/47 films and their ultimate release profiles. A freely water-soluble drug ... Read more...

Latest indexed articles for 'Pharmacokinetics'

These are the very latest articles for this heading:

• When to conduct a renal impairment study during drug development: US Food and Drug Administration perspective. 30 Oct 2009
• Use of the MDRD study equation to estimate kidney function for drug dosing. 30 Oct 2009
• Nephropharmacology: drugs and the kidney. 30 Oct 2009
• Drug development perspective on pharmacokinetic studies of new drugs in patients with renal impairment. 21 Sep 2009
• A novel model and experimental analysis of hydrophilic and hydrophobic agent release from biodegradable polymers. 13 Sep 2009
• [Anaesthesia management of the obese patient] 9 Sep 2009
• The impact of continuous renal replacement therapy on drug therapy. 31 Aug 2009
• Drug interactions in transplant patients: what everyone should know. 30 Aug 2009
• [(3)H]4-(Dimethylamino)-N-[4-(4-(2-methoxyphenyl)piperazin- 1-yl)butyl]benzamide, a selective radioligand for dopamine D(3) receptors. I. In vitro characterization. 30 Aug 2009
• Therapeutic antibody targeting of CD97 in experimental arthritis: the role of antigen expression, shedding, and internalization on the pharmacokinetics of anti-CD97 monoclonal antibody 1B2. 26 Aug 2009
• [Development of drug delivery system by utilizing absorption from liver surface and its application] 30 Jul 2009
• [Analysis of factors governing drug absorption and their improvement] 30 Jul 2009
• Stereoselective analysis of labetalol in human plasma by LC-MS/MS: application to pharmacokinetics. 30 Jul 2009
• Pharmaceutical product development technologies based on the biopharmaceutical classification system. 30 Jul 2009
• Pediatric pharmacology in the first year of life. 30 Jul 2009
• Pharmacokinetic-pharmacodynamic modeling in anesthesia, intensive care and pain medicine. 30 Jul 2009
• A Holy Grail of clinical pharmacology: prediction of drug pharmacokinetics and pharmacodynamics in the individual patient. 30 Jul 2009
• In silico prediction of volume of distribution in human using linear and nonlinear models on a 669 compound data set. 21 Jul 2009
• Drug dosing in patients with impaired renal function. 20 Jul 2009
• Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications. 20 Jul 2009

See a longer list of these articles.

Technical information about 'Pharmacokinetics'

Definition: Dynamic and kinetic mechanisms of exogenous chemical and drug ABSORPTION; BIOLOGICAL TRANSPORT; TISSUE DISTRIBUTION; BIOTRANSFORMATION; elimination; and TOXICOLOGY as a function of dosage, and rate of METABOLISM. It includes toxicokinetics, the pharmacokinetic mechanism of the toxic effects of a substance. ADME and ADMET are short-hand abbreviations for absorption, distribution, metabolism, elimination and toxicology.

Descriptor UI: D010599

Alternative terms: Pharmacokinetics; Drug Kinetics; Kinetics, Drug; Toxicokinetics;

Tree Number: G02.111.325.500; G03.787; G07.690.725;

History Note: 88

Technical Notes: general or unspecified; prefer /pharmacokin with drugs: Manual 19.7+, 19.8.53, 19.10+; DF: PHARMACOKIN