Pindolol - Pharmacology
Research News and Information

Monday, November 23, 2009

Placental and fetal hemodynamics after labetalol or pindolol in a sheep model of increased placental vascular resistance and maternal hypertension.

18 Apr 2009 We investigated the effects of labetalol and pindolol on uterine, placental, and fetal hemodynamics following norepinephrine-induced maternal hypertension in a sheep model of increased placental vascular resistance. Also, we examined fetal and ... Read more...

Heart rate variability in rats with experimental chronic heart failure and long-term exposure to beta-adrenoblockers.

30 Jan 2009 Simulation of chronic heart failure in rats led to an increase in heart rate variability and decrease in heart rate. All beta-blockers also promoted the heart rate variability augmentation in ill animals. The most potent effects on heart rate ... Read more...

WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation.

30 Jan 2009 In-vitro studies have shown that WAY 100635 is not only a potent 5-HT1A antagonist, but also has high affinity and efficacy at the dopamine D(4) receptor. Nevertheless, the behavioral effects of this compound have not been investigated. This study ... Read more...

Latest indexed articles for 'Pindolol - Pharmacology'

These are the very latest articles for this heading:

• Placental and fetal hemodynamics after labetalol or pindolol in a sheep model of increased placental vascular resistance and maternal hypertension. 18 Apr 2009
• Heart rate variability in rats with experimental chronic heart failure and long-term exposure to beta-adrenoblockers. 30 Jan 2009
• WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation. 30 Jan 2009
• Glomerular filtration rate after tramadol, parecoxib and pindolol following anaesthesia and analgesia in comparison with morphine in dogs. 30 Dec 2008
• Acute effects of combining citalopram and pindolol on regional brain serotonin synthesis in sham operated and olfactory bulbectomized rats. 25 Nov 2008
• Preservation of the positive lusitropic effect of beta-adrenoceptors stimulation in diabetic cardiomyopathy. 29 Sep 2008
• [5-HT1A/1B receptors, alpha2-adrenoceptors and the post-receptor adenylate cyclase activation in the mice brain are involved in the antidepressant-like action of agmatine] 29 Apr 2008
• Serotonin receptors contribute to the promnesic effects of P. olacoides (Marapuama). 29 Apr 2008
• Significance of the adrenergic system in the regulation of vasopressin secretion in rat neurohypophyseal tissue cultures. 24 Mar 2008
• 5-HT excites globus pallidus neurons by multiple receptor mechanisms. 5 Nov 2007
• An index of 5-HT synthesis changes during early antidepressant treatment: alpha-[11C]methyl-L-tryptophan PET study. 4 Sep 2007
• Electrophysiologic changes in ventral midbrain dopaminergic neurons resulting from (+/-) -3,4-methylenedioxymethamphetamine (MDMA-"Ecstasy"). 21 May 2007
• Antidepressant-like effects of Albizzia julibrissin in mice: involvement of the 5-HT1A receptor system. 4 Apr 2007
• Development of a multiplex non-radioactive receptor assay: the benzodiazepine receptor, the serotonin transporter and the beta-adrenergic receptor. 30 Dec 2006
• The role of 5-HT1a and 5-HT2a receptors in attention and motor control: a mechanistic study in healthy volunteers. 22 Nov 2006
• Selective verbal and spatial memory impairment after 5-HT1A and 5-HT2A receptor blockade in healthy volunteers pre-treated with an SSRI. 6 Nov 2006
• Potential involvement of a propranolol-insensitive atypical beta-adrenoceptor the vasodilator effect of cyanopindolol in the human pulmonary artery. 30 Aug 2006
• Pindolol does not augment central serotonin function increases to citalopram in humans: an auditory evoked potential investigation. 8 Aug 2006
• 5-HT-stimulated [35S]guanosine-5'-O-(3-thio)triphosphate binding as an assay for functional activation of G proteins coupled with 5-HT1B receptors in rat striatal membranes. 19 Feb 2006
• Pindolol augmentation of antidepressant response. 30 Jan 2006

See a longer list of these articles.

Technical information about 'Pindolol'

Definition: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)

Chemical name: 2-Propanol, 1-(1H-indol-4-yloxy)-3-((1-methylethyl)amino)-

Registry Number: 13523-86-9

Descriptor UI: D010869

Alternative terms: Pindolol; Prindolol; Visken; LB-46; LB 46; LB46;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Adrenergic beta-Antagonists; Antihypertensive Agents; Serotonin Antagonists; Vasodilator Agents;

Tree Number: D02.033.100.624.748; D02.033.755.624.748; D02.092.063.624.698.699;

History Note: 73