Phencyclidine - Administration & dosage
Research News and Information

Sunday, November 22, 2009

Neurochemical changes in the rat prefrontal cortex following acute phencyclidine treatment: an in vivo localized (1)H MRS study.

30 Jul 2009 Acute phencyclidine (PCP) administration mimics some aspects of schizophrenia in rats, such as behavioral alterations, increased dopaminergic activity and prefrontal cortex dysfunction. In this study, we used single-voxel (1)H-MRS to investigate ... Read more...

Antipsychotics in the early stage of development.

29 Apr 2009 PURPOSE OF REVIEW: In this article, we will summarize some of the most recent pharmacological approaches by briefly reviewing the latest research results related to different neurotransmitter receptor systems but also alternative approaches that do ... Read more...

Ultrasonic vocalisations explain unexpected effects on pre-pulse inhibition responses in rats chronically pre-treated with phencyclidine.

3 Apr 2009 Deficits in pre-pulse inhibition (PPI-indicative of psychosis in humans) can be replicated in rats using the NMDA receptor antagonist phencyclidine (PCP). Ultrasonic vocalisations (USVs) produced by rats in response to acoustic startle are ... Read more...

Latest indexed articles for 'Phencyclidine - Administration & dosage'

These are the very latest articles for this heading:

• Neurochemical changes in the rat prefrontal cortex following acute phencyclidine treatment: an in vivo localized (1)H MRS study. 30 Jul 2009
• Antipsychotics in the early stage of development. 29 Apr 2009
• Ultrasonic vocalisations explain unexpected effects on pre-pulse inhibition responses in rats chronically pre-treated with phencyclidine. 3 Apr 2009
• Evaluation of NMDA receptor models of schizophrenia: divergences in the behavioral effects of sub-chronic PCP and MK-801. 12 Feb 2009
• Acute phencyclidine administration reduces extracellular glutamate levels and the expression of synaptophysin and SNAP-25 in rat frontal cortex. 18 Dec 2008
• Effect of an NCAM mimetic peptide FGL on impairment in spatial learning and memory after neonatal phencyclidine treatment in rats. 12 Dec 2008
• Clozapine attenuates disruptions in response inhibition and task efficiency induced by repeated phencyclidine administration in the intracranial self-stimulation procedure. 7 Nov 2008
• Neonatal NMDA receptor antagonist treatments have no effects on prepulse inhibition of postnatal day 25 Sprague-Dawley rats. 5 Nov 2008
• Perinatal PCP treatment alters the developmental expression of prefrontal and hippocampal muscarinic receptors. 7 Oct 2008
• Atypical anti-schizophrenic drugs prevent changes in cortical N-methyl-D-aspartate receptors and behavior following sub-chronic phencyclidine administration in developing rat pups. 29 Sep 2008
• Increased impulsivity and disrupted attention induced by repeated phencyclidine are not attenuated by chronic quetiapine treatment. 6 Sep 2008
• Neonatal PCP is more potent than ketamine at modifying preweaning behaviors of Sprague-Dawley rats. 28 Jul 2008
• Disturbances in social interaction occur along with pathophysiological deficits following sub-chronic phencyclidine administration in the rat. 23 Jul 2008
• Drug-anaesthetic interaction in phMRI: the case of the psychotomimetic agent phencyclidine. 14 May 2008
• Repeated low dose of phencyclidine administration impairs spatial learning in mice: blockade by clozapine but not by haloperidol. 29 Jan 2008
• A preliminary investigation into the effects of antipsychotics on sub-chronic phencyclidine-induced deficits in attentional set-shifting in female rats. 13 Jan 2008
• Reversal of subchronic PCP-induced deficits in attentional set shifting in rats by sertindole and a 5-HT6 receptor antagonist: comparison among antipsychotics. 17 Dec 2007
• Differential regulation of the NMDA receptor by acute and sub-chronic phencyclidine administration in the developing rat. 4 Nov 2007
• [Drugs acting on D3 receptors in neuropsychiatric disorders: facts and prospects. Implication for schizophrenia and its treatment in the regulation of BDNF-dependence on D3 receptor expression] 30 Oct 2007
• Baseline temperature in an animal model of schizophrenia: long-term effects of perinatal phencyclidine administration. 8 Oct 2007

See a longer list of these articles.

Technical information about 'Phencyclidine'

Definition: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.

Chemical name: Piperidine, 1-(1-phenylcyclohexyl)-

Registry Number: 77-10-1

Descriptor UI: D010622

Alternative terms: Phencyclidine; Angel Dust; Dust, Angel; 1-(1-Phenylcyclohexyl)piperidine; GP-121; GP 121; GP121; Serylan; Phencyclidine Hydrochloride; Sernyl; CL-395; CL 395; CL395; Phencyclidine Hydrobromide;

Related Mesh Headings: Phencyclidine Abuse; Receptors, Phencyclidine;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Enzyme Inhibitors; Hallucinogens; Excitatory Amino Acid Antagonists;

Tree Number: D03.383.621.699;

History Note: 73(64); was see under PIPERIDINES 1969-72; was see under PIPERIDINES & ANESTHETICS 1968; was see under ANESTHETICS 1967