Phosphoric Diester Hydrolases - Metabolism
Research News and Information

Monday, November 23, 2009

Structure elucidation and preliminary assessment of hydrolase activity of PqsE, the Pseudomonas quinolone signal (PQS) response protein.

Nov 2009 In bacteria, the transcription of virulence genes is usually controlled by a cell density-dependent process known as "quorum sensing" (QS). QS relies on small diffusible signaling molecules that cross the bacterial cell wall and activate target ... Read more...

An oxygen-sensing diguanylate cyclase and phosphodiesterase couple for c-di-GMP control.

18 Oct 2009 A commonly observed coupling of sensory domains to GGDEF-class diguanylate cyclases and EAL-class phosphodiesterases has long suggested that c-di-GMP synthesizing and degrading enzymes sense environmental signals. Nevertheless, relatively few signal ... Read more...

GPI glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the ER to the Golgi.

14 Oct 2009 Many eukaryotic proteins are attached to the cell surface via glycosylphosphatidylinositol (GPI) anchors. How GPI-anchored proteins (GPI-APs) are trafficked from the endoplasmic reticulum (ER) to the cell surface is poorly understood, but the GPI ... Read more...

Latest indexed articles for 'Phosphoric Diester Hydrolases - Metabolism'

These are the very latest articles for this heading:

• Structure elucidation and preliminary assessment of hydrolase activity of PqsE, the Pseudomonas quinolone signal (PQS) response protein. Nov 2009
• An oxygen-sensing diguanylate cyclase and phosphodiesterase couple for c-di-GMP control. 18 Oct 2009
• GPI glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the ER to the Golgi. 14 Oct 2009
• Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity. 10 Oct 2009
• A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage. 29 Sep 2009
• Structural and mechanistic determinants of c-di-GMP signalling. 29 Sep 2009
• The antioxidant enzyme Prdx1 controls neuronal differentiation by thiol-redox-dependent activation of GDE2. 16 Sep 2009
• Reducing the mystery of neuronal differentiation. 16 Sep 2009
• Diphosphonucleotide phosphatase/phosphodiesterase (PPD1) from yellow lupin (Lupinus luteus L.) contains an iron-manganese center. 11 Sep 2009
• An in vitro model for de- and remyelination using lysophosphatidyl choline in rodent whole brain spheroid cultures. 30 Aug 2009
• Unrepaired oxidative DNA damage induces an ATR/ATM apoptotic-like response in quiescent fission yeast. 27 Aug 2009
• Mechanism regulating proasthmatic effects of prolonged homologous beta2-adrenergic receptor desensitization in airway smooth muscle. 5 Aug 2009
• The basophil activation test in immediate-type drug allergy. 30 Jul 2009
• Interactions between cyclic nucleotide phosphodiesterase 11 catalytic site and substrates or tadalafil and role of a critical Gln-869 hydrogen bond. 27 Jul 2009
• Deterministic mathematical models of the cAMP pathway in Saccharomyces cerevisiae. 14 Jul 2009
• Predicting the distribution of spiral waves from cell properties in a developmental-path model of Dictyostelium pattern formation. 8 Jul 2009
• Suppression of PC-1/ENPP-1 expression improves insulin sensitivity in vitro and in vivo. Jul 2009
• [Significance of phosphodiesterase isoenzymes in the control of human detrusor smooth muscle function. An immunohistochemical and functional study] 29 Jun 2009
• Theophylline again? Reasons for believing. 29 Jun 2009
• Temporal changes in vascular reactivity in early diabetes mellitus in rats: role of changes in endothelial factors and in phosphodiesterase activity. 17 Jun 2009

See a longer list of these articles.

Technical information about 'Phosphoric Diester Hydrolases'

Definition: A class of enzymes that catalyze the hydrolysis of one of the two ester bonds in a phosphodiester compound. EC 3.1.4.

Registry Number: EC 3.1.4.-

Descriptor UI: D010727

Alternative terms: Phosphoric Diester Hydrolases; Hydrolases, Phosphoric Diester; Phosphodiesterases;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.277.352.640;

Online Note: use PHOSPHORIC DIESTER HYDROLASES to search PHOSPHODIESTERASES 1972-93 (as Prov 1972-73)

History Note: 94; was PHOSPHODIESTERASES 1972-93 (Prov 1972-73)

Technical Notes: /antag = PHOSPHORIC DIESTER HYDROLASE INHIBITORS (see PHOSPHODIESTERASE INHIBITORS)