Phencyclidine - Pharmacology
Research News and Information

Monday, November 23, 2009

Neurochemical changes in the rat prefrontal cortex following acute phencyclidine treatment: an in vivo localized (1)H MRS study.

30 Jul 2009 Acute phencyclidine (PCP) administration mimics some aspects of schizophrenia in rats, such as behavioral alterations, increased dopaminergic activity and prefrontal cortex dysfunction. In this study, we used single-voxel (1)H-MRS to investigate ... Read more...

Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase.

30 Jul 2009 Thirty two analogues of phencyclidine were synthesised and tested as inhibitors of trypanothione reductase (TryR), a potential drug target in trypanosome and leishmania parasites. The lead compound BTCP (1, 1-(1-benzo[b]thiophen-2-yl-cyclohexyl) ... Read more...

Subchronic effects of phencyclidine on dopamine and serotonin receptors: implications for schizophrenia.

18 May 2009 Changes in representative dopamine (D(1), D(2), and D(4)) and serotonin (5-HT(1A) and 5-HT(2A)) receptors that have been implicated in the pathophysiology and treatment of schizophrenia were autoradiographically quantified after subchronic ... Read more...

Latest indexed articles for 'Phencyclidine - Pharmacology'

These are the very latest articles for this heading:

• Neurochemical changes in the rat prefrontal cortex following acute phencyclidine treatment: an in vivo localized (1)H MRS study. 30 Jul 2009
• Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase. 30 Jul 2009
• Subchronic effects of phencyclidine on dopamine and serotonin receptors: implications for schizophrenia. 18 May 2009
• Antipsychotics in the early stage of development. 29 Apr 2009
• Effects of trihexyphenydil, the structural analog of phencyclidine, on neocortical and hippocampal electrical activity in sleep-waking cycle. 30 Mar 2009
• The five choice serial reaction time task: comparison between Sprague-Dawley and Long-Evans rats on acquisition of task, and sensitivity to phencyclidine. 30 Mar 2009
• Altered mnemonic functions and resistance to N-METHYL-d-Aspartate receptor antagonism by forebrain conditional knockout of glycine transporter 1. 26 Mar 2009
• Interactions between the glycine transporter 1(GlyT1) inhibitor SSR504734 and psychoactive drugs in mouse motor behaviour. 15 Mar 2009
• GLT-1 up-regulation enhances the effect of PCP on prepulse inhibition of the startle reflex in adult rats. 7 Mar 2009
• Evaluation of NMDA receptor models of schizophrenia: divergences in the behavioral effects of sub-chronic PCP and MK-801. 12 Feb 2009
• Behavioral changes in G72/G30 transgenic mice. 30 Jan 2009
• The discriminative stimulus effects of N-methyl-D-aspartate glycine-site ligands in NMDA antagonist-trained rats. 26 Jan 2009
• Excitatory and inhibitory neurotransmission is chronically altered following perinatal NMDA receptor blockade. 13 Jan 2009
• Prefrontal GABA(B) receptor activation attenuates phencyclidine-induced impairments of prepulse inhibition: involvement of nitric oxide. 12 Jan 2009
• Mechanistic analysis of the inactivation of cytochrome P450 2B6 by phencyclidine: effects on substrate binding, electron transfer, and uncoupling. 12 Jan 2009
• The importance of nitric oxide in social dysfunction. 6 Jan 2009
• Phencyclidine affects firing activity of basolateral amygdala neurons related to social behavior in rats. 5 Jan 2009
• Synthesis and study on analgesic effects of 1-[1-(4-methylphenyl) (cyclohexyl)] 4-piperidinol and 1-[1-(4-methoxyphenyl) (cyclohexyl)] 4-piperidinol as two new phencyclidine derivatives. 30 Dec 2008
• Effect of an NCAM mimetic peptide FGL on impairment in spatial learning and memory after neonatal phencyclidine treatment in rats. 12 Dec 2008
• Probing the structure of the affinity-purified and lipid-reconstituted torpedo nicotinic acetylcholine receptor. 30 Nov 2008

See a longer list of these articles.

Technical information about 'Phencyclidine'

Definition: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.

Chemical name: Piperidine, 1-(1-phenylcyclohexyl)-

Registry Number: 77-10-1

Descriptor UI: D010622

Alternative terms: Phencyclidine; Angel Dust; Dust, Angel; 1-(1-Phenylcyclohexyl)piperidine; GP-121; GP 121; GP121; Serylan; Phencyclidine Hydrochloride; Sernyl; CL-395; CL 395; CL395; Phencyclidine Hydrobromide;

Related Mesh Headings: Phencyclidine Abuse; Receptors, Phencyclidine;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Enzyme Inhibitors; Hallucinogens; Excitatory Amino Acid Antagonists;

Tree Number: D03.383.621.699;

History Note: 73(64); was see under PIPERIDINES 1969-72; was see under PIPERIDINES & ANESTHETICS 1968; was see under ANESTHETICS 1967