Phencyclidine
Research News and Information

Monday, November 23, 2009

Prenatal phencyclidine exposure alters hippocampal cell proliferation in offspring rats.

30 Aug 2009 Multiple case reports have described pregnancy in phencyclidine hydrochloride (PCP) abusers. Characteristic clinical symptoms of PCP-exposed infants have revealed neurobehavioral or physical abnormalities. We designed this study to evaluate whether ... Read more...

Neurochemical changes in the rat prefrontal cortex following acute phencyclidine treatment: an in vivo localized (1)H MRS study.

30 Jul 2009 Acute phencyclidine (PCP) administration mimics some aspects of schizophrenia in rats, such as behavioral alterations, increased dopaminergic activity and prefrontal cortex dysfunction. In this study, we used single-voxel (1)H-MRS to investigate ... Read more...

Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase.

30 Jul 2009 Thirty two analogues of phencyclidine were synthesised and tested as inhibitors of trypanothione reductase (TryR), a potential drug target in trypanosome and leishmania parasites. The lead compound BTCP (1, 1-(1-benzo[b]thiophen-2-yl-cyclohexyl) ... Read more...

Latest indexed articles for 'Phencyclidine'

These are the very latest articles for this heading:

• Prenatal phencyclidine exposure alters hippocampal cell proliferation in offspring rats. 30 Aug 2009
• Neurochemical changes in the rat prefrontal cortex following acute phencyclidine treatment: an in vivo localized (1)H MRS study. 30 Jul 2009
• Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase. 30 Jul 2009
• Dopamine D2High receptors stimulated by phencyclidines, lysergic acid diethylamide, salvinorin A, and modafinil. 30 Jul 2009
• Subchronic effects of phencyclidine on dopamine and serotonin receptors: implications for schizophrenia. 18 May 2009
• Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent subchronic administration of donepezil: role of sigma-1 receptors. 7 May 2009
• [Ecstasy, new psychotropic drugs] 29 Apr 2009
• Antipsychotics in the early stage of development. 29 Apr 2009
• Ultrasonic vocalisations explain unexpected effects on pre-pulse inhibition responses in rats chronically pre-treated with phencyclidine. 3 Apr 2009
• [Development of animal models for schizophrenia based on clinical evidence: expectation for psychiatrists] 30 Mar 2009
• Effects of trihexyphenydil, the structural analog of phencyclidine, on neocortical and hippocampal electrical activity in sleep-waking cycle. 30 Mar 2009
• Generation and utilization of anti-drug monoclonal antibodies for screening of 36 drug users by dot-ELISA. 30 Mar 2009
• The five choice serial reaction time task: comparison between Sprague-Dawley and Long-Evans rats on acquisition of task, and sensitivity to phencyclidine. 30 Mar 2009
• Altered mnemonic functions and resistance to N-METHYL-d-Aspartate receptor antagonism by forebrain conditional knockout of glycine transporter 1. 26 Mar 2009
• Interactions between the glycine transporter 1(GlyT1) inhibitor SSR504734 and psychoactive drugs in mouse motor behaviour. 15 Mar 2009
• Activation of dopamine D1 receptors blocks phencyclidine-induced neurotoxicity by enhancing N-methyl-D-aspartate receptor-mediated synaptic strength. 8 Mar 2009
• GLT-1 up-regulation enhances the effect of PCP on prepulse inhibition of the startle reflex in adult rats. 7 Mar 2009
• D(1)-like receptor activation improves PCP-induced cognitive deficits in animal models: Implications for mechanisms of improved cognitive function in schizophrenia. 3 Mar 2009
• High specific activity tritiation of TCP and BTCP. 2 Mar 2009
• Brief exposure to methamphetamine (METH) and phencyclidine (PCP) during late development leads to long-term learning deficits in rats. 22 Feb 2009

See a longer list of these articles.

Technical information about 'Phencyclidine'

Definition: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.

Chemical name: Piperidine, 1-(1-phenylcyclohexyl)-

Registry Number: 77-10-1

Descriptor UI: D010622

Alternative terms: Phencyclidine; Angel Dust; Dust, Angel; 1-(1-Phenylcyclohexyl)piperidine; GP-121; GP 121; GP121; Serylan; Phencyclidine Hydrochloride; Sernyl; CL-395; CL 395; CL395; Phencyclidine Hydrobromide;

Related Mesh Headings: Phencyclidine Abuse; Receptors, Phencyclidine;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Enzyme Inhibitors; Hallucinogens; Excitatory Amino Acid Antagonists;

Tree Number: D03.383.621.699;

History Note: 73(64); was see under PIPERIDINES 1969-72; was see under PIPERIDINES & ANESTHETICS 1968; was see under ANESTHETICS 1967