Phosphorylation - Physiology
Research News and Information

Monday, November 23, 2009

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.

2 Nov 2009 Leucine-rich repeat kinase 2 (LRRK2) functions as a putative protein kinase of ezrin, radixin, and moesin (ERM) family proteins. A Parkinson's disease-related G2019S substitution in the kinase domain of LRRK2 further enhances the phosphorylation of ... Read more...

Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations.

12 Oct 2009 In Alzheimer's disease (AD), rod-like cofilin aggregates (cofilin-actin rods) and thread-like inclusions containing phosphorylated microtubule-associated protein (pMAP) tau form in the brain (neuropil threads), and the extent of their presence ... Read more...

Signal transduction responses to lysophosphatidic acid and sphingosine 1-phosphate in human prostate cancer cells.

29 Sep 2009 BACKGROUND: Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are lipid mediators that bind to G-protein-coupled receptors. In this study, signaling responses to 18:1 LPA and S1P were examined in parallel in three human prostate cancer ... Read more...

Latest indexed articles for 'Phosphorylation - Physiology'

These are the very latest articles for this heading:

• Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis. 2 Nov 2009
• Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations. 12 Oct 2009
• Signal transduction responses to lysophosphatidic acid and sphingosine 1-phosphate in human prostate cancer cells. 29 Sep 2009
• IGF-I promotes neuronal migration and positioning in the olfactory bulb and the exit of neuroblasts from the subventricular zone. 25 Aug 2009
• Fates of neurotrophins after retrograde axonal transport: phosphorylation of p75NTR is a sorting signal for delayed degradation. 24 Aug 2009
• PACS-1 mediates phosphorylation-dependent ciliary trafficking of the cyclic-nucleotide-gated channel in olfactory sensory neurons. 24 Aug 2009
• Phosphorylation of TPX2 by Plx1 enhances activation of Aurora A. 20 Aug 2009
• Function of tau protein in adult newborn neurons. 16 Aug 2009
• TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling. 15 Aug 2009
• Repression of tau hyperphosphorylation by chronic endurance exercise in aged transgenic mouse model of tauopathies. 13 Aug 2009
• alpha3beta1 integrin promotes cell survival via multiple interactions between 14-3-3 isoforms and proapoptotic proteins. 11 Aug 2009
• TrkB modulates fear learning and amygdalar synaptic plasticity by specific docking sites. 10 Aug 2009
• TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II. 8 Aug 2009
• To C or not to C: direct and indirect redox regulation of Src protein tyrosine kinase. 6 Aug 2009
• Phosphorylation dynamics during early differentiation of human embryonic stem cells. 5 Aug 2009
• Epac regulates UT-A1 to increase urea transport in inner medullary collecting ducts. 4 Aug 2009
• Simvastatin acutely reduces ischemic brain damage in the immature rat via Akt and CREB activation. 3 Aug 2009
• Chking and executing cell division to prevent genomic instability. Aug 2009
• Cytoprotective effect of polypeptide from Chlamys farreri on neuroblastoma (SH-SY5Y) cells following HO exposure involves scavenging ROS and inhibition JNK phosphorylation. Aug 2009
• A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Phosphorylation'

Definition: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.

Descriptor UI: D010766

Alternative terms: Phosphorylation; Phosphorylations;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: G02.111.087.677; G02.149.115.677; G02.149.465.700; G02.607.750.700; G03.495.790;

History Note: 91(79); was see under CHEMISTRY, ORGANIC 1979-90

Technical Notes: almost never IM; enzymatic phosphorylation: coord NIM with PHOSPHOTRANSFERASES (IM) + substrate (NIM) or specific phosphotransferase (particularly KINASES or PROTEIN KINASES) (IM); OXIDATIVE PHOSPHORYLATION & PHOTOPHOSPHORYLATION are also available